This Research Topic will review connexins, pannexins and cell death, looking at the various ways these channel proteins are involved in signaling that regulates apoptosis, necrosis, etc. These roles are often tissue specific and contribute to tissue function in health and disease, including in the skin (wound healing), gut, ovary, eye, and throughout the nervous system; both channel families are also important during embryogenesis and across development. Pannexin and connexin signaling may promote or restrict distinct forms of cell death depending on environment/tissue as either part of normal tissue turnover or in response to disease or injury. For connexins, different gap junction subtypes have unique roles in cell function and death. While distinct pannexin family members promote apoptosis or regulate necrosis in tissue- and cell-type specific mechanisms.
The goal of this Research Topic is to bring together work that explores the role of connexin and pannexin signaling in cell death (both in tissue health and disease), with the aim of increasing the understanding of the biology of this area and feeding into work to develop new related therapies to improve conditions such as delayed wound healing, compromised gut health, and neuroprotection.
We would be interested in receiving both reviews and research articles for this collection. The scope is to be within the area of the interactions of connexins, pannexins and cell death in tissue health and disease.
This Research Topic will review connexins, pannexins and cell death, looking at the various ways these channel proteins are involved in signaling that regulates apoptosis, necrosis, etc. These roles are often tissue specific and contribute to tissue function in health and disease, including in the skin (wound healing), gut, ovary, eye, and throughout the nervous system; both channel families are also important during embryogenesis and across development. Pannexin and connexin signaling may promote or restrict distinct forms of cell death depending on environment/tissue as either part of normal tissue turnover or in response to disease or injury. For connexins, different gap junction subtypes have unique roles in cell function and death. While distinct pannexin family members promote apoptosis or regulate necrosis in tissue- and cell-type specific mechanisms.
The goal of this Research Topic is to bring together work that explores the role of connexin and pannexin signaling in cell death (both in tissue health and disease), with the aim of increasing the understanding of the biology of this area and feeding into work to develop new related therapies to improve conditions such as delayed wound healing, compromised gut health, and neuroprotection.
We would be interested in receiving both reviews and research articles for this collection. The scope is to be within the area of the interactions of connexins, pannexins and cell death in tissue health and disease.
