Liver injury remains a critical global health issue as it can lead to severe complications such as fibrosis, cirrhosis, and hepatocellular carcinoma. Various pathogens—most notably hepatitis viruses (such as HBV and HCV), bacteria, and parasites—can cause liver damage through complex mechanisms including immune responses, oxidative stress, and inflammatory pathways. The liver’s essential functions in metabolism, detoxification, and immune regulation make it particularly susceptible to infection-induced damage. Recent advancements in molecular biology and immunology have unveiled the complex interactions between pathogens and host defenses, highlighting pathways such as Toll-like receptor signaling, cytokine storms, and autophagy. These interactions contribute to liver injury by driving inflammation, cell death, and tissue remodeling. Despite these advancements, the detailed mechanisms of infection-related liver injury, especially in the context of co-infections, drug-induced liver injury, and the gut-liver axis, remain partially elucidated. This Research Topic seeks to explore the molecular and cellular mechanisms of liver damage, aiming to translate these findings into improved clinical outcomes.
Liver injury remains a critical global health issue as it can lead to severe complications such as fibrosis, cirrhosis, and hepatocellular carcinoma. Various pathogens—most notably hepatitis viruses (such as HBV and HCV), bacteria, and parasites—can cause liver damage through complex mechanisms including immune responses, oxidative stress, and inflammatory pathways. The liver’s essential functions in metabolism, detoxification, and immune regulation make it particularly susceptible to infection-induced damage. Recent advancements in molecular biology and immunology have unveiled the complex interactions between pathogens and host defenses, highlighting pathways such as Toll-like receptor signaling, cytokine storms, and autophagy. These interactions contribute to liver injury by driving inflammation, cell death, and tissue remodeling. Despite these advancements, the detailed mechanisms of infection-related liver injury, especially in the context of co-infections, drug-induced liver injury, and the gut-liver axis, remain partially elucidated. This Research Topic seeks to explore the molecular and cellular mechanisms of liver damage, aiming to translate these findings into improved clinical outcomes.
This Research Topic invites contributions that explore various aspects of infection-induced liver injury from molecular mechanisms to clinical applications. We encourage submissions on emerging research areas that can transform current understanding and treatment approaches, advancing the field towards holistic disease management strategies. o Investigation of the molecular mechanisms by which pathogens cause liver injury. o Analysis of immune responses and pathogen-host interactions that contribute to liver damage. o Exploration of drug-induced liver injury in the context of infections. o Evaluation of innovative therapeutic approaches for managing liver injury. o Development of novel diagnostic and treatment strategies for infection-related liver diseases.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
