3D printing and bioprinting technologies are revolutionizing tissue engineering by enabling the fabrication of intricate, hierarchical structures that mimic native tissues. Recent advancements in high-speed bioprinting systems—such as acoustic wave-guided platforms and embedded ink writing—have dramatically improved fabrication efficiency, achieving appreciable printing speeds (e.g., exceeding 100 mm/s) without compromising micron-scale resolution. Concurrently, the development of dynamic bioinks, including shear-thinning hydrogels and enzyme-responsive materials, has introduced unprecedented control over post-printing tissue maturation and functional integration. Despite these strides, challenges persist in scaling these technologies for industrial adoption, ensuring reproducibility across laboratories, and engineering multi-material constructs that replicate the mechanical and biological gradients of natural tissues. This Research Topic seeks to address these gaps by highlighting innovations in speed-optimized bioprinting, functionally adaptive biomaterials, and standardized workflows that bridge laboratory research with industrial-scale biofabrication.
This Research Topic aims to compile cutting-edge research on the integration of high-speed bioprinting technologies and dynamic biomaterials for engineering complex tissues. We prioritize studies that advance the following areas: (1) novel bioprinting platforms capable of rapid, high-resolution fabrication of multi-scale architectures, such as vascular networks and neural interfaces; (2) bioinks with tunable viscoelastic, self-healing, or stimuli-responsive properties that enable dynamic tissue remodeling; (3) scalable manufacturing strategies, including AI-driven process optimization and quality assurance frameworks, to ensure reproducibility and industrial compatibility. By fostering interdisciplinary dialogue among engineers, materials scientists, and industry leaders, this issue will establish best practices for translating biofabrication breakthroughs into robust, large-scale solutions for tissue engineering.
The Research Topic will encompass advancements across the entire biofabrication pipeline, from technology development to industrial scalability. Topics of interest include high-speed bioprinting systems (e.g., acoustic, electrohydrodynamic, or multi-photon lithography platforms), dynamic biomaterials such as 4D-printable hydrogels and hybrid polymer-ceramic composites, and AI-enhanced design tools for patient-specific tissue constructs. Applications may focus on engineering vascularized bone scaffolds, multi-layered skin grafts, or neural interfaces with axon-guiding microarchitectures. We also welcome studies addressing scalability challenges, including standardized protocols for cross-laboratory reproducibility, real-time process monitoring systems, and quality control metrics for industrial adoption. Submissions may include original research articles, comprehensive reviews, methodological papers emphasizing reproducible workflows, and perspectives on emerging trends in biofabrication technology and materials science.
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Methods
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
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