Lipid biomarkers, including common measures such as cholesterol and triglycerides as well as newer indicators like lipoproteins, apolipoproteins, and lipidomic profiles, are increasingly recognized as key drivers of cardiometabolic risk. Endocrine disorders such as diabetes, obesity, thyroid disease, adrenal disorders, and polycystic ovary syndrome are often linked to disruptions in lipid metabolism. These changes not only contribute to atherosclerosis, insulin resistance, and inflammation but also overlap with hormonal pathways that regulate metabolic balance. Recent progress in lab methods and systems-level research has provided deeper insights into how lipid biomarkers, endocrine function, and cardiometabolic outcomes interact. Understanding this connection is essential for improving risk assessment, uncovering mechanisms, and guiding more personalized treatment strategies in endocrinology.
This Research Topic aims to highlight new findings on how lipid biomarkers can be used to predict, monitor, and reduce cardiometabolic risk in the setting of endocrine disorders. By combining basic, clinical, and translational perspectives, we hope to uncover novel biomarkers, clarify their role in endocrine disease, and explore their potential as treatment targets. This collection also seeks to foster dialogue across endocrinology, cardiometabolism, and lipid research, with the goal of advancing both scientific understanding and patient care in endocrine-related metabolic dysfunction.
We welcome submissions addressing, but not limited to, the following areas:
• Identification and validation of lipid biomarkers in endocrine disorders (e.g., diabetes, obesity, thyroid and adrenal diseases, PCOS).
• Mechanistic links between lipid metabolism, hormonal signaling, and endocrine regulation.
• Roles of apolipoproteins, lipoprotein subfractions, and novel lipidomic profiles in cardiometabolic risk
• Clinical and translational studies on lipid biomarkers as predictors of cardiovascular events.
• Multi-omics, systems biology, and precision medicine integrating lipid, endocrine, and metabolic pathways.
• Inflammation, oxidative stress, and vascular dysfunction as mediators of lipid-endocrine alterations.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Community Case Study
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
