Artificial Intelligence and the Future of Biosecurity

The rapid advancements in artificial intelligence (AI) are reshaping scientific research, especially in synthetic biology and biosecurity. Breakthroughs in AI, such as language models exemplified by ChatGPT, are significantly lowering the barriers to understanding and applying advanced biological concepts. Additionally, cloud laboratories, offering biomolecule synthesis as a service with limited human overseeing and interventions, and publicly available pathogen sequences have democratized research capabilities, enabling molecular and pathogen design with minimal physical resources and expertise.

AI offers transformative potential for biosecurity. It can accelerate the development and design of vaccines, diagnostics, and therapies, model disease outbreaks, and optimize the allocation of resources during crises. Predictive AI models can identify biosecurity threats early, strengthening resilience against pandemics and bioterrorism. However, this same accessibility and biodesign capabilities can also be exploited. AI-driven models combined with cloud labs and pathogen databases reduce the technical threshold needed to design and synthesize harmful existing or novel biological agents, increasing risks and impact of misuse by individuals or groups with malicious intent.

The dual-edged nature of AI in biosecurity underscores the need for responsible innovation. This special issue explores strategies to ensure AI is designed and deployed responsibly to mitigate risks while maximizing its benefits. It highlights regulatory frameworks, technical safeguards, and ethical considerations required to guide this rapidly evolving field. By bringing together studies and expert opinions, this issue aims to provide actionable insights into how AI can enhance global biosecurity. It also calls attention to the urgent need for international cooperation and robust governance to address the challenges AI poses in democratizing access to powerful biological tools. Only by striking a balance between innovation and risk management can AI’s promise be fully realized without compromising safety.

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Artificial Intelligence, AI, Synthetic Biology, Biosecurity, Cloud Laboratories, Pathogen Design, Predictive Models, Regulatory Frameworks, Responsible Innovation

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