Combination Cancer Therapies and Systems Immunology

In the evolving field of oncology, the development of combination cancer therapies has emerged as a promising approach to enhance treatment efficacy and address the challenge of resistance.

There is an increasing appreciation that even conventional drug therapies have substantial immunomodulatory effects, which suggests they could be harnessed in new combinations focused on their effect on the immune system, as well as combined with leading immunotherapies designed to primarily target the immune system.
By integrating multiple therapeutic modalities, these strategies aim to target cancer cells with more precision and efficiency while minimizing adverse effects. A thorough understanding of immune system interactions is crucial for the success of these therapies, and this is precisely where systems immunology contributes significantly. This interdisciplinary approach helps to map out the complex interactions between cancer and the immune system, fostering innovations in therapeutic options that can potentially revolutionize cancer treatment.

This Research Topic aims to explore the intersection of combination cancer therapies and systems immunology, shedding light on groundbreaking research and advancements in the field. The main objectives include analyzing how diverse therapeutic agents work synergistically, understanding the modulation of immune responses, and examining the efficacy of these treatments in minimizing toxicity. It seeks to address specific questions regarding the integration of advanced computational models and bioinformatics tools in predicting therapy combinations and patient outcomes, ultimately hypothesizing on the effective design of next-generation therapeutic strategies.

To gather further insights into the realm of integrating cancer therapies with systems immunology, we welcome articles addressing, but not limited to, the following themes:

• Mechanistic insights into synergistic interactions of therapeutic agents

• Emerging technologies in predicting successful therapy combinations

• Clinical applications showcasing immune modulation in various cancer types

• Case studies and trial results demonstrating therapeutic efficacy

• Future perspectives on the challenges and opportunities in designing innovative cancer treatments informed by systems immunology’s insights.

This topic accommodates original research, review articles, and opinion pieces.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Cancer therapies, Combination therapeutics

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.