This editorial, emerging from the Frontiers of Immunology Research Topic of the same name, delves into the central theme of immune aspects shaping the health dynamics of aquatic organisms. It synthesizes a series of scholarly investigations within the Research Topic, presenting a comprehensive exploration of immunological nuances in aquatic ecosystems. The curated Research Topic showcases diverse research, from examinations of marine model organisms such as Exaiptasia pallida to insights into epigenetic adaptations in invertebrates and mutant fish screening. This scholarly synthesis attests to intellectual diversity and methodological rigor in aquatic immunology, enhancing the comprehension of the intersection between immune responses and the health of aquatic organisms.
Billaud et al. examined the repercussions of climate change on marine ecosystems. Using Exaiptasia pallida as a model organism, the authors meticulously scrutinize the immunological responses to heightened temperatures and Vibrio parahaemolyticus infections. Observations on morphological changes and heat-shock protein expression underscore the integral role of immune responses in safeguarding the well-being of aquatic organisms. Identifying AF10 cells as potential phagocytes contributes to the nuanced understanding of immune complexities in the aquatic milieu.
Zhao et al. extend the academic narrative by elucidating immune adaptations in arthropods and mollusks. Their exploration of epigenetic modifications facilitating the diversification of immune proteins underscores an evolutionary strategy. Introducing trained immunity puts forward a dynamic dimension where immunological memories endure and transmit across generations. However, the extant limitations in comprehending pathogen-host interactions establish an academic imperative for further elucidation of invertebrate immunity dynamics.
Zhang et al. complement the discourse by examining the Receptor Interacting Protein 2 (RIP2) in the context of viral infections within the orange-spotted grouper. The structural elucidation of EcRIP2 and its purported role in suppressing SGIV replication forms the basis of their analysis. The articulated need for a more comprehensive exploration of downstream signaling pathways brings in a scholarly recognition of the intricate facets governing immune responses in fish viral infections.
Sakaguchi et al. contributed with investigating the symbiotic relationship between host immune systems and intestinal microorganisms in the medaka fish model. The CRISPR-mediated manipulation of interleukin 2 receptor subunit gamma (il2rg) is a focal point, revealing alterations in operational taxonomic units and emphasizing the delicate equilibrium between host immunity and microbial communities. The establishment of germ-free conditions augments the depth of inquiry into the role of microbiota in intestinal health and immune system maturation. Criticisms of methodological limitations acknowledge extant challenges within the academic discourse.
In summary, this Research Topic represents a scholarly endeavor unraveling immune dynamics in aquatic organisms. Each manuscript significantly contributes to our collective understanding, emphasizing the critical importance of adopting an immune perspective. The effectiveness of employing diverse animal models to elucidate specific immune mechanisms governing health, both in vertebrates and invertebrates, is highlighted, aligning with previous suggestions (1). Navigating the intricate landscape of aquatic immunology, these contributions enrich our scientific knowledge and delineate pathways for future research endeavors. They underscore the imperative of fortifying the health and resilience of aquatic ecosystems through a comprehensive understanding and appreciation of the nuanced complexities inherent in immune responses.
Statements
Author contributions
AF: Conceptualization, Writing – original draft. LW: Conceptualization, Writing – original draft. SM: Conceptualization, Writing – original draft. JG-V: Conceptualization, Visualization, Writing – review & editing, Supervision.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Publisher’s note
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References
1
Galindo-VillegasJ. The zebrafish disease and drug screening model: A strong ally against covid-19. Front Pharmacol (2020) 11:680. doi: 10.3389/fphar.2020.00680
Summary
Keywords
AF10 cells, arthropods, CRISPR, crustacea, germ-free, medaka, receptor interacting 9 protein 2, trained immunity
Citation
Figueras A, Wang L, MacKenzie S and Galindo-Villegas J (2024) Editorial: Exploring the health of aquatic organisms through an immune viewpoint. Front. Immunol. 14:1356400. doi: 10.3389/fimmu.2023.1356400
Received
15 December 2023
Accepted
22 December 2023
Published
09 January 2024
Volume
14 - 2023
Edited and reviewed by
Jun Li, Lake Superior State University, United States
Updates
Copyright
© 2024 Figueras, Wang, MacKenzie and Galindo-Villegas.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jorge Galindo-Villegas, Jorge.galindo-villegas@nord.no
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.