Sensory-driven neural circuit maturation and implications for neurodevelopmental disorders

The sensory systems profoundly impact cortical development, establishing and refining neural circuits through experience-driven and activity-dependent processes. Recent research consistently identifies sensory processing disruptions as significant early markers associated with neurodevelopmental conditions, particularly autism spectrum disorder (ASD). Studies have demonstrated atypical responsiveness and abnormal wiring patterns in sensory cortical networks, suggesting that these disturbances may play a crucial role in the onset or progression of neurodevelopmental impairments. Despite these advancements, key questions remain unanswered concerning the underlying neural mechanisms by which sensory experiences shape cortical circuits, the interaction between typical sensory inputs and circuit maturation, and precisely how early sensory dysregulation contributes causally to cognitive and behavioral deficits observed in disorders such as ASD.

This Research Topic aims to investigate the neural developmental processes influenced by sensory experiences, toward clarifying the pathways through which sensory information and neural activity guide cortical organization. Additionally, it seeks to elucidate how alterations or aberrations in this sensory-dependent development can lead to or indicate the emergence of neurodevelopmental disorders. Crucial objectives include understanding the contributions of sensory-driven activity to typical maturation, the temporal dynamics of critical developmental periods, and the direct mechanistic relationships linking sensory system dysfunction to subsequent cognitive and behavioral impairments. Addressing these aims will enhance the identification of early diagnostic biomarkers and aid in designing targeted, sensory-based therapeutic interventions.

To gather further insights into sensory-driven cortical development processes and their link to neurodevelopmental conditions, we welcome articles addressing, but not limited to, the following themes:

- Neural mechanisms mediating activity-dependent formation and refinement of sensory circuits during early development

- Consequences of altered sensory experiences on the establishment and maintenance of cortical network connectivity

- Identifying critical developmental windows for sensory cortical maturation and plasticity

- Sensory abnormalities as early indicators and biomarkers for neurodevelopmental disorders, including autism

- Developmental timing and efficacy of sensory-focused therapeutic interventions in neurodevelopmental conditions

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Sensory systems, Cortical development, Neurodevelopmental conditions, Autism spectrum disorder (ASD), Sensory abnormalities

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.