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Front. Energy Res., 15 August 2022
Sec. Nuclear Energy
Volume 10 - 2022 |

An Evaluation of the Data-Driven Model for Bubble Maximum Diameter in Subcooled Boiling Flow Using Artificial Neural Networks

www.frontiersin.orgXiaomeng Dong1*, www.frontiersin.orgHaoxian Chen1, www.frontiersin.orgChangwei Li1, www.frontiersin.orgMing Yang1, www.frontiersin.orgYang Yu2* and www.frontiersin.orgXi Huang1
  • 1Institute for Advanced Study in Nuclear Energy & Safety, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China
  • 2Nuclear Power Institute of China, Chengdu, China

In the subcooled boiling flow under low-pressure conditions, bubble characteristic diameter is of great influence on the surface heat transfer coefficient. However, large errors are still found in calculations using traditional mechanistic models or empirical correlations, especially for wide experimental condition. In this paper, we propose a widely applicable data-driven model using artificial neural networks (ANN) to predict the bubble maximum diameter and investigate the effect of experimental conditions. After a series of analyses on structural parameters and input parameters, the ANN model is established and validated based on six available experimental databases. The result shows that the relative error is around 14%. Uncertainty analysis is carried out for the four experimental conditions and two structural conditions. The results show the measuring accuracy of pressure is one of the most sensitive parameters on the prediction of bubble maximum diameter in the subcooled boiling flow under 1.0 MPa, especially for the bubble sizes larger than 0.5 mm. According to the results of uncertainty analysis, a new correlation is proposed for coefficients C and φ, which are used to express the effect of pressure and fluid dynamic. The new correlation works well for all the experimental databases, and the error for bubble datasets of large size is also modified. Furthermore, another independent validation with a low relative error to 14% is provided to prove the accuracy of the new correlation.

1 Introduction

In a typical pressurized water reactor, saturation of boiling phenomenon is not allowed for its impairment to the fuel element. However, subcooled boiling flow may potentially occur in some special positions, such as the outlet of the fuel assembly or corners beside the spacer grid. The phase change could bring about a large increase in heat transfer efficiency of the heated surface. In complicated experiments involving a reactor core, the heat flux of the cladding surface is difficult to control precisely. Boiling crises determined by critical heat flux (CHF) may occur under some accident conditions. The CHF is a complicated two-phase flow phenomenon, characterized by a heat transfer mechanism change that rapidly decreases the efficiency of the heat transfer performance and increases the temperature of the heater surface. The high temperature could melt the fuel cladding and significantly damage the reactor core.

In general, the gas phase is always present in the form of bubbles during the subcooled boiling process. It features a series of action according to the effects of heat and fluid dynamics, such as generation, growth, sliding, and lift-off. In the subcooled boiling flow, the coefficient of the convective heat transfer is influenced by the characteristic parameters and dynamic behaviors of bubbles, their size and shape in particular. To describe the heat exchange and the heat flux partition on the heated surface in a theoretical view, the Rensselaer Polytechnic Institute (RPI) model (Kurul and Podowski, 1991) is widely used in the simulation of subcooled boiling flow. In this mechanistic model, the characteristic bubble diameter is considered one of the most important parameters, and it should be calculated accurately.

In the subcooled boiling flow, the characteristic bubble size has three main features, the maximum, departure, and lift-off diameter, which is shown in Figure 1. The maximum bubble diameter describes the limited size of growth for bubbles adjacent to the heated surface, while the other two parameters refer to the patterns of movement of the bubbles during the growth process.


FIGURE 1. The sketch map of bubble characteristic size. (A) Bubble maximum diameter, (B) bubble departure diameter, (C) bubble lift-off diameter.

There are few differences among these three parameters. However, the maximum bubble diameter and lift-off diameter are usually considered to be the same for the low and medium pressure conditions. Furthermore, the three bubble sizes show less of a difference for the non-slip bubble in low pressure and velocity (Hoang et al., 2016; Yoo et al., 2018). In calculations using computational fluid dynamics (CFD) method, all of these three characteristic sizes can be used in the calculation of the void fraction, heat and mass transfer, wall temperature, and quenching process of the different conditions (Tu and Yeoh, 2002; Krepper et al., 2013; Cheung et al., 2014; Gu et al., 2017).

