Advances in Regenerative Medicine for Pediatric Diseases

This Research Topic aims to highlight cutting-edge developments in basic and translational research within the field of regenerative medicine, with a focus on addressing pediatric diseases. Regenerative medicine holds immense potential to revolutionize the treatment of congenital and acquired conditions in children by harnessing stem cells, tissue engineering, gene therapy, and other innovative approaches. We seek to compile high-quality contributions that advance our understanding of regenerative mechanisms, refine therapeutic strategies, and bridge the gap between preclinical research and clinical applications.

We welcome original research articles, comprehensive reviews, methodological advances, and thought-provoking perspectives that explore the following subtopics (but are not limited to):

1. Stem cell-based regenerative medicine for pediatric diseases: Investigations into pluripotent stem cells, mesenchymal stem cells, or other progenitor cells for tissue repair, disease modeling, and cell therapy.

2. Molecular and cellular mechanisms underlying regenerative therapies: Studies elucidating signaling pathways, epigenetic regulation, and cellular interactions that drive tissue regeneration in pediatric conditions.

3. Innovative technologies and strategies in pediatric regenerative medicine:

• AI and machine learning-assisted approaches for optimizing regenerative protocols, predictive modeling, or personalized treatment design.

• Biomaterials, 3D bioprinting, and organoid technologies tailored for pediatric applications.

• Gene editing (e.g., CRISPR-Cas9) and gene therapy for correcting genetic defects in childhood disorders.

4. Preclinical and clinical translational research: Efficacy and safety studies of regenerative therapies, including animal models and early-phase clinical trials.

5. Ethical and regulatory considerations: Discussions on the challenges and opportunities in bringing regenerative therapies to pediatric populations.

By fostering interdisciplinary collaboration, this Research Topic will contribute to accelerating breakthroughs in regenerative medicine, ultimately improving outcomes for children with debilitating or life-threatening diseases.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: regenerative medicine, pediatric diseases, pediatric regenerative medicine, stem cell therapy, gene therapy, pediatric stem cell research, tissue engineering children, translational research in pediatric tissue engineering, pediatric regenerative therapies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.