At the interface of lifestyle, behavior and circadian rhythms: Metabolic implications
- 1Rutgers University, The State University of New Jersey, United States
- 2Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, United States
- 3Biomedical Engineering, Rutgers University, The State University of New Jersey, United States
Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by stressors, lifestyle and behavioral choices such as work schedules, eating patterns and jetlag, including social, seriously impact and impair metabolism. Metabolic dysfunction due to chronic misalignment of the organism’s endogenous rhythms and environmental cues is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks, and how human behavioral changes imposed by social and occupational demands affect the known components of the network integrating peripheral clocks and metabolism. We also discuss possible factors that contribute to inter-individual variability in response to circadian changes in the context of metabolic function.
Keywords: metabolic syndrome, circadian rhythms, Chronodisruption, shift work, Metabolism
Received: 26 Apr 2019;
Accepted: 06 Aug 2019.
Copyright: © 2019 Bae, Fang, Rustgi, Zarbl and Androulakis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Ioannis P. Androulakis, Rutgers University, The State University of New Jersey, Biomedical Engineering, New Brunswick, 08854, new Jersey, United States, email@example.com