Emerging Therapeutics and Insights in Disorders of Pubertal Maturation

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Background

Puberty is a complex, tightly regulated process influenced by environmental and hormonal pathways, neuroendocrine signals, and genetic factors. Disruptions in pubertal timing, such as precocious puberty and delayed puberty, can have significant implications for growth, metabolic health, psychosocial well-being, and long-term endocrine function. Although established treatments exist, emerging therapeutics offer promising new approaches to modulating pubertal regulation with greater precision and improved safety profiles.

This Research Topic aims to explore novel pharmacological agents and therapeutic strategies targeting the regulatory mechanisms of puberty . We welcome studies investigating cutting-edge treatments that influence gonadotropin-releasing hormone (GnRH) secretion, sex steroid production, and associated endocrine pathways in children and adolescents.

By gathering research on emerging therapeutics, this collection aims to advance clinical management strategies and enhance outcomes for children with disorders of pubertal maturation. We encourage submissions of original research, reviews, and clinical studies to contribute to this evolving field.

We invite submissions on topics including, but not limited to:

• Novel pharmacological agents for managing precocious puberty.

• New medical approaches to the treatment of delayed puberty.

• Advances in GnRH analogs but especially antagonists for puberty modulation.

• Genetic and molecular insights guiding targeted therapies for puberty disorders.

• Neuroendocrine regulation of pubertal onset and progression and its therapeutic implications.

• Outcomes and safety profiles of emerging puberty treatments.

• Personalized medicine approaches in Pediatric Endocrinology for disorders of pubertal maturation.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Case Report
  • Clinical Trial
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Case Report
  • Clinical Trial
  • Editorial
  • FAIR² Data
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Policy and Practice Reviews
  • Review
  • Study Protocol
  • Systematic Review
  • Technology and Code

Keywords: Precocious puberty, Delayed puberty, Pubertal timing, GnRH antagonists, Sex steroids, Personalized medicine

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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