Many approaches have been developed to calculate the bubble diameter, and these can be divided into three classifications, namely, empirical correlation, heat balance model, and force analysis model. Empirical correlations are proposed using the fitting of experimental databases. These usually contain several non-dimensional numbers, gradients, and ratios. Continuous multiplication and polynomial structure are a common functional form in the correlations, such as the model proposed by Prodanovic et al. (2002) and Brooks and Hibiki (2015). Certainly, these models show good performance for their own database. As the data expand and reach a larger scope, not all of the models could give the accurate results. Murallidharan et al. (2018) developed a bubble growth model that includes infinite bubble growth, wall effect multiplier, and bulk effect multiplier. Most of the coefficients in this model are fitted into polynomial structures. Although the model shows a good applicability over a wide range of conditions, it lacks any convenience of application and suitability for new experimental databases.

Apart from the empirical correlation, force balance and heat balance theories are used to calculate the characteristics bubble sizes from a theoretical view. According to the basic principle, the force balance model (Klausner et al., 1993; Situ et al., 2005; Yeoh et al., 2008) is suitable for calculating the departure and lift-off diameters of the bubbles, and the heat balance model (Ünal, 1976) is used to calculate the maximum diameter of the bubble. As can be seen from the application (Dong and Zhang, 2021) of these two models, the relative errors of the wide experimental databases reach around 40%. In reality, not all of the experiments provide local wall superheating as a result of immature measurement. The Chen correlation is always used for the calculation of wall superheat, especially in the heat balance model (Hoang et al., 2016; Dong and Zhang, 2021). This is the most accurate model for wall superheating, and its relative error is around 20%, which is a large proportion of the total error in the maximum bubble diameter.

Three submodules beyond wall superheating reflect the influence of pressure, velocity, and local subcooling. The former two are empirical correlations, while a partially mechanistic model is provided for the effects of local subcooling (Ünal, 1976). Because they were proposed in Ünal’s original heat balance model, almost no modification has been made for over 40 years. Dong and Zhang (2021) used Reynolds numbers instead of velocity values, which decreases the relative error by about 5–10%. After the investigation of several experimental databases, a more accurate model should be proposed to describe the effects of pressure on the characteristic bubble sizes in the future.

Thanks to the successful application of data mining techniques, data-driven theory has been used in many areas of industrial knowledge, such as fluid dynamics and intelligent manufacturing. In the fluid dynamics and thermodynamics, many data-driven models have been used to identify of flow regimes (Salgado et al., 2010; Affonso et al., 2020; Aarabi Jeshvaghani et al., 2021) and predict boiling crises (Greenwood et al., 2017; Yan et al., 2021) using artificial neural networks (ANN). All the results show good performance in a wide experimental condition. The relative error of CHF is around 20% which is better than that of empirical correlation or mechanistic models. Jung et al. (2020) investigated the bubble size distribution in turbulent air-water bubbly flows by using multi-layer ANNs. Compared to the 20% error of traditional theoretical models, the results of the use of ANNs show average relative error of 4.98% for the given experimental datasets.

This study discusses the application of ANNs for the calculation of maximum bubble diameter. We also try to investigate the influence of several experimental conditions based on the trained ANN model. The conclusions of uncertainty analysis are helpful to correct the correlation of coefficients to reflect the effects of pressure and mass flux in a more accurate way.

2 Mechanistic and Artificial Neural Networks Models of Bubble Maximum Diameter

2.1 Mechanistic Models

Although there are differences among the proposed heat balance models, the key theoretical points are shared; these describe an equivalence between absorbed and released heat bubbles. As Figure 2 shows, the bubble is regarded as an approximate sphere, while the growth process is determined by the heat from thin liquid film qtf, from superheated liquid layer qsl, and heat qc, dissipated through the subcooled liquid at the upper-half surface. Although a dry patch at which the vapor is contacted with heated wall directly exists, its heat flux is neglected when the bubble reaches its maximum value.


FIGURE 2. Heat flux partition for a growing bubble in the subcooled boiling flow.

According to heat balance theory, the mechanistic model can be developed as Equation 1.


