Bioprinted Tumor-on-Chip Models for Gastrointestinal Cancers: Bridging Innovation and Translational Research

Bioprinted tumor-on-chip models are revolutionizing preclinical research by mimicking the structural, mechanical, and functional properties of human gastrointestinal tissues. By integrating 3D bioprinting with microfluidics, these platforms replicate complex in vivo-like environments, offering more accurate predictions of drug efficacy and toxicity in gastrointestinal cancers. These models are invaluable for personalized medicine, disease modeling, and biomarker discovery in the gastrointestinal tract. Recent advancements in bioinks, printing technologies, and cell sourcing have significantly enhanced their physiological relevance, making them powerful tools for translational research and pharmaceutical development in gastrointestinal oncology.

This Research Topic aims to showcase cutting-edge innovations in bioprinted tumor-on-chip models specifically designed for gastrointestinal cancers. We will explore how bioprinting techniques:
• Improve tumor functionality, replicate the unique microenvironments of gastrointestinal tumors, and enhance the accuracy of drug testing.
• Highlighting interdisciplinary approaches, to address the challenges of creating physiologically relevant models and scaling them up for industrial applications.
• Contributions demonstrating clinical relevance, regulatory advancements, and novel applications of tumor-on-chip technologies in drug discovery and precision medicine for gastrointestinal cancers are especially encouraged.

We invite original research articles, reviews, and perspectives focusing on bioprinted tumor-on-chip models for gastrointestinal cancers, with an emphasis on technological innovations, biomaterials, applications in cancer modeling, and regulatory considerations. Authors should emphasize translational potential and methodological advancements. High priority will be given to articles that show in vitro-in vivo correlations. Submissions will undergo peer review to ensure high scientific quality.

Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo), are out of scope for this section and will not be accepted as part of this Research Topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Bioprinting, Tumor-on-Chip, Tissue Engineering, Drug Screening, Disease Modeling

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.