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Non-Cell Cycle Functions of Cell Cycle Regulators

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Front. Cell Dev. Biol. | doi: 10.3389/fcell.2018.00161

Spindle Checkpoint Regulators in Insulin Signaling

  • 1University of Texas Southwestern Medical Center, United States
  • 2Howard Hughes Medical Institute (HHMI), United States

The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes. These critical pathways have been extensively investigated, but a link between the two has not been established until recently. Our recent study reveals a critical role of spindle checkpoint regulators in insulin signaling and metabolic homeostasis through regulating endocytosis of the insulin receptor (IR). These findings have linked spindle checkpoint proteins to metabolic regulation, expanding the connection between cell division and metabolism. Here, we briefly review the unexpected roles of spindle checkpoint regulators in vesicle trafficking and insulin signaling.

Keywords: spindle checkpoint, Mitosis, insulin signaling, Endocytosis, Insulin receptor, Evolutionary repurposing

Received: 16 Oct 2018; Accepted: 08 Nov 2018.

Edited by:

Gordon Chan, Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, Canada

Reviewed by:

Sabine Elowe, Laval University, Canada
Tim J. Yen, Fox Chase Cancer Center, United States  

Copyright: © 2018 Yu and Choi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Hongtao Yu, University of Texas Southwestern Medical Center, Dallas, United States, hongtao.yu@utsouthwestern.edu