The heat flux components used in Equation 1 are described in detail (Levenspiel, 1959; Zuber, 1961; Sernas and Hooper, 1969) and are given as follows.


The model of qtf was developed by Sernas and Hoopers (1969) and was used in Ünal’s heat balance theory. Parameter γ is used to reflect the influence of the thermal properties of the heated wall. This is shown in Equation 3.


hc is the heat transfer coefficient for condensation. Based on the model developed by Levenspiel (1959), Ünal (1976) derived a model for condensation heat transfer coefficient, as follows:


where C and φ are determined by the pressure and velocity of liquid phase, respectively.

C={655.69×105(P105)0.25×1010P1.418  0.1MPaP1MPa1MPa<P17.7MPa(5)

Dong and Zhang (2021) provided a new model (Equation 7) for parameter φ using the Reynolds number instead of velocity. Rel is widely used to determine the flow status, which has a decisive role on the characteristic temperature distribution of superheated liquid layer. In addition, it can reflect the shape effect of flow channel.


The surface area ratio of each heat flux is also of great importance for the heat balance model. The surface area Atotal of the generated bubble can be divided into four parts, including the area of thin liquid film Atf, area of superheated liquid layer Asl, area of heat dissipation Ac, and area of dry patch Adryout. These five parameters can be described by the following equations.


In Equation 8, L, m, and n refer to the fractions of surface area for thin liquid film, superheated liquid layer, and condensation. Under the assumption that the dry patch shrinks and disappears when the diameter of the bubble reaches the maximum value, the sum of L, m and n should be equal to 1.

By substituting Eqs. 25, 7, and 8 into Equation 1, we obtain the basic equation for bubble diameter, as follows:


Using Ünal’s method and the Taylor series (Ünal, 1976), the approximate solution of bubble maximum diameter can be written as follows:


where f is a coefficient of the characteristic temperature used to reflect an inhomogeneous of superheated liquid layer.

2.2 Artificial Neural Networks

In addition to the mechanistic model, an ANN model is proposed to predict the maximum diameter of a bubble using the BP (Back-Propagation) algorithm. The ANN model is a two-layer feed-forward network with sigmoid hidden neurons and linear output neurons. All of the calculations are carried out on the MATLAB platform.

As we can see from Figure 3, the ANN model consists of one input layer, one or more hidden layers and one output layer. Several parameters are chosen as input elements after analysis of the experimental conditions. These elements should reflect the effects of experimental conditions, such as pressure, mass flow, hydraulic diameter, heat flux, local subcooling, and the physical thermal properties of a heated surface.


FIGURE 3. Schematic diagram of the ANN model.

For each neuron, an activation function is necessary to transforms the input value to the next hidden layer or the output layer. Commonly used activation functions include sigmoid/logistic, tansig, ReLU, and ELU. The main purpose of the activation function is to increase the non-linear ability of the ANN model.

The training algorithm is another important element of an ANN model. It is used to train the network and form a fixed model. However, it is very difficult to know which training algorithm will be most suitable for a given problem. This depends on many factors, including the complexity of the problem, the number of data points in the training set, and the number of weights and biases in the network. Different training algorithms should be compared to gain a good accuracy in the calculation.

The last key parameter is the coefficient of determination R, which represents the fitting degree between the experimental value and the calculated value. It varies from 0 to 1, with larger values being better. The function is expressed as follows:


where n is the quantity of dataset, yi^ represents the calculated value by ANN model, and yi is the experimental value.

3 Experimental Databases

As Table 1 shows, six experimental databases are used for the validation of ANN model. All of the experimental conditions are kept at low pressure and low velocity. The number of data points sum to 366, which is sufficient to execute an ANN.


TABLE 1. Experimental databases for the validation.

The experimental data published by Situ et al. (2005), Brooks et al. (2015) Brooks and Hibiki (2015), Ahmadi et al. (2012), Okawa et al. (2007) and Xu et al. (2014) include bubble lift-off diameters. These datasets of the experiment are measured using a high-speed video camera. In the original heat balance theory, Ünal assumed that the bubbles would not leave the heated surface when they reached their maximum diameter. In this paper, bubble lift-off diameter is regarded as same as maximum bubble diameter.

