New Paradigms for Diagnosis and Treatment for NSCLC: From Wet Lab to Precision Medicine

Research in non-small cell lung cancer (NSCLC) has made considerable strides in recent years, particularly in the context of molecular biology, genomics, and precision medicine. NSCLC is one of the leading causes of cancer-related mortality worldwide, prompting a significant push towards more accurate diagnostic methods and targeted treatment strategies. Despite these advances, challenges remain in understanding the complexity of NSCLC at a molecular level, identifying precise biomarkers, and developing personalized treatment protocols that can be widely implemented.

Recent studies highlight the importance of integrating genomic research with clinical practice to enhance diagnostic and therapeutic outcomes for NSCLC patients. Breakthroughs in biomarker discovery, next-generation sequencing, and the advent of immunotherapies are reshaping conventional treatment approaches. These innovations are not merely academic; they translate into real-world clinical settings, offering patients more personalized and effective care options. However, the transition from bench to bedside is still fraught with obstacles, requiring continued investigation and refinement.

This Research Topic aims to explore the cutting-edge developments in NSCLC diagnosis and treatment with a focus on transitioning from laboratory findings to clinical application. By emphasizing the role of precision medicine, we aim to shed light on effective strategies that can improve patient outcomes through personalized healthcare solutions. To gather further insights into the evolving landscapes in NSCLC care, we welcome articles addressing, but not limited to, the following themes:

- Molecular and genomic insights into NSCLC
- Biomarker identification and validation
- Advances in diagnostic imaging and techniques
- Personalized and targeted treatment approaches
- Immunotherapy advancements and clinical implementation


Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Non-small cell lung cancer (NSCLC), Precision medicine, Molecular diagnostics, Genomic research, Biomarker identification, Next-generation sequencing (NGS).

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.