Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature
Chiara Iacusso
Alessandro Boscarelli
Fabio Fusaro
Pietro Bagolan
Francesco Morini- Department of Medical and Surgical Neonatology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Introduction: Neonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors.
Materials and methods: Retrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy. All articles referring to NGP published between 2005 and 2017 were retrieved. Variables considered: prematurity (<37 weeks gestation), birth weight (BW), Apgar score, prenatal complications, age at diagnosis, bag ventilation, pathogenetic events, site of perforation, treatment of perforation, sepsis, and outcome. Mann–Whitney or Fisher’s test were used as appropriate. Results are median (range) or prevalence.
Results: Between 2009 and 2016 we treated 8 consecutive patients for NGP and 199 further cases were retrieved from the systematic review (total of 207 patients). Overall survival was 73%. Most frequently reported pathogenesis: iatrogenic (20 patients), hypoxic/ischemic or infection stress (13 patients), duodenal/jejunal obstruction (11 patients), drugs (11 patients), esophageal atresia (10 patients). 60% patients had only primary repair of the perforation as gastric surgery. Sepsis developed in 56 patients (34%).
Conclusion: Although the pathogenesis of NGP is pleomorphic, prematurity and low BWs are frequent in these patients. Reviewing our experience and the available literature, none of the variables considered, but sepsis was associated with mortality.
Introduction
Neonatal gastric perforation (NGP) is an uncommon life-threatening entity in newborns, potentially challenging for the treating physicians. The reported incidence is 1:5,000 live births and NGP represents 7% of all gastrointestinal perforations in the newborn (1). The first reported case of spontaneous NGP was in 1825 by Siebold (2). Since then, the number of neonatal gastrointestinal perforation (including NGP) is in progressive rise, may be due to the increasing number of very-low birth weight and premature infants, while the mortality related to NGP has dropped by about tenfold, probably due to the improvement of the quality of the neonatal intensive care (3). Despite the increase in prevalence, NGP remains a relatively rare condition, with mainly case reports or small series reported. As a consequence, several aspects of NGP are still unclear, ranging from the etiology to its best treatment.
The aim of this study was to report our own experience with NGP and review the available literature on the issue, in an attempt to better characterize NGP, describe associated factors and treatments proposed, and define prognostic aspects.
Materials and Methods
A retrospective analysis of all consecutive patients with NGP admitted to our third level pediatric hospital between January 2009 and December 2017 was carried out. The time span was chosen to have available electronic records for all patients. Variables considered included: prematurity (<37 weeks gestation), birth weight (BW), Apgar score at 1′ and 5′, prenatal maternal or fetal complications/treatments, fetal radiological signs, age at diagnosis, possible pathogenetic events, site of perforation, treatment of perforation, associated sepsis, and outcome in terms of mortality.
In addition, a systematic review of the literature was performed following PRISMA guidelines by two authors separately (CI and AB), searching the MEDLINE and SCOPUS electronic databases using the MeSH terms “neonate” and “gastric perforation.” In an attempt to include as many reported patients as possible, all full-text articles, including case reports and letters to the editor were retrieved and analyzed, provided they reported data on neonates with gastric perforation confirmed at surgery. Relevant studies were also searched in the reference lists of retrieved studies. We applied a date limit in order to include in the study only recent articles (published between 2005 and 2017) and written in English language. As a consequence, no conflicts had to be resolved. The variables extracted were the same as those for our retrospective series.
Statistical analysis was performed using Mann–Whitney test for continuous variables and Fisher’s exact test for categorical variables, results are reported as median (range) or prevalence, and p value < 0.05 was considered as statistically significant.
This study was approved by the Institutional Review Board from our institution (201502P003480).
Results
Between January 2009 and December 2017, we treated eight consecutive patients for NGP. All were transferred from referring hospitals once the perforation was diagnosed. None had prenatal findings that suggested gastric perforation. In three cases prenatal ultrasound showed polyhydramnios. Three patients were preterm, two late preterm (37 weeks gestation) and three were born at term. The mothers of all preterm patients received steroids, 2 weeks before delivery in two (neonates born at 34 weeks gestation), and shortly before delivery in the third (neonate born at 32 weeks gestation). Mean BW was 2500 g (range 1,400–3200 g). The median age at presentation was 3 days of life; only one patient had a late onset (day 27) of gastric perforation. This case followed gap measurement for esophageal atresia (OA) using a Hegar dilator inserted through the gastrostomy to identify the length of the lower esophageal pouch (4). Four patients received mechanical ventilation support before gastric perforation occurred. Three patients had been fed before the perforation. The perforation was considered spontaneous in two cases (one detected shortly after birth) and secondary to trauma in the remaining six patients: five nasogastric tube decubitus and/or bag ventilation, one hegar dilator trauma. Associated malformations were OA with tracheo-esophageal fistula in two cases, duodenal web in one, and intestinal malrotation in one. All patients underwent open gastrorrhaphy, associated with a gastrostomy in three. Further management included correction of malrotation (Ladd’s procedure) and simple duodenotomy with duodenal web excision in one patient each. The infants with OA underwent closure of tracheo-esophageal fistula and direct esophageal anastomosis. Three patients developed a severe sepsis, treated with intravenous broad-spectrum antibiotics and antimycotic drugs. None of the patients of our series died.
