This article is a correction to:
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages
Marco Orecchioni
Yanal Ghosheh1
Akula Bala Pramod
Klaus Ley- 1Division of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, United States
- 2Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States
A Corrigendum on
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages
by Orecchioni, M., Ghosheh, Y., Pramod, A. B., and Ley, K. (2019). Front. Immunol. 10:1084. doi: 10.3389/fimmu.2019.01084
In the original article, there was a mistake in Figure 3 as published. Three gene names were misspelled in the previous version. In Figure 3A, M1(=LPS+) panel, the correct gene name for EIFE3 is EIF4E3. In Figure 3B, alternatively activated (IL-4) panel, the correct gene name for WRD4 is WDR4. Also in Figure 3B, the correct gene name for POLRR3K is POLR3K. The corrected Figure 3 appears below.
Additionally, in the original article, there was a mistake in the legend for Figure 3 as published. “M1(=LPS+)” was written as “M1(LPS+)”, and “M2(=LPS−)” was written as “M2(LPS−)”. The correct legend for Figure 3 appears below.
FIGURE 3
Figure 3. In vivo macrophage signatures predict survival in osteosarcoma cancer biopsy transcriptomes. Survival data for human osteosarcoma cancer biopsies (GSE21257) were analyzed for the impact of M1(=LPS+) and classically activated (LPS+IFN-γ) (A) and M2(=LPS−) and alternatively activated (IL-4) (B) gene expression signatures in the tumor biopsy transcriptome. Kaplan–Meier curves were plotted using ProggeneV2, divided by the median of the mean expression of a tumor-specific gene list (in boxes). Hazard ratio (HR, cox proportional hazard analysis) and significance (log rank P-value) are shown. Red, green curves indicate high, low expression of the respective signature genes. The two vertical black lines indicates 3 and 5 years, respectively.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Keywords: macrophage, innate immunity, M1, M2, cancer
Citation: Orecchioni M, Ghosheh Y, Pramod AB and Ley K (2020) Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages. Front. Immunol. 11:234. doi: 10.3389/fimmu.2020.00234
Received: 28 January 2020; Accepted: 28 January 2020;
Published: 25 February 2020.
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
Copyright © 2020 Orecchioni, Ghosheh, Pramod and Ley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Klaus Ley, klaus@lji.org
†Present address: Klaus Ley, Division of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, United States