Analyzing the original heat balance theory and using Equation 3, we can identify a power relation between the maximum bubble maximum diameter and the other four important parameters of the mechanistic model. The thermal properties of heated surface are not used as an impact parameter for the limited data of surface material. As can be seen in Equation 5, the direct influence of pressure P is worked through the parameter C. After integration, the order x of P should be in the range (-0.5, 0]. Considering that the vapor density is sensitive to the variation of pressure in the subcooled boiling flow, we also check the power relationship of ρg and the maximum bubble diameter. The pressure has a greater effect through changing the vapor density.

Dmaxf(Px,q1.0,ΔTsub0.5,G0.235, ρg1.0,Dh0.715)(12)

In the original research, φ is only considered to be a function of velocity itself. However, we find that an equation incorporating the Reynolds number is more accurate for calculating the maximum diameter of the bubble in the former investigation (Dong and Zhang, 2021). The hydraulic diameter in the Reynolds number can reflect the effect of the channel dimension on bubble growth, which is more suitable for use in the calculation than velocity is.

4 Validation and Discussion

In general, the key parameters of the ANN model include the number of neurons, number of hidden layers, activation function, and training algorithm. After a sensitivity analysis, we choose to use two hidden layers with eight neurons as the basic structure. The related R value can be increased to 0.9916, which is sufficiently accurate for the necessary calculations. In addition, the activation function and the training algorithm are also determined after comparing the accuracy of multiple combinations. The results show that the combination of logsig and tansig activation functions with the trainbr training algorithm gave the best performance, with a relative error of 13.50%. The trainbr algorithm, using Bayesian regularization back propagation, is a network training function that updates the weight and bias values according to Levenberg-Marquardt optimization. Trainbr can train any network, so long as its weight, net input, and transfer functions have derivative functions. It can minimize a linear combination of squared errors and weights and modify the linear combination so that at the end of training. the resulting network has good generalization qualities, even for different, small, or noisy datasets. Drawing on the above structure of the ANN model, more than 150 iterations of training are carried out for this prediction of maximum bubble diameter. The coefficient of determination R for nearly all the training sets is higher than 0.9, and 82% are higher than 0.95. This shows that the ANN model has a high confidence level, which increases the credibility of the calculated results.

4.1 Input Parameters in the Artificial Neural Networks Model

Appropriate input parameters are necessary structural elements in the ANN model. The parameters cannot be chosen arbitrarily and should reflect the effects of experimental conditions. For the prediction of maximum bubble maximum diameter in the subcooled boiling flow, experimental conditions, which include pressure, mass flow, hydraulic diameter, heat flux, local subcooling, and the physical and thermal properties of a heated surface should be paid more attention. Several dimensional parameters are chosen to test the relevance with bubble maximum diameter. The results are shown in Table 2. Multiple R and F refer to the significance level of relevance. It is concluded that dimensional dynamic viscosity μl/μv has little relevance to bubble maximum diameter, while the other parameters have a stronger or weaker relationship. However, some of the parameters have a direct connection with the others. ρl/ρv, Pe, Eo and S are chosen as the input parameters of ANN model. Considering the mechanism model and experimental conditions, subcooling ΔTsub and heat flux qw are added as a supplement.


TABLE 2. Relevance analysis of potential input parameters.

4.2 Validation of Artificial Neural Networks Model

After determining the structural elements of ANN model, experimental databases are used to train the ANN model. For all 366 sets of bubble maximum diameter, 70% of databases are randomly selected as training data, and 15% are used as the test and validation respectively. The results are shown in Table 3 and Figure 4; the average error of all the experimental databases is 13.54% which is much lower than for other mechanistic models. Furthermore, the ANN model increases the accuracy of calculations of large bubbles from Prodanovic’s database.


TABLE 3. Arithmetic-mean errors of different models for the databases.


FIGURE 4. Bubble maximum diameter predicted by the ANN model.

However, due to the inner black box features of ANNs, the trained ANN model can only be used for prediction, with the experimental conditions covered by the trained database. Once one of the experimental parameters exceeds the range used by training, the calculated maximum bubble diameter could show a partial large relative error.

