In the original article, there was a mistake in Figure 8B as published. In the left bottom panel of Figure 8B, the image representing hippocampal CA3 of sham controls was from an animal with mTBI. The error was introduced while making figures. The corrected Figure 8 appears below showing images from a different experiment that confirmed the original findings, with additional quantitative analysis showing the difference between sham and mTBI animals.
Figure 8
Prominent p-Tau immunoreactivity after repetitive mTBI. Wildtype C57BL/6J mice (male, 3 months of age) received three mild impacts (mTBI) or underwent sham procedures (sham). Mice were sacrificed 6 months later and brains were fixed for immunohistochemistry with an antibody against phospho-Tau (p-Tau, AT8). (A) Schematic diagrams of brain sections adapted from the mouse brain atlas (26) represent the approximate antero-posterior levels (to Bregma) where consistent neuropathological alterations were observed in mTBI (bottom) compared with sham (top). Note less p-Tau immunopositive cells in the contralateral side. The arrows in the bottom panel show approximate point of impact. (B) Representative images obtained from ipsilateral side of mTBI showing p-Tau immunoreactive cells in the corpus callosum, amygdala, hippocampus, and septal nuclei. Notice the weak or absence of p-Tau immunoreactivity in sham group. Scale bar = 20 μm. p-Tau immunoreactivity of ipsilateral side (bottom panels) was quantified as numbers of p-Tau+ cells (left panel) or percentage of area occupied (right panel) from different brain regions. Mean ± SEM. *P <0.05; **P <0.01, by t-test.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Summary
Keywords
mild traumatic brain injury, long-term, neurobehavior, bioluminescence, astrogliosis
Citation
Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS and Wyss-Coray T (2022) Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury. Front. Neurol. 13:730576. doi: 10.3389/fneur.2022.730576
Received
25 June 2021
Accepted
25 April 2022
Published
29 June 2022
Volume
13 - 2022
Edited and reviewed by
Mårten Risling, Karolinska Institutet (KI), Sweden
Updates
Copyright
© 2022 Luo, Nguyen, Villeda, Zhang, Ding, Lindsey, Bieri, Castellano, Beaupre and Wyss-Coray.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jian Luo jianl@stanford.eduTony Wyss-Coray twc@stanford.edu
†Present address: Saul Villeda, Department of Anatomy, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA
This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.