Advanced Nanotechnology for Reactive Oxygen Species (ROS)-mediated Therapies

Background
Reactive oxygen species (ROS) play an important role in regulating various physiological functions of living entities. The intrinsic biochemical properties of ROS make it necessary for the physiological signaling and biological processes, while excess ROS levels can lead to cellular damage or various diseases. These can include neurological disorders, cardiovascular diseases, inflammation and cancer. Many efforts have been made to reveal the underlying chemical and biological effects of these chemical species and take full advantage of it for contributing to medical therapeutics. However, how we can finely regulate ROS to initiate therapeutic effects is an issue which remains to be settled.

Goals
Currently, the research in this field focuses on the mechanistic role of ROS in different biological and chemical processes. The detection, quantification, and kinetics evaluation of ROS in vitro and in vivo are essential to better understand these processes. Revolutionary technologies, such as nanotechnology, are employed for the development of ROS-based nanomedicines with unique ROS-regulating properties. This Research Topic aims to provide researchers with a platform to publish original, innovative, and state-of-the art research articles as well as reviews in ROS-related research interests.

Scope and Information for Authors
Types of manuscripts to be featured include Original Research, Review, Mini-Reviews and Perspective articles. Themes to be investigated may include, but are not limited to：
• The investigation of the role of ROS in biological and/or chemical processes
• The different spectroscopic, electrochemical and biochemical methods for the detection of ROS
• Novel strategies to regulate ROS for disease management 
• Development of ROS based nanomaterials
• ROS-mediated combination therapy
• Modulation of ROS for cachexia therapy
• ROS-mediated cancer immunotherapy mechanisms
• Protein nanoparticles for treatment of various ROS-related diseases
• ROS-triggered drug delivery system
• Mechanisms of Immune cell therapy
• Direct reprogramming (transdifferentiation)