4.3 Uncertainty Analysis of Experimental Conditions

Considering installation error and measurement error, the uncertainty analysis of the experimental conditions is carried out in this section. The errors include the measurement accuracy of measuring instruments and the uncertainty of measuring position, while the other environmental influences are not considered. The errors of experimental conditions and their influence to input parameters are shown in Table 4. Because the maximum coarseness of the common pressure gauge reaches level 4, the relative error is 4%, so the measurement error for pressure is set to ±5% in this paper. Pressure fluctuation would change the density, Prandtl number, and surface tension. Dimensional density, Pe, and Eo are affected. In general, the average heat flux of the experiment is calculated based on the heating power and the scale of heated surface. The local heat flux of subcooled flow boiling can be measured with a non-contacting heat flow meter. Taking the measuring accuracy of the equipment into account, the average relative error of heat flux is set to ±5%. The flowmeter has a better accuracy the other instruments of measurement, that is, no more than 2% for various types. In addition, there is no position error in the measurement of mass flux. On the contrary, the main contribution of measurement error for local subcooling is the position error. In the heat balance theory, the local subcooling is used for the calculation of bubble condensation. It is therefore important to measure the subcooled temperature of the position that the bubble generates through non-contacting measurement instruments. Considering the potential position error of this parameter, the measuring error of local subcooling is set to ±3%. Apart from these four parameters, the hydraulic diameter and thermal properties of heated surface are also given ±3% as a measurement error in this sensitivity analysis. However, the trend of data deviation induced by these two reasons should be the same for everything in the same experimental facility.


TABLE 4. The potential measuring error for different experimental conditions.

From the given measurement error and position error, new values of experimental conditions are chosen according to a uniform distribution in the value range. Then the input parameters are calculated and are used to form a series of new matrix. The maximum bubble diameters shown in Figure 5 are calculated by the trained ANN model based on the new databases of input parameters. As can be seen from the first four figures in Figure 6, only the fluctuations of pressure in four experimental conditions show appreciable effect on the bubble maximum diameter. The relative error of the total data set is enlarged from 13.54% to 19.04% when the pressure varies in a ±5% range. Therefore, pressure is considered to be the most sensitive parameter in the experimental conditions. This conclusion is consistent with the power relationship shown in Equation 10. It is also concluded that the ANN model has a good accuracy and robustness when facing the measurement error of experimental conditions. From the last two figures in Figure 6, the two experimental conditions related to experimental facility produce a large effect on the results, especially the hydraulic diameter. Furthermore, these two parameters remain the same through each experiment. Thus, it is necessary to determine the parameters related to the experimental section in a more accurate way before the experiment starts.


FIGURE 5. Results of the ANN model under the fluctuations of experimental conditions. (A) Pressure, (B) heat flux, (C) mass flux, (D) local subcooling, (E) hydraulic diameter, (F) thermal properties.


FIGURE 6. The distributions of bubble maximum diameter for different ranges of size. (A) Excluding the measurement error of P, (B) including the measurement error of P.

In the further analysis of pressure, the results are divided into four zones, according to the size of bubble maximum diameter. As can be seen in Figure 6, pressure has a larger influence on the zone where the bubble maximum diameter larger than 0.5 mm. The relative error increases about 12% while that of the other two zones varies only little. From a physical view, the larger bubble a larger amount of vapor inside. The fluctuation of pressure would influence larger bubble more through changing the vapor density. To increase the accuracy of the prediction, the correlation with pressure should be observed in both the experiments and in the mechanistic theoretical analysis.

4.4 New Correlation of Coefficients C and φ

The experimental condition pressure shows great sensitivity to the maximum bubble diameter, and its measurement should be prioritized. In the mechanistic model, we should also check the direct description of pressure, which is parameter C, used on the condensation part. In Ünal’s original paper, the correlation (5) of C proposed by Ünal is fitted from no more than 30 experimental datasets, as well as parameter φ. This may have the largest contribution to the error of heat balance models. This error is especially remarkable for the large maximum bubble value under low-pressure conditions.

