function and quality of life, which inflict serious health problems to millions of people worldwide and cause major economic burdens to society (Niu et al., 2023). Severe osseousligament defects caused by trauma occur frequently, such as comminuted fractures, torn ligaments, and injuries with open wounds. As a burgeoning branch of tissue engineering, biomaterials for osseous-ligament regeneration face a constant risk of infection despite significant advances made over the decades in cartilage, ligament, and bone repair (Shen et al., 2022). Protection against infection as well as quality and function pose a major challenge to the science of biomaterials for tissue repair. Effective biomaterials should be of suitable quality to enhance tissue growth and restore function and should not have negative hindrances on immunity and the ability to fight infection.In this issue, we introduce the recent developments of biomaterials and corresponding therapies for the osseous-ligament systems, including synthetic materials, natural biomaterials, and antimicrobial materials. We also compile the mechanism and function of biomaterials during treatment or in vivo studies. On the regenerative side, we present the design and fabrication of the scaffold to better stimulate the natural spatial complexity of cell types and tissue organization of bone and joints. In terms of safety and efficacy, we discuss biomaterials integration, biocompatibility and inflammation in the host, and the successful survival of the implant in the host body. From the compilation of these individual contributions, the collective articles are broad in nature, ranging from initial research to clinical applications that address the challenges of antibacterial strategy and tissue engineering in bone repair. This issue therefore provides references for ongoing research in natural and synthetic biomaterials (hydrogels, fibers, surfaces, coatings, polymers, peptides, and peptidomimetics) for osseous-ligament reconstruction. It encourages future directions in antibacterial functions, modulation of stem cell differentiation and chondrocyte redifferentiation, promotion of survival and integration of implants in ligaments and bone, additive manufacturing of scaffolds for tissue engineering of bone and cartilage, and translational research on tissue engineering of bone and joints.
5 Authors
- XW
Xinyi Wang
Affiliated Zhongshan Hospital of Dalian University, China
- KZ
Ke Zhou
Affiliated Zhongshan Hospital of Dalian University, China
- YL
Yada Li
Affiliated Zhongshan Hospital of Dalian University, China
- HX
Hui Xie
Affiliated Zhongshan Hospital of Dalian University, China
- BW
Benjie Wang
Affiliated Zhongshan Hospital of Dalian University, China
9 Authors
- ZH
Zhuowen Hao
Department of Orthopedics, China
- RC
Renxin Chen
Department of Orthopedics, China
- CC
Chen Chai
Emergency Center, China
- YW
Yi Wang
Department of Orthopedics, China
- TC
Tianhong Chen
Department of Orthopedics, China
- HL
Hanke Li
Department of Orthopedics, China
- YH
Yingkun Hu
Department of Orthopedics, China
- QF
Qinyu Feng
Department of Orthopedics, China
- JL
Jingfeng Li
Department of Orthopedics, China
8 Authors
- NG
Na Guo
Department of Computer Science and Technology, China
- JT
Jiawen Tian
Department of Computer Science and Technology, China
- LW
Litao Wang
College of Engineering, China
- KS
Kai Sun
Department of Biomedical Engineering, China
- LM
Lixin Mi
Musculoskeletal Department, China
- HM
Hao Ming
Orthopaedics, China
- ZZ
Zhao Zhe
Department of Biomedical Engineering, China
- FS
Fuchun Sun
Department of Computer Science and Technology, China
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