%A Ascierto,Maria Libera %A Melero,Ignacio %A Ascierto,Paolo Antonio %D 2015 %J Frontiers in Oncology %C %F %G English %K Immunotherapy,Melanoma,Adoptive T Cell Therapy,immunomodulatory antibodies,Vaccination,combination therapy %Q %R 10.3389/fonc.2015.00152 %W %L %M %P %7 %8 2015-July-13 %9 Review %+ Paolo Antonio Ascierto,Unit of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori Fondazione “G. Pascale”,Italy,paolo.ascierto@gmail.com %# %! The success of immunoltherapy in melanoma %* %< %T Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy %U https://www.frontiersin.org/articles/10.3389/fonc.2015.00152 %V 5 %0 JOURNAL ARTICLE %@ 2234-943X %X After Coley’s observation in 1891 of tumor regression in a patient who developed a postoperative infection, the field of immunotherapy is finally reborn. Avoiding immune destruction is now considered a hallmark of cancer, and the immunotherapy arena has exploded with the recent advances demonstrating an improvement in survival and a durability of response in patients with different cancer types, which translates into improved overall survival benefit. Here, we provide an overview of the main immune-oncology treatment strategies that, either alone or in combination, are undergoing clinical development. Namely, we will refer to those immunotherapeutic strategies that include adoptive transfer of ex vivo activated T cells, immunomodulatory monoclonal antibodies, and cancer vaccines. Our major focus will be to describe these approaches in melanoma, a cancer type transformed by immunotherapy into a potentially curable disease.