Parameter C is only related to pressure, and parameter φ is only related to liquid velocity or Re in the original heat balance model (Ünal, 1976) and its modification (Dong and Zhang, 2021). In this paper, the product of C and φ is regarded as one element Cφ. Drawing on the conclusions of the sensitivity analysis of ANN model, further modifications are proposed for a mechanistic model that uses the input parameters ρl/ρv, Pe, and Eo instead of pressure and Re to form the new correlation of C and φ. After a statistical regression analysis, the new correlation of Cφ is shown below. It can be used directly in the coefficient B for Equation 3.


The results shown in Figure 7 are compared between the new correlation and original model (Dong and Zhang, 2021). The new correlation shows better performance for the bubble larger than 1 mm, in which the relative error is decreased from 51.39% to 33.19%. Other ranges of bubble size can also reach the same level or have greater accuracy.


FIGURE 7. Comparison of new correlation and original model for different bubble sizes.

Beyond the experimental data above, another calculation based on Kaiho et al.’s experiment (Kaiho et al., 2017) is carried out for an independent validation of the improved mechanistic model. The pressure range is 107–143 kPa, nearly atmospheric condition. The heat flux of the heated surface is around 175–617 kW/m2 while the mass flux is 159–700 kg/m2s. The subcooling of water is 10–30 K. The experimental results from Kaiho’s research include the arithmetic mean value and the volume average value of maximum bubble diameter. In this validation, average volume is chosen as the experimental data, which is closer to the assumptions of heat balance theory. The calculated results are shown in Figure 8. The total relative error is 14.43%, which shows good performance for the present model.


FIGURE 8. Independent validation of present model for Kaiho’s experiment.

5 Conclusion

Using ANNs, a data-driven model is proposed for the evaluation of bubble maximum diameter in subcooled boiling flow. After a basic sensitivity analysis is done on neuron number, two hidden layers with eight neurons each are used to develop the data-driven model. In addition, the activation function and training algorithm are screened out for the ANN model. Through the training using several experimental databases, the data-driven model shows good performance, with a relative error of around 14%. Sensitivity analysis is also proposed for the four experimental conditions and two structural conditions. The results identify the accuracy and robustness of the ANN model. It is also concluded that the measuring accuracy of pressure is of the most sensitivity on the bubble maximum diameter in the subcooled boiling flow under low-pressure conditions, especially for bubble sizes larger than 0.5 mm. A regression analysis of parameters C and φ, a new correlation is developed for the mechanistic model. This new model functions well for all the experimental databases and the large bubble datasets. Another independent validation also proves the accuracy of the improved mechanistic model. To sum up, the modified mechanistic model covers a wide range of subcooled boiling flow under low-pressure conditions. In the next step, additional attention will be paid to increasing the generalization performance of ANN model for larger experimental conditions.

Data Availability Statement

The original contributions presented in the study are included in the article/supplementary material, and further inquiries can be directed to the corresponding author.

Author Contributions

XD proposed the research algorithm for the data-driven model and wrote the original draft. HC used MATLAB to implement the research method. CL discussed the accuracy and its modification of ANN model. MY helped develop the structural analysis of ANN model. YY collected and analyzed the experimental databases. XH helped develop the modification of mechanistic model and the additional validation.


This research was funded by the Guang Dong Basic and Applied Basic Research Foundation (No. 2021A1515110922). Thanks to Shenzhen University and Nuclear Power Institute of China for the support.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The reviewer ZL declared a shared affiliation with the author(s) YY to the handling editor at the time of review.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.


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Keywords: bubble maximum diameter, data-driven model, subcooled boiling flow, artificial neural networks, sensitivity analysis

Citation: Dong X, Chen H, Li C, Yang M, Yu Y and Huang X (2022) An Evaluation of the Data-Driven Model for Bubble Maximum Diameter in Subcooled Boiling Flow Using Artificial Neural Networks. Front. Energy Res. 10:903464. doi: 10.3389/fenrg.2022.903464

Received: 24 March 2022; Accepted: 06 June 2022;
Published: 15 August 2022.

Edited by:

Jun Wang, University of Wisconsin-Madison, United States

Reviewed by:

Luteng Zhang, Chongqing University, China
Zhongchun Li, Nuclear Power Institute of China (NPIC), China
Dongxu Ji, The Chinese University of Hong Kong, China

Copyright © 2022 Dong, Chen, Li, Yang, Yu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Xiaomeng Dong,; Yang Yu,