Skin Stem Cells and the Tumor Microenvironment: Niche Regulation in Health and Cancer

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 5 January 2026

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Background

This Research Topic explores the crucial role of stem cell–niche interactions in skin regeneration, homeostasis, and cancer. Skin stem cells, and particularly those located in the hair follicle and epidermis, depend on dynamic signaling with their local environment, including mesenchymal, immune, endothelial, melanocyte, and adipocyte populations. These interactions are key for maintaining tissue integrity and mounting responses to injury.



Disruptions in these pathways, whether from genetic mutations, environmental challenges, or aging, can lead to shifts from normal tissue repair toward tumor initiation and malignant progression. In this collection of articles we aim to highlight research that examines the molecular, cellular, and microenvironmental mechanisms governing this balance. We have a special interest in how alterations in niche signaling contribute to various forms of skin cancer and the potential for interventions that restore healthy stem cell function. By advancing our understanding of these mechanisms, this collection seeks to inform new therapeutic strategies for skin regeneration and cancer prevention.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Data Report
  • Editorial
  • FAIR² Data
  • FAIR² DATA Direct Submission
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Data Report
  • Editorial
  • FAIR² Data
  • FAIR² DATA Direct Submission
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Technology and Code

Keywords: Skin stem cells, stem cell niche, hair follicle, epidermis, tumor microenvironment, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, signaling pathways, Wnt, Shh, FGF, TGF-β, aging, inflammation, regenerative medicine, cancer stem cel

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