Endothelial Dysfunction in Metabolic Disorders: Mechanisms, Biomarkers, and Emerging Therapeutics

Endothelial dysfunction is increasingly recognized as a critical factor in the progression of metabolic disorders such as diabetes, obesity, and dyslipidemia. This condition is characterized by a reduction in nitric oxide availability, elevated oxidative stress, and increased vascular permeability, which together contribute to vascular injury and systemic inflammation. These alterations not only enhance the risk of cardiovascular and neurovascular diseases but also exacerbate the underlying metabolic disorder, creating a vicious cycle of worsening health outcomes.

This Research Topic aims to delve deeper into the cellular and molecular mechanisms contributing to endothelial dysfunction within the context of metabolic disorders. It seeks to identify new biomarkers that can aid in the early detection and evaluation of disease progression, and to spotlight innovative therapeutic approaches that could potentially reverse or mitigate these effects.

To expand the boundaries of our current understanding, we encourage contributions that cover a broad range of areas related to endothelial function in metabolic diseases. We welcome articles addressing, but not limited to, the following themes:

• Endothelial signaling pathways and their role in metabolic dysfunction
• The impact of inflammatory mediators on endothelial health
• Epigenetic factors influencing endothelial cell behavior
• Novel biomarkers for early detection of endothelial dysfunction
• Efficacy of stem cell-based therapies and pharmacological interventions in restoring endothelial function

By integrating findings from original research, reviews, and clinical studies, this Research Topic will provide a comprehensive overview of the state-of-the-art in endothelial dysfunction research and its implications for therapeutic innovation.