Organosulfur compounds are increasingly recognized for their significant contributions to pharmacology, largely due to their significant bioactivities and availability in natural sources like cruciferous vegetables, onions, garlic, and sulfur-containing amino acids. Widely distributed in nature and synthetically accessible from sulfur-containing precursors, these compounds have demonstrated numerous pharmacological activities including antioxidant, anticancer, and antimicrobial effects. Additionally, they offer neuroprotective benefits in combating neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Despite their established therapeutic roles, further exploration is needed to fully elucidate their underlying mechanisms and expand their applications in drug development.
This Research Topic aims to delve into the latest advancements concerning the pharmacological activities of organosulfur compounds, their mechanisms of action, and therapeutic potential across a broad spectrum of diseases. The primary goal is to improve our understanding of these compounds' roles in oxidative stress, inflammation, and neurodegenerative diseases, and to investigate their potential in addressing microbial infections and cancer. Moreover, there is a focus on the development of organosulfur-based therapeutics through innovations in drug design, synthesis, and delivery.
To gather further insights into the pharmacological roles and therapeutic potential of organosulfur compounds, we welcome articles addressing, but not limited to, the following themes:
o Mechanisms of action underlying the pharmacological activities of organosulfur compounds.
o Therapeutic potential in addressing diseases related to oxidative stress, inflammation, and neurodegeneration.
o Cardiovascular and neuroprotective actions of organosulfur compounds.
o Innovations in the design, synthesis, and delivery of organosulfur-based therapies.
o Safety and efficacy assessment through clinical and preclinical studies.
This initiative invites contributions from researchers and experts in pharmacology, medicinal chemistry, and related disciplines, with the scope to highlight the therapeutic promise of organosulfur compounds and their potential in future medical and pharmaceutical advancements.
Additionally, we welcome various types of articles, including original research, reviews, and clinical studies, as part of this comprehensive exploration into the field of organosulfur pharmacology.
For manuscripts that focus on natural compounds, please utilize the ConPhyMP tool and ensure compliance with the standards outlined in the ConPhyMP statement (Front. Pharmacol. 13:953205). Additionally, compliance with the Four Pillars of Best Practice in Ethnopharmacology is mandatory. You can freely download the full version here. A comprehensive description of the studied material, including its identified source, extraction and processing methods, and clear composition, is essential.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Data Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Data Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Review
Systematic Review
Technology and Code
Keywords: Organosulfur, Pharmacology, Antioxidant, Anticancer, Neuroprotection, Inflammation, Drug Development, Synthesis, Mechanisms of Action, Therapeutics
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
