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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Oncol. | doi: 10.3389/fonc.2019.00075

The Possible Role of Helicobacter pylori In Gastric Cancer and its Management.

 Khalid O. Alfarouk1*, Adil H. Bashir2, Ahmed N. Aljarbou3, 4,  AbdelRahman M. Ramadan5, Abdel K. Muddathir2,  Sari T. AlHoufie4, 5, Abdelhamid Hifny6,  Gamal O. Elhassan7, Muntaser E. Ibrahim2,  Saad S. Alqahtani8,  Shakir D. AlSharari9, Claudiu T. Supuran10,  Cyril Rauch11, Rosa A. Cardone12,  Stephan J. Reshkin12,  Stefano Fais13 and  Salvador Harguindey14
  • 1Alfarouk Biomedical Research LLC, United States
  • 2Institute of Endemic Diseases, University of Khartoum, Sudan
  • 3College of Pharmacy, Qassim University, Saudi Arabia
  • 4Al-Ghad International College for Applied Medical Sciences, Saudi Arabia
  • 5Departments of Basic and Clinical Dental Sciences and Preventive Dental Sciences, College of Dentistry, Taibah University, Saudi Arabia
  • 6Faculty of Medicine, Al-Azhar University, Egypt
  • 7Faculty of Pharmacy, Omdurman Islamic University, Sudan
  • 8Faculty of Pharmacy, Jazan University, Saudi Arabia
  • 9college of pharmacy, King Saud University, Saudi Arabia
  • 10Neurofarba Department, Università degli Studi di Firenze, Italy
  • 11University of Nottingham, United Kingdom
  • 12Department of Biosciences, Biotechnology and Biopharmaceutics, Università degli Studi di Bari, Italy
  • 13Istituto Superiore di Sanità (ISS), Italy
  • 14Institute of Clinical Biology and Metabolism, Spain

Helicobacter pylori (HP) is a facultative anaerobic bacterium. HP is a normal flora having immunomodulating
properties. This bacterium is an example of a microorganism inducing gastric cancer. Its
carcinogenicity depends on bacteria-host related factors. The proper understanding of the biology of HP
inducing gastric cancer offers the potential strategy in the managing of HP rather than eradicating it. In
this article, we try to summarize the biology of HP-induced gastric cancer and discuss the current
pharmacological approach to treat and prevent its carcinogenicity.

Keywords: Helicobacter pyloni, gastric cancer, pH, Inflammation, Pharmacology

Received: 03 Sep 2018; Accepted: 28 Jan 2019.

Edited by:

Tiziana Venesio, Institute for Cancer Research and Treatment (IRCC), Italy

Reviewed by:

Amit Gupta, All India Institute of Medical Sciences, Rishikesh, India
Cristiana Laudi, Fondazione del Piemonte per l'Oncologia, Istituto di Candiolo (IRCCS), Italy  

Copyright: © 2019 Alfarouk, Bashir, Aljarbou, Ramadan, Muddathir, AlHoufie, Hifny, Elhassan, Ibrahim, Alqahtani, AlSharari, Supuran, Rauch, Cardone, Reshkin, Fais and Harguindey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Khalid O. Alfarouk, Alfarouk Biomedical Research LLC, Temple Terrace, Florida, United States,