Soft tissue repair remains a critical challenge in regenerative medicine, particularly in cases of severe injuries, chronic wounds, and peripheral nerve defects. Conventional therapies—such as autografts and synthetic scaffolds—often fail to recapitulate the complex microenvironment required for functional regeneration, leading to suboptimal outcomes such as fibrosis, inadequate vascularization, or delayed healing. These limitations underscore the urgent need for nanobiotechnology-driven innovations that operate at molecular and cellular scales to enhance repair mechanisms.
Recent advancements in nanoscale biomaterials have revolutionized tissue engineering by enabling precise control over scaffold architecture, mechanical properties, and bioactive cue presentation. For instance, nanostructured hydrogels and electrospun nanofibers that mimic the extracellular matrix (ECM) topography have demonstrated enhanced cell adhesion, proliferation, and lineage specification in stem cells, including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs). Such nano-biointerfaces can be functionalized with growth factors, peptides, or nucleic acids to spatiotemporally regulate stem cell fate, promoting angiogenesis, neurogenesis, or immune modulation—key processes in soft tissue regeneration.
Nanomedicine delivery systems further augment tissue repair by enabling targeted and sustained release of therapeutic agents. Smart nanoparticles (e.g., liposomes, polymeric micelles, and dendrimers) can encapsulate small molecules, nucleic acids, or proteins, protecting them from degradation while facilitating site-specific delivery to injured tissues. Additionally, stimuli-responsive nanocarriers—activated by pH, temperature, or enzymatic activity—offer spatiotemporal control over drug release, aligning with the dynamic needs of regenerating tissues.
We welcome submissions addressing, but not limited to, the following themes: 1. Advanced nanostructured scaffolds for soft tissue repair 2. Nanotechnology-enhanced stem cell therapies 3. Precision nanomedicine delivery systems 4. Intelligent stimuli-responsive nanosystems 5. Nano-diagnostics and monitoring technologies 6. Microphysiological systems for nanomedicine evaluation
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