Novel immunotherapeutic strategies for HIV cure

Despite the success of antiretroviral therapy (ART) in controlling HIV replication, a definitive cure remains elusive due to the persistence of latent viral reservoirs and immune dysfunction. Recent advances in immunotherapy have opened new avenues for targeting these reservoirs and enhancing immune-mediated clearance of HIV-infected cells. From immune checkpoint blockade to T cell engagers, to engineered cellular therapies, the field is rapidly evolving, offering promising strategies to overcome the barriers to cure. This Research Topic aims to explore innovative immunotherapeutic approaches and their potential to transform HIV cure research.

This Research Topic seeks to address the critical challenge of eradicating HIV by leveraging the power of the immune system. We aim to highlight cutting-edge research that identifies and exploits novel immunological mechanisms and therapeutic targets. By fostering interdisciplinary dialogue between immunologists, virologists, and clinical researchers, this issue will advance our understanding of how immune-based interventions can contribute to a HIV control and eradication. We particularly encourage submissions that present innovative strategies, mechanistic insights, and translational potential in the context of HIV immunotherapy.

We welcome researchers to submit Perspectives, Original Research articles and Reviews, exploring novel immunotherapeutic strategies aimed at achieving an HIV cure, including but not limited to the following subtopics:
• Original research on novel immunomodulatory agents or mechanisms
• Studies identifying and validating new therapeutic targets
• Investigations into immune mechanisms of reservoir persistence and clearance
• Preclinical or early-phase clinical data on immunotherapeutic interventions
• Perspectives or reviews on emerging trends in HIV immunotherapy

The scope of this Research Topic includes mechanistic insights, identification of new drug targets, and translational approaches that bridge basic immunology and clinical application.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: HIV cure, immunotherapy, viral reservoirs, immune modulation, drug targets, latency reversal, immune checkpoint inhibitors, cell therapies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.