Biomechanical Evaluation of Bone Structural Integrity: Experimental, Computational, and Clinical Perspectives

Bone biomechanics is pivotal to the health and function of the musculoskeletal system, impacting both routine physiological processes and clinical interventions. In recent years, the field has witnessed significant advancements through the development of experimental and computational approaches to analyze bone structures. These methodologies span from molecular and cellular levels to entire bone systems. Despite this progress, the challenge remains to seamlessly integrate laboratory findings and computational predictions into practical clinical solutions. Techniques such as digital image correlation, micro-computed tomography-based analyses, and sophisticated multiscale models have advanced our understanding, yet the field continues to search for effective methods to translate these insights into clinical practice.

This Research Topic aims to fulfill the pressing need for a deeper understanding of bone mechanical behavior across various scales and scenarios. The objective is to explore and validate experimental techniques and computational models that hold promise for clinical application, enhancing disease diagnosis, treatment planning, and therapeutic procedures. By bridging the gap between experimental and clinical domains, this Research Topic seeks to illuminate how biomechanical discoveries can be leveraged to improve clinical practices, with emphasis on metabolic bone diseases, fracture healing, and implant optimization.
To gather further insights into this multidisciplinary exploration of bone biomechanics, we welcome articles addressing, but not limited to, the following themes:

- Experimental Biomechanics: Advanced imaging techniques, in situ testing, bone-implant interaction studies
- Computational Modeling: Techniques in finite element analysis, multiscale simulations, and machine learning applications
- Clinical Translation: Developments in diagnostic tools, treatment planning, and biomechanical risk assessment
- Bone Remodeling and Fracture Healing: Mechanobiology research, predictive modeling, and strategies to optimize healing processes
- Emerging Technologies: Integration of hybrid techniques, artificial intelligence, and novel sensor technologies for monitoring bone health

We invite submissions that drive the discussion forward, showcasing current advancements while identifying future directions to enhance our understanding and application of bone biomechanics within clinical settings. Article types include: original research and systematic reviews.