Inflammation, Healing, and Innovation: Advances in Regenerative Therapies for Enhanced Wound Recovery

In recent years, there has been a rapid increase in the use of regenerative medicine, particularly in the fields of surgery and traumatology. The body's response to inflammation has been an ever evolving area of research over the past decades, as it is intrinsically linked to wound recovery. While acute inflammatory responses are essential for healing, chronic or dysregulated inflammation impairs regeneration and contributes to tissue fibrosis, scarring, and functional decline. Recent advances in cell-based therapies and bioengineered micrografts have opened new avenues to modulate inflammation and enhance tissue regeneration. This research area holds critical importance in reconstructive and plastic surgery as well as wound healing and a deeper understanding of inflammatory pathways and their manipulation through innovative biomaterials and regenerative techniques is urgently needed in order to promote clinically meaningful outcomes.

This research topic aims to address the need for investigation on how immune responses influence the success of regenerative therapies, from acute-phase to chronic inflammatory states. Contributions may explore how cellular therapies and autologous micrografts affect regenerative therapies or how dermal substitutes and bioengineered scaffolds support vascularization, reduce scar formation, and promote functional tissue integration. By bridging immunology with tissue engineering, this topic seeks to identify critical checkpoints, therapeutic windows, and biomolecular targets that could lead to more personalized and effective regenerative approaches.

We welcome original research articles, reviews, case series, and translational studies that explore the molecular, cellular, and clinical aspects of inflammation and regeneration. Submissions may include in vitro or in vivo investigations, biomaterial-host interactions, wound healing and more. Manuscripts focusing on the use of autologous tissue-derived micrografts, advanced dermal matrices, or the results of regenerative therapies in vascularization, scar reduction and functional tissue integration are particularly encouraged. Additionally, we seek contributions that evaluate regenerative interventions in both acute and chronic clinical scenarios, including complex wounds and burns and also comparative studies between conventional wound care and regenerative interventions. This topic will serve as a platform for multidisciplinary collaboration between immunologists, surgeons and bioengineers aiming to push the boundaries of regenerative medicine.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Regenerative medicine, wound healing, inflammatory response, reconstructive therapy, bioengineering

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.