In the published article, there was an error in Figures 2B and 3D as published. Two representative images of colony formation were unintentionally inserted twice during the figure assembly for the manuscript preparation. The images of HepG2 cells shown in Figure 3D were inserted by mistake in Figure 2B (panel HepG2 cells). The images of HUH7 shown in Figure 2B were inserted by mistake in Figure 3D (panel SNU398 cells). The corrected Figure 2B and Figure 3D and their caption appear below.
Figure 2
Abemaciclib and lenvatinib combination exerts additive anti-proliferative effects in HCC cells and inhibits colony formation more strongly than single agents. (A) Cells were treated with A, L or the combination. The growth medium with drugs was refreshed every 3 days. After 6 days, cell proliferation was assessed by CV assay. Combination indexes were calculated with Calcusyn software. (B) HUH7, SNU398, and HepG2 cells were treated with A or L at their corresponding IC50 values alone or in combination. After 6 days, colony formation was assessed by CV assay. Representative images of crystal violet staining of colonies are shown. ***p<0.001 vs C, ###p<0.001 vs A; §§p< 0.01, §§§p<0.001 vs L. Data in A are representative of three independent experiments. Data in B are mean values ± SD of three independent experiments.
Figure 3
Ribociclib and lenvatinib combination exerts additive anti-proliferative effects in HCC cells and inhibits colony formation more strongly than single agents. (A) After 24h from seeding, HUH7, SNU398, and HepG2 cells were treated with increasing concentrations of ribociclib (R) for 6 days. Cells proliferation was evaluated by CV assay and the IC50 values were calculated using GraphPad Prism 6.00 software. (B) HCC cells were untreated (C) or treated with 1 μM R for 24h. The cells were lysed and the expression of the indicated proteins was evaluated by Western blot analysis. (C) Cells were treated with R, L or the combination. The growth medium with drugs was refreshed every 3 days. After 6 days, cell proliferation was assessed by CV assay. Combination indexes were calculated with Calcusyn software. (D) HUH7, SNU398, and HepG2 cells were treated with R or L at their corresponding IC50 values alone or in combination. After 6 days, colony formation was assessed by CV assay. Representative images of crystal violet staining of colonies are shown. ***p<0.001 vs C; #p<0.05, ##p<0.01 ###p<0.001 vs R; §p< 0.05, §§§p<0.001 vs L. Data in A are mean values ± SD of three independent experiments. Data in B-C are representative of two independent experiments. Data in D are mean values ± SD of two independent experiments.
The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Publisher’s note
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Summary
Keywords
hepatocarcinoma (HCC), CDK4/6 inhibition, abemaciclib, lenvatinib, senescence
Citation
Digiacomo G, Fumarola C, La Monica S, Bonelli M, Cavazzoni A, Galetti M, Terenziani R, Eltayeb K, Volta F, Zoppi S, Bertolini P, Missale G, Alfieri R and Petronini PG (2024) Corrigendum: CDK4/6 inhibitors improve the anti-tumor efficacy of lenvatinib in hepatocarcinoma cells. Front. Oncol. 14:1532291. doi: 10.3389/fonc.2024.1532291
Received
21 November 2024
Accepted
26 November 2024
Published
06 December 2024
Volume
14 - 2024
Edited and reviewed by
Tong-Chuan He, University of Chicago Medicine, United States
Updates
Copyright
© 2024 Digiacomo, Fumarola, La Monica, Bonelli, Cavazzoni, Galetti, Terenziani, Eltayeb, Volta, Zoppi, Bertolini, Missale, Alfieri and Petronini.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Silvia La Monica, silvia.lamonica@unipr.it; Andrea Cavazzoni, andrea.cavazzoni@unipr.it
†These authors have contributed equally to this work
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.