Neurological biomarkers for drug delivery systems in Blood–Brain Barrier research

The blood–brain barrier (BBB) is a highly selective, semipermeable border of endothelial cells that protects the brain from potentially harmful substances in the bloodstream while allowing the passage of essential nutrients. While this protective function is vital for maintaining central nervous system (CNS) homeostasis, it also presents a formidable challenge for the delivery of therapeutic agents to treat neurological diseases such as Alzheimer's, Parkinson’s, brain tumors, epilepsy, and multiple sclerosis.

In recent years, the integration of neurological biomarkers in drug delivery system (DDS) design has emerged as a promising strategy to overcome BBB-related delivery challenges. The development of new strategies for overcoming the BBB is considered essential, and a target-oriented approach with the use of nanotechnology may pave the way for more effective and controlled treatment of not only epilepsy but also other neurodegenerative diseases as well. This research topic focuses on identifying, validating, and utilizing neurological biomarkers to facilitate and monitor the transport of drugs across the BBB.

This Research Topic aims to consolidate the latest efforts and innovations in utilizing neurological biomarkers to enhance drug delivery across the BBB. The objective is to gather research that addresses key aspects of biomarker identification, validation, and application for targeted DDS strategies, as well as to explore novel techniques for real-time tracking of therapeutic transport and distribution in the CNS. By fostering interdisciplinary dialogue, this Research Topic seeks to advance translational research with the potential to transform CNS disease treatment paradigms.

To gather further insights in the targeted manipulation of blood–brain barrier transport using neurological biomarkers, we welcome articles addressing, but not limited to, the following themes:

Identification and validation of neurological biomarkers for BBB targeting and monitoring
Nanotechnology and biomaterial-based platforms for targeted CNS drug delivery
Innovative drug delivery system designs responsive to biomarker signals
Strategies for real-time tracking and imaging of drug transport across the BBB
Preclinical and clinical evaluation of biomarker-guided therapies for neurodegenerative and neuroinflammatory diseases
Safety, efficacy, and regulatory considerations for biomarker-driven DDS development

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review

Keywords: molecular and cellular biomarkers, imaging biomarkers, biofluid biomarkers, targeted drug delivery systems, disease-specific models, clinical translation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.