Community Series in: The Link Between Metabolic Syndrome and Chronic Kidney Disease: Focus on Diagnosis and Therapeutics - Volume III

This Research Topic is the third volume in this series, " Community Series in: The Link Between Metabolic Syndrome and Chronic Kidney Disease: Focus on Diagnosis and Therapeutics". Please see volume II here.

Metabolic syndrome (MetS), including obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia, are associated with disturbed energy homeostasis, limited whole-body insulin sensitivity, and an increased risk of cardiovascular and chronic kidney disease (CKD). The prospective and cross-sectional studies have shown a close association between the MetS and CKD. Chronic inflammation and vascular dysfunction are two key MetS-related etiological factors for renal injury. CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy at the cellular level, which is also typical of metabolic disorders. However, the relationship and mechanism between metabolic disease and chronic kidney dysfunction still call for deeper understanding. This Research Topic aims to gather both Reviews and Original Research articles focused on discovering the truth behind the phenomenon that glucose and lipid metabolic disorders and obesity have important public health implications in terms of individuals with CKD. The studies covering new insights to determine the link between MetS-related immunity response and renal dysfunction will also be considered.

In this Research Topic, we seek to provide a forum for recent advances on inherent renal cells and immunoreaction to identify the major contributors of metabolic disorders leading to kidney dysfunction. We welcome all investigators in the field to submit their laboratory, patient-oriented, and epidemiological research and clinical trials of new therapies.

Potential topics include but are not limited to the following:
• New insights of molecular and cellular pathobiology and pathophysiology on the relationship between metabolic syndrome and kidney dysfunction.
• Emerging roles for both the inherent renal cells and immune cells in chronic kidney injury induced by metabolic disorder.
• Novel therapeutic strategies on vascular-metabolic dysfunction in CKD.
• Clinical studies with a focus on CKD in metabolic syndrome patients: diagnosis, molecular signaling and cellular mechanisms, and treatment strategy.