The field of male fertility and spermatogenesis has been a subject of extensive research, with a particular focus on the impact of various factors such as alcohol consumption, aging, oxidative stress, and certain medical conditions like hypothyroidism and diabetes. Recent studies have highlighted the detrimental effects of these factors on sperm production and quality, often leading to infertility. Chronic alcohol consumption, for instance, has been linked to decreased libido and infertility, with studies showing increased protein and gene expression of P21 and decreased expression of cyclin D1 in testicular tissue. Aging, on the other hand, has been associated with increased inflammation, oxidation, and apoptosis in testes. Furthermore, conditions like hypothyroidism and diabetes have been found to compromise testicular redox status and disrupt the process of cell division in the testes, respectively. Despite these findings, there is a need for a better understanding of the underlying mechanisms and potential therapeutic interventions.
This Research Topic aims to delve deeper into the impact of various factors on male fertility and spermatogenesis, with a particular focus on the molecular and cellular mechanisms involved. The goal is to elucidate the role of different proteins and genes in the process of spermatogenesis and how their expression is affected by factors such as alcohol consumption, aging, oxidative stress, and certain medical conditions. Additionally, the topic aims to explore potential therapeutic interventions, including the use of natural compounds with antioxidant and anti-inflammatory properties, and their efficacy in improving sperm production and quality.
To gather further insights into the complex interplay between various factors and spermatogenesis and to prevent male infertility, we welcome articles addressing, but not limited to, the following themes: - The impact of chronic alcohol consumption on spermatogenesis and the underlying molecular mechanisms. - The role of aging in testicular inflammation, oxidation, and apoptosis, and potential therapeutic interventions. - The effects of oxidative stress on sperm production and quality, and the potential role of antioxidants in mitigating these effects. - The impact of medical conditions like hypothyroidism and diabetes on testicular redox status and spermatogenesis. - The potential therapeutic role of natural compounds with antioxidant and anti-inflammatory properties in improving spermatogenesis and male fertility.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Policy and Practice Reviews
Review
Study Protocol
Systematic Review
Technology and Code
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
