Immune Landscape in the Transition from Inflammation to Tumorigenesis

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 8 September 2025 | Manuscript Submission Deadline 27 December 2025

  2. This Research Topic is still accepting articles.

Background

Inflammation and tumorigenesis are intricately connected processes with significant overlap in their underlying mechanisms. Chronic inflammation is now recognized as a key driver in the development of various cancers, including colorectal cancer, hepatocellular carcinoma, and gastric cancer. The immune system, which is central to both inflammation and tumor development, plays a dual role in this transition. On one hand, it acts as a guardian against cancer initiation by detecting and eliminating aberrant cells through immune surveillance. On the other hand, persistent inflammation can lead to an immunosuppressive microenvironment that fosters tumor growth, progression, and metastasis. The immune microenvironment, comprising immune cells, cytokines, chemokines, and other signaling molecules, is a critical determinant in the transition from inflammation to tumorigenesis. Understanding the dynamic changes within this microenvironment and how they influence the inflammatory and tumorigenic processes is essential for developing novel therapeutic strategies to prevent and treat cancer.



This research topic aims to comprehensively characterize the immune microenvironment in inflammation and tumorigenesis by identifying and quantifying immune cell populations such as T cells, B cells, macrophages, dendritic cells, and neutrophils in inflamed tissues and tumor microenvironments, and investigating their phenotypic and functional changes during the transition from inflammation to tumorigenesis. Elucidate the molecular mechanisms of immune regulation in this transformation, focusing on signaling pathways such as NF-κB, JAK-STAT, and MAPK, as well as the roles of cytokines, chemokines, and other soluble factors in immune cell recruitment, activation, and polarization. In addition, it is possible to study the expression and function of immune checkpoints, including molecules such as PD-1, PD-L1, and CTLA-4, and how chronic inflammation affects their expression and activity, thereby promoting immune evasion and tumor progression. Through an interdisciplinary approach, this research topic will explore the immune landscape of inflammation and tumors based on the latest scientific discoveries, aiming to contribute to more effective and personalized prevention, diagnosis and treatment of inflammation and cancer.



This Research Topic covers a wide array of relevant aspects, including:

1. Immune Cell Dynamics: The recruitment, activation, and polarization of immune cells in inflamed and tumor tissues.

2. Molecular Signaling Pathways: The role of signaling pathways in immune cell modulation and tumor development.

3. Immune Checkpoint Regulation: The expression and function of immune checkpoints in chronic inflammation and cancer.

4. Clinical and Translational Studies: The application of immunomodulatory therapies in clinical settings and their efficacy in preventing and treating inflammation-associated cancers.

5. Omics Approaches: The use of genomics, proteomics, metabolomics, and bioinformatics to dissect the complex interactions within the immune microenvironment.

6. Machine Learning and Artificial Intelligence: Using machine learning and artificial intelligence to decipher the complex immune components and dynamic evolution within inflammatory and tumor tissues, providing new insights into disease mechanisms and potential treatment strategies.

7. Single-cell Sequencing and Spatial Omics: Using single-cell technology combined with spatial omics to profile the evolution of immune features in inflammation and cancer.

8. Animal Models and In Vitro Systems: The development and utilization of relevant animal models and in vitro systems to study the inflammation-tumor transition.

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This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

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Keywords: immune, inflammation, tumor

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