Virus-Induced Mechanisms and Therapeutic Vulnerabilities in Nasopharyngeal and Hepatocellular Carcinoma

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 14 October 2025 | Manuscript Submission Deadline 1 February 2026

  2. This Research Topic is still accepting articles.

Background

Nasopharyngeal carcinoma (NPC) and hepatocellular carcinoma (HCC) hold strong etiological associations with viral infections such as Epstein-Barr virus (EBV) and hepatitis B or C viruses (HBV/HCV), respectively. Viral oncogenesis in these malignancies involves complex interactions between viral factors and host cellular machinery, profoundly reshaping tumor behaviors and the tumor ecosystem.

These virus-induced alterations not only drive malignant transformation and progression but also critically modulate host immune responses, promoting immune evasion and therapeutic resistance.

Emerging evidence highlights virus-driven mechanisms including immunosuppression, metabolic reprogramming, chronic inflammation, and genetic/epigenetic alterations. These viral processes collectively create therapeutic vulnerabilities.

While recent advances in immunotherapy, targeted therapies, and combination regimens have shown promising clinical outcomes, many virus-associated tumors still exhibit unique treatment resistance, underscoring the need to comprehensively decipher virus-host interactions.

Thus, this Research Topic aims to consolidate cutting-edge studies investigating the virus-induced mechanisms underlying immune dysregulation, oncogenic signaling, and therapeutic resistance in NPC and HCC, to identify novel therapeutic vulnerabilities and inform strategies to improve treatment efficacy and patient prognosis.

This Research Topic aims to investigate virus-induced mechanisms that drive tumorigenesis, immune evasion, and therapeutic resistance in NPC and HCC. We particularly focus on the complex molecular interplay involving viral factors, tumor cells, immune cells, stromal components, and the extracellular matrix (ECM).

The primary objective is to deepen our understanding of how virus-mediated signaling pathways reshape anti-tumor immune responses and thereby influence clinical outcomes. Specifically, we seek to address the following critical questions:

1. What viral and host-derived mechanisms contribute to immune suppression, tumor progression, and therapeutic resistance in NPC and HCC?
2. How can we leverage virus-associated biomarkers or molecular signatures to stratify patients, predict therapeutic responses, and facilitate personalized therapeutic approaches?
3. What therapeutic vulnerabilities arise from virus-host interactions, and how can these be targeted to enhance the efficacy of existing and emerging treatment modalities, including immunotherapy, targeted therapy, and combination approaches?

By integrating state-of-the-art research, this Research Topic aims to elucidate virus-specific oncogenic and immunosuppressive pathways in NPC and HCC, promoting innovative therapeutic strategies and improving patient outcomes in virus-driven cancers.

We welcome submissions that investigate the diverse and evolving landscape of virus-induced mechanisms underlying tumorigenesis, immune modulation, and therapeutic resistance in NPC and HCC.
Authors are encouraged to submit original research articles, resource articles, comprehensive reviews, and perspectives addressing, but not limited to, the following themes:

• Virus-host interactions: Studies examining molecular and cellular interactions between EBV, HBV or HCV, and host immune or tumor cells, highlighting pathways critical for viral oncogenesis and immune evasion.
• Immune modulation in the virus-associated tumor ecosystem: Investigations into the roles of immune and stromal cell subsets, and ECM components modulated by viral infection in NPC and HCC.
• Virus-driven metabolic reprogramming: Research elucidating how viral infections alter cellular metabolism and subsequently impact immune responses and therapeutic responsiveness.
• Biomarkers for patient stratification and precision medicine: Studies identifying viral or host-derived biomarkers, molecular signatures, and immune profiles that can predict therapeutic responses.
• Therapeutic vulnerabilities and targets: Identification of novel therapeutic targets arising from virus-induced pathways, and preclinical or clinical evaluation of treatment strategies specifically targeting virus-host interactions.
• Omics-driven characterization: Integrated omics analyses that elucidate viral and molecular landscapes, particularly in the context of immunotherapy and targeted therapies in virus-associated NPC and HCC.
• Preclinical and clinical evaluations: Translational studies and clinical trials assessing novel therapies designed to exploit vulnerabilities resulting from virus-host interplay.
By bringing together innovative research across these thematic areas, this Research Topic aims to advance our understanding of virus-driven oncogenic mechanisms and therapeutic vulnerabilities, ultimately facilitating improved clinical outcomes for patients with NPC and HCC.

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Keywords: Immunosuppression, Intratumoral Bacteria, Tumor Ecosystem, Omics-driven Analysis, Nasopharyngeal carcinoma, hepatocellular carcinoma, virus-induced mechanisms, HCC, NPC, EBV, Epstein-Barr

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