Molecular Mechanisms and Innovative Therapies for Advancing Cancer Treatment

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ORIGINAL RESEARCH

Published on 31 Aug 2026

Network pharmacology and experimental evidence of the anti-colorectal cancer potential of Xian Lian Jie Du formula: quercetin, kaempferol and luteolin jointly inhibit the HIF1A/IL6/TNF oncogenic pathway

Ning Du
Li Ji
Lixing Liu
Xinqi Liu
Zhenglong Jiang
Yukun Yin
Li Feng

doi 10.3389/fonc.2026.1882054

744 views

ORIGINAL RESEARCH

Published on 13 Aug 2026

Umbralisib antagonizes multidrug resistance in ABCB1-overexpressing cancer cells

Letao Bo
Bohan Zhang
Xuan-Yu Chen
Xuanming Mao
Luke Zhong
Meizi Tan
Mingyu Cui
Harsh Patel
John N. D. Wurpel
Zhe-Sheng Chen

doi 10.3389/fonc.2026.1916572

567 views

ORIGINAL RESEARCH

Published on 11 Aug 2026

RPLP0 identified as a ferroptosis regulator in HCC through pan-cancer analysis

Zuli Wang
Shuai Chen
Bokang Yan
Xintong Peng
Ling Chen
Min Su
Haiyang Li

doi 10.3389/fonc.2026.1891222

933 views

REVIEW

Published on 22 Jul 2026

Emerging ImmunoPET probes for precision cancer immunotherapy: molecular targets and translational applications

Ting Liu
Jiamao Lin
Yang Li
Yong Wang

doi 10.3389/fonc.2026.1893952

883 views

REVIEW

Published on 21 Jul 2026

Inflammatory myofibroblastic tumour: unravelling the interplay of inflammation, kinase signalling, and therapeutic resistance

Sara Maiti
Archana Rose Reji
Swathi Senthil
Rakshana R.
Rekha Solairaju
Rehana Kunjumon
Payel Ghosh
Syama H.P.
Pritam Sadhukhan
Arkajyoti Dutta

doi 10.3389/fonc.2026.1891320

1,211 views

ORIGINAL RESEARCH

Published on 20 Jul 2026

From patient-derived tumor organoids to personalized cancer therapy: advancing treatment for advanced solid tumors

Gang Wang
Zhibin Tan
Wenting Jia
Yuanyuan Liu
Huan Wang
Wenbo Sun
Weiwei Sun
Lu Meng
Yudong Zhang
2 more
Hongchao Dong

doi 10.3389/fonc.2026.1880986

1,002 views

REVIEW

Published on 15 Jul 2026

Research progress of small molecule targeted drugs for non-small cell lung cancer

Tingxiang Qiu
Xin Huang

doi 10.3389/fonc.2026.1847493

1,838 views

ORIGINAL RESEARCH

Published on 02 Jul 2026

Repurposing tricyclic drugs as cancer therapeutics: comparative analysis of antitumorigenic effects of chlorpromazine, amitriptyline and imipramine

Joos Berghausen
Eric Glasgow
Tinatin I. Brelidze

doi 10.3389/fonc.2026.1827698

1,335 views

REVIEW

Published on 25 May 2026

The international and domestic research trends of targeted therapy in bladder cancer: a bibliometric analysis of the past three decades

Yijin Pan
Yu Sun
Binbin Jiao
Yinqiang Zhang
Guan Zhang

doi 10.3389/fonc.2026.1850175

2,811 views

PERSPECTIVE

Published on 20 May 2026

Nanomaterial-based strategies to overcome sorafenib resistance in hepatocellular carcinoma: from mechanistic insights to translational applications

Jinbang Huang
Shi Huang
Wenjing Chen
Shunsheng Wang
Zhihao Zuo
Xinyan Wu
Gang Deng

doi 10.3389/fonc.2026.1839966

1,420 views

ORIGINAL RESEARCH

Published on 23 Apr 2026

Mechanistic drivers of PD-L1/CTLA-4 checkpoint inhibitor–associated immune toxicity and systemic organ injury

Junfeng Chen
Lin Zhang
Minqqiang Gao
Siqing Min

doi 10.3389/fonc.2026.1808024

1,279 views

BRIEF RESEARCH REPORT

Published on 22 Apr 2026

Phase II study of magrolimab combined with docetaxel in previously treated metastatic advanced solid tumors

Antoine Italiano
Teresa García Manrique
Enrique Grande Pulido
Katie Kerrigan
Aude Fléchon
Julia Martínez Pérez
Bogdan Żurawski
Muhammad Furqan
Oscar Juan-Vidal
10 more
Luis Paz-Ares

doi 10.3389/fonc.2026.1786385

1,993 views
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Frontiers in Oncology

Cancer Molecular Targets and Therapeutics

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Articles

Network pharmacology and experimental evidence of the anti-colorectal cancer potential of Xian Lian Jie Du formula: quercetin, kaempferol and luteolin jointly inhibit the HIF1A/IL6/TNF oncogenic pathway

Umbralisib antagonizes multidrug resistance in ABCB1-overexpressing cancer cells

RPLP0 identified as a ferroptosis regulator in HCC through pan-cancer analysis

Emerging ImmunoPET probes for precision cancer immunotherapy: molecular targets and translational applications

Inflammatory myofibroblastic tumour: unravelling the interplay of inflammation, kinase signalling, and therapeutic resistance

From patient-derived tumor organoids to personalized cancer therapy: advancing treatment for advanced solid tumors

Research progress of small molecule targeted drugs for non-small cell lung cancer

Repurposing tricyclic drugs as cancer therapeutics: comparative analysis of antitumorigenic effects of chlorpromazine, amitriptyline and imipramine

The international and domestic research trends of targeted therapy in bladder cancer: a bibliometric analysis of the past three decades

Nanomaterial-based strategies to overcome sorafenib resistance in hepatocellular carcinoma: from mechanistic insights to translational applications

Mechanistic drivers of PD-L1/CTLA-4 checkpoint inhibitor–associated immune toxicity and systemic organ injury

Phase II study of magrolimab combined with docetaxel in previously treated metastatic advanced solid tumors

Frontiers in Oncology

Cancer Molecular Targets and Therapeutics