Celebrating 45 Years of the Chilean Society of Pharmacology, Volume II

Pharmacology is defined as the discipline that investigates the effects of chemical agents on the physiological and pathological functions of living organisms. As such, it represents fundamentally translational science, bridging molecular, biochemical, and biomedical research with clinical practice. The establishment and expansion of Pharmacological Societies worldwide have played—and will continue to play—a critical role in fostering the integration of basic, experimental, and clinical pharmacological sciences. In this context, the Chilean Society of Pharmacology (Sociedad de Farmacología de Chile, SOFARCHI), founded in 1978 by a group of Chilean pharmacologists, commemorates its 45th anniversary. SOFARCHI is a non-profit scientific organization committed to advancing pharmacological research across theoretical, experimental, and clinical domains. Beyond its scientific mission, the Society has also prioritized public education on the rational use of medications, highlighting both therapeutic benefits and potential adverse effects. Over the past decade, SOFARCHI has undergone significant institutional growth, with active membership surpassing 250 researchers. As a result, its Annual Meeting has become one of the most prominent scientific gatherings in Chile, serving as a vital platform for the dissemination and discussion of pharmacological advances.

The Chilean Society of Pharmacology encompasses a diverse array of research strengths, with its members demonstrating outstanding contributions in several specialized areas. These include the pharmacology of neurodegenerative disorders, modulation of inhibitory ion channels, characterization of neuroactive compounds derived from Chilean native flora, dopaminergic and purinergic signaling, regulation of cardiac fibroblast activity, gut–brain axis pharmacology, and pharmacogenomics in Latin American populations, among others.

In 2020, in collaboration with Frontiers in Pharmacology the Society celebrated its 40th anniversary with the Research Topic “Celebrating 40 Years of the Chilean Society of Pharmacology .” To commemorate the Society’s 45th anniversary and highlight both scientific progress and public engagement since then, this Research Topic aims to showcase original research articles, as well as reviews, commentaries, and perspectives that reflect recent advances and propose future directions in the pharmacological domains where SOFARCHI members have made significant contributions. Importantly, this Research Topic also welcomes high-quality submissions from researchers affiliated with other scientific societies, provided their work aligns with the scope of the featured specialty sections, including—but not limited to— Experimental Pharmacology and Drug Discovery, Translational Pharmacology, Neuropharmacology, Cardiovascular Pharmacology, Immunopharmacology, Medicinal Chemistry, and Gastrointestinal Pharmacology.