Autologous Platelet-Based Therapies for Tissue Regeneration: Advances and Future Directions

Regenerative medicine is an evolving field that focuses on harnessing the body’s intrinsic ability to repair and restore damaged tissues. Autologous platelet concentrates, including Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), have emerged as promising biological tools in tissue regeneration and repair. Autologous platelet concentrates are derived from the patient’s own blood, containing a concentrated mix of growth factors, cytokines, and bioactive proteins that play a crucial role in cellular proliferation, differentiation, and matrix remodeling. Importantly, their individualized preparation aligns with the principles of personalized therapeutics and precision medicine, allowing treatment protocols to be tailored to the biological profile and clinical needs of each patient.

Despite significant advancements in regenerative medicine, there remains a need for personalized, safe, and cost-effective approaches for tissue repair. Autologous platelet concentrates offer a viable alternative to synthetic and allogeneic grafts, promoting natural healing while minimizing immunogenic responses. This research proposal aims to explore the mechanistic pathways through which autologous platelet concentrates mediate tissue regeneration, their therapeutic applications, and the optimization of protocols to enhance clinical outcomes.

This Research Topic welcomes submissions on:

- understanding the mechanisms of regeneration and repair: investigate the biological role of autologous platelet concentrates in tissue healing through cellular signaling and extracellular matrix modulation.
- analyzing the release kinetics of growth factors (e.g., PDGF, VEGF, TGF-β, IGF-1) from different platelet concentrate formulations.
- clinical applications of autologous platelet concentrates in regenerative medicine
- optimization and standardization of autologous platelet concentrates preparation techniques
- comparing different preparation methods (single vs. double spin, leukocyte-rich vs. leukocyte-poor PRP) and their impact on therapeutic efficacy.
- explore combination therapies involving autologous platelet concentrates and biomaterials for enhanced tissue integration.

We will welcome the following article types:

· Original Research
· Review Articles (systematic reviews and narrative reviews)
· Mini Reviews
· Hypothesis and Theory papers
· Methods papers

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Autologous Platelet Concentrates, Regenerative Medicine, Tissue Repair, Growth Factors, Platelet-Rich Plasma, Platelet-Rich Fibrin, Integrative Pharmacology, Biomaterials

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.