Improving Efficacy and Expanding the Reach of T-Cell Therapeutics for Solid Tumors: An End-to-End Perspective

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ORIGINAL RESEARCH

Published on 01 Jul 2026

Engineering a juxtamembrane-targeting CAR T-cell against mesothelin: a novel binder resilient to shed antigen for enhanced efficacy against ovarian and pancreatic cancer

John Scholler
Ai Song
Mansi Deshmukh
Decheng Song
Khatuna Gabunia
Mei Ji
Shimin Liu
Ting-Jia Fan
Gayathri Gulendran
1 more
Don L. Siegel

doi 10.3389/fimmu.2026.1805950

2,134 views

REVIEW

Published on 17 Jun 2026

Fusion protein-mediated costimulation in engineered T cells: from intrinsic signaling to tumor microenvironment rewiring

Ryma Toumi
Simonne J. Guenette
Shannon K. Oda

doi 10.3389/fimmu.2026.1819470

1,934 views

ORIGINAL RESEARCH

Published on 11 Jun 2026

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

Maria Ormhøj
Kamilla Kjærgaard Munk
Siri Tvingsholm
Keerthana Ramanathan
Amalie Kai Bentzen
Georgios Kladis
Gitte Nygaard Aasbjerg
Grigorii Nos
Tripti Tamhane
5 more
Sine Reker Hadrup

doi 10.3389/fimmu.2026.1804678

1,025 views

REVIEW

Published on 29 May 2026

CRISPR-screen informed engineered T cell therapies

Karrie Wong
Conor Calnan
Micah J. Benson

doi 10.3389/fimmu.2026.1839064

1,653 views

REVIEW

Published on 26 May 2026

Beyond the chimeric antigen receptor T cells and bispecific antibody duopoly: ex vivo armed T cells for solid tumors

Jeong A Park
Nai-Kong V. Cheung

doi 10.3389/fimmu.2026.1822523

1,495 views

MINI REVIEW

Published on 20 May 2026

Designing universal T cell therapies: strategies to evade natural killer cells

Omar Bushara
Gerald P. Linette
Beatriz M. Carreno

doi 10.3389/fimmu.2026.1826738

1,918 views

ORIGINAL RESEARCH

Published on 15 May 2026

Clinical-scale 10-day TCR-T cell manufacturing using IL-2/7/15 and TGF-β promotes early memory and tissue-resident-like phenotypes and robust antitumor activity in vitro

Yi-Ping Shih
Stephan Drokin
Olivia Burke
Huayu Huang
Amy Leung
Marco Bravo-Manriquez
Myungkyu Jang
Marina S. Syrkina
Laura Julian
1 more
Eric Tran

doi 10.3389/fimmu.2026.1847411

3,014 views

REVIEW

Published on 14 May 2026

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy

Sarah McPhedran
Tian Zhao
Julian J. Lum

doi 10.3389/fimmu.2026.1807087

1,914 views

REVIEW

Published on 07 May 2026

Targeting solid tumors with TCR-T cells: mechanisms, progress, and challenges

Wenfang Hu
Zhongyu Zhang
Mengyao Pan
Weiye Wang
Zibing Wang

doi 10.3389/fonc.2026.1810903

2,513 views

ORIGINAL RESEARCH

Published on 16 Apr 2026

Tumor reactivity assessment using clonal expression reveals tumor reactive CD8+ T cell heterogeneity across solid tumors

David Monteiro
Jack Denebeim
Anne E. Dodson
Ashish Yeri
Mitali Ghose
Meghan Travers
Sophie Capobianco
Conor Calnan
Gustavo J. Martinez
3 more
Dipen Sangurdekar

doi 10.3389/fimmu.2026.1815974

2,372 views

ORIGINAL RESEARCH

Published on 05 Jan 2026

Comprehensive self-antigen screening to assess cross-reactivity in promiscuous T-cell receptors

Govinda Sharma
Fei Teng
James Round
Sophie A. Sneddon
Sarania Sivasothy
Scott D. Brown
Robert A. Holt

doi 10.3389/fimmu.2025.1719827

2,080 views

BRIEF RESEARCH REPORT

Accepted on 17 Aug 2026

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells

Pieter Leonard Lindenbergh
Vinagolu K. Rajasekhar
Irina Linkov
Jorge Mansilla-Soto
Sophie A. Hanina
Michel Sadelain

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Cancer Immunity and Immunotherapy

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Frontiers in Oncology
- Cancer Immunity and Immunotherapy
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Articles

Engineering a juxtamembrane-targeting CAR T-cell against mesothelin: a novel binder resilient to shed antigen for enhanced efficacy against ovarian and pancreatic cancer

Fusion protein-mediated costimulation in engineered T cells: from intrinsic signaling to tumor microenvironment rewiring

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

CRISPR-screen informed engineered T cell therapies

Beyond the chimeric antigen receptor T cells and bispecific antibody duopoly: ex vivo armed T cells for solid tumors

Designing universal T cell therapies: strategies to evade natural killer cells

Clinical-scale 10-day TCR-T cell manufacturing using IL-2/7/15 and TGF-β promotes early memory and tissue-resident-like phenotypes and robust antitumor activity in vitro

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy

Targeting solid tumors with TCR-T cells: mechanisms, progress, and challenges

Tumor reactivity assessment using clonal expression reveals tumor reactive CD8+ T cell heterogeneity across solid tumors

Comprehensive self-antigen screening to assess cross-reactivity in promiscuous T-cell receptors

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells

Frontiers in Immunology

Cancer Immunity and Immunotherapy

Other participating journals

Frontiers in Oncology

Cancer Immunity and Immunotherapy