Trauma and infection-caused osseous-ligament defects have become a constant threat to limb function and quality of life, which should be taken seriously. Severe osseous-ligament defects caused by trauma occur frequently, such as comminuted fractures, torn ligaments, and especially injuries with open wounds. Biomaterials for osseous-ligament regeneration are a branch of tissue engineering that faces the risk of infection despite significant advances made over the decades in cartilage, ligament, and bone repair. Protection against infection as well as quality and function poses a major challenge to the science of biomaterials for tissue repair. Good biomaterials should be of suitable quality to enhance tissue growth and restore function and should not have negative effects on immunity and the ability to fight infection.
In this research topic, we would like to introduce the recent developments of biomaterials and corresponding therapies for the osseous-ligament systems, including synthetic materials, natural biomaterials, antimicrobial materials, etc. Novel biomaterials and antimicrobial compounds including small molecules, peptides and polymers will be presented in this topic. Special attention will be paid to the advanced mechanisms of action that do not induce resistance. We would also like to discuss the mechanism and function of biomaterials during treatment or in vivo studies. On the regenerative side, we will present the design and fabrication of the scaffold to better stimulate the natural spatial complexity of cell types and tissue organization of bone and joints. In terms of safety and efficacy, we will discuss biomaterial integration, biocompatibility and inflammation in the host, and the successful survival of the implant in the host body.
We welcome any manuscript that addresses the challenges of antibacterial strategy and tissue engineering, especially bone repair. We particularly encourage the submission of manuscripts in the following areas, but not limited to:
- Novel synthetic biomaterials, polymers, peptides, and peptidomimetics.
- Biomaterials (hydrogels, fibers, surfaces, coatings, or natural biomaterials) for osseous-ligament reconstruction.
- Bactericidal mechanisms of action that do not induce resistance trait.
- Selective targeting with bacterial recognition molecules.
- Intelligent and on-demand delivery system with bacterial-driven activation.
- Modulating stem cell differentiation and chondrocyte redifferentiation.
- Promotion of survival and integration of implants in cartilage, ligaments, and bone.
- Additive manufacturing of scaffolds for tissue engineering of bone and cartilage.
- Translational research on tissue engineering of bone and joints.
Trauma and infection-caused osseous-ligament defects have become a constant threat to limb function and quality of life, which should be taken seriously. Severe osseous-ligament defects caused by trauma occur frequently, such as comminuted fractures, torn ligaments, and especially injuries with open wounds. Biomaterials for osseous-ligament regeneration are a branch of tissue engineering that faces the risk of infection despite significant advances made over the decades in cartilage, ligament, and bone repair. Protection against infection as well as quality and function poses a major challenge to the science of biomaterials for tissue repair. Good biomaterials should be of suitable quality to enhance tissue growth and restore function and should not have negative effects on immunity and the ability to fight infection.
In this research topic, we would like to introduce the recent developments of biomaterials and corresponding therapies for the osseous-ligament systems, including synthetic materials, natural biomaterials, antimicrobial materials, etc. Novel biomaterials and antimicrobial compounds including small molecules, peptides and polymers will be presented in this topic. Special attention will be paid to the advanced mechanisms of action that do not induce resistance. We would also like to discuss the mechanism and function of biomaterials during treatment or in vivo studies. On the regenerative side, we will present the design and fabrication of the scaffold to better stimulate the natural spatial complexity of cell types and tissue organization of bone and joints. In terms of safety and efficacy, we will discuss biomaterial integration, biocompatibility and inflammation in the host, and the successful survival of the implant in the host body.
We welcome any manuscript that addresses the challenges of antibacterial strategy and tissue engineering, especially bone repair. We particularly encourage the submission of manuscripts in the following areas, but not limited to:
- Novel synthetic biomaterials, polymers, peptides, and peptidomimetics.
- Biomaterials (hydrogels, fibers, surfaces, coatings, or natural biomaterials) for osseous-ligament reconstruction.
- Bactericidal mechanisms of action that do not induce resistance trait.
- Selective targeting with bacterial recognition molecules.
- Intelligent and on-demand delivery system with bacterial-driven activation.
- Modulating stem cell differentiation and chondrocyte redifferentiation.
- Promotion of survival and integration of implants in cartilage, ligaments, and bone.
- Additive manufacturing of scaffolds for tissue engineering of bone and cartilage.
- Translational research on tissue engineering of bone and joints.
