Research Topic

Genetic and Molecular Robustness in Cell and Developmental Biology

About this Research Topic

A biological system is robust if it continues to function in face of perturbations. Genetic robustness is the capacity of organisms to withstand mutations, showing little or no phenotype, or compromised viability. This inherent property of biological systems is wired in the genetic and proteomic interactome and enhances the chance of viability of individuals in face of mutations. So far, we know that, just like microorganisms and invertebrates, vertebrate species are also very robust to mutations, as most genes will not show an overt phenotype when mutated and will generate viable individuals. This poses two fundamental questions: 1. How can we study the function of particular genes despite of the robustness? and 2. How does the system compensate for the lack of function of these genes? In other words, what are the mechanisms behind genetic robustness.

Even though robustness is present at every level of organization in cell and developmental biology, few studies address how this phenomenon is manifested and which are the genetic, biochemical and cellular mechanisms that enable it. The aim of this Research Topic is to bring together current research in cell and developmental biology that either: 1. Describes a robust feature in a specific system or 2. Addresses the mechanism behind a robust property in a system.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A biological system is robust if it continues to function in face of perturbations. Genetic robustness is the capacity of organisms to withstand mutations, showing little or no phenotype, or compromised viability. This inherent property of biological systems is wired in the genetic and proteomic interactome and enhances the chance of viability of individuals in face of mutations. So far, we know that, just like microorganisms and invertebrates, vertebrate species are also very robust to mutations, as most genes will not show an overt phenotype when mutated and will generate viable individuals. This poses two fundamental questions: 1. How can we study the function of particular genes despite of the robustness? and 2. How does the system compensate for the lack of function of these genes? In other words, what are the mechanisms behind genetic robustness.

Even though robustness is present at every level of organization in cell and developmental biology, few studies address how this phenomenon is manifested and which are the genetic, biochemical and cellular mechanisms that enable it. The aim of this Research Topic is to bring together current research in cell and developmental biology that either: 1. Describes a robust feature in a specific system or 2. Addresses the mechanism behind a robust property in a system.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

28 February 2019 Abstract
30 May 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

28 February 2019 Abstract
30 May 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);