The systematic review of the literature allowed to identify 51 articles (Figure 1) describing 200 further cases of NGP (1–3, 5–26, 30–52, 55–57). One patient was excluded from this study because managed conservatively and the perforation could not be confirmed, leaving 199 patients for the analysis (Table 1).
Figure 1. PRISMA 2009 flow diagram of systematic review of the literature (54).
Table 1. Literature review.
Prematurity was reported in 49% of patients. The pathogenesis was reported in 168 patients (including our series) and considered idiopathic in 79 (47%). The most frequent causes in non-idiopathic cases were: traumatic procedure (mechanical ventilation, esophageal intubation, NG tube insertion), ischemic insult, antenatal drugs (e.g., NSAID), or secondary to associated anomalies (Table 2).
Table 2. Causes of neonatal gastric perforation in non-idiopathic cases retrieved from the Literature and present series.
The most common site of perforation was the greater curvature (50%). Overall survival rate was 73%. Considering a total number of 207 patients (including our series), data on factors associated with mortality are available for 152 patients (Table 3). Survivors and non-survivors (NS) were similar in terms of prevalence of preterm birth, BW, Apgar score, prenatal manifestations, number of outborn patients, associated anomalies, and age at diagnosis. Only the prevalence of sepsis was statistically higher in NS (p < 0.0001).
Table 3. Clinical characteristics.
Discussion
Neonatal gastric perforation is an uncommon life-threatening entity in neonates, with several ill-defined aspects (58). This is the first study performing a systematic review of the recent literature to try to define pathogenetic and prognostic factors in neonates with gastric perforation.
In this study, we found that prematurity or low BW is frequently associated with the development of NGP. If cases with obvious anatomical predisposing factors (such as gastric outlet obstruction) or traumatic events are excluded, the etiology of NGP is still controversial, but prematurity, low birth weight (LBW), severe infections, and hypoxia are considered as contributing factors (3, 26). In this study, prematurity was reported in a substantial proportion on patients with NGP. Accordingly, in 2008 Lin and colleagues reported 15 cases and reviewed the literature, finding higher incidence of NGP among LBW babies (52%) in particular, in extremely LBW neonates, and suggested that premature infants are more prone to develop a spontaneous gastric perforation due to the immaturity of the gastric tissue (2). Similarly, in the survey from Sato et al. (45), 11 out of 42 neonates with gastric perforation were ELWB. Prematurity may predispose to NGP through several factors, including defects of the gastric muscle wall (especially in immature tissues of preterm babies), lack of intestinal pacemaker cells, and lack of C-KIT mast cell (27). Gastric smooth muscle cells (SMC) share with the interstitial cells of Cajal (ICC), the undifferentiated precursor stage. The expression of C-KIT, a tyrosine kinase receptor determines the development of ICC or SMC. The ICC plays an important role for the coordination of gastric motility, inducing slow rhythmic contractions of the gastrointestinal tract and neurotransmission. A condition of decreased ICC, as in premature infants, may determine a hypomobility of the gastrointestinal tract and predispose to spontaneous NGP (2). Accordingly, in 7 neonates with gastric perforation, Ohshiro et al. (53) found no ICC in the stomach of 3 patients and reduced ICC in the other 4, as compared to 10 control neonates. Incoordination and immaturity of esophagogastric motility, typical of premature neonates, are suggested as a possible mechanism causing increased intragastric pressure, thereby predisposing to gastric rupture (59). However, when gastric rupture occurs solely from overdistension, the rupture is usually along the lesser curvature (60). In present series, and collected patients from the systematic review of the literature, the perforation was most commonly in the greater curvature, suggesting that also other factors may play a role in gastric rupture in these patients. In premature infants, the gastric wall may have an intrinsic fragility. As a consequence, relatively minor traumatic events (such as the nasogastric tube decubitus and/or bag mask ventilation, hard crying or neonatal swallowing incoordination) or abnormally high intragastric pressure may bring about a local gastric wall disruption and perforation. In addition, in the gastrointestinal system of the premature infant, circulatory regulation may not be fully developed, possibly causing a reduced blood flow during hypoxic events or non-steroid anti-inflammatory drugs (NSAID) treatments. It is possible that the immature vascular bed may participate in the development of NGP, as supported by the association of NGP with necrotizing enterocolitis or NSAID administration (6, 61). Finally, neonates, particularly preterm ones, may present increased susceptibility to infectious complications, both bacterial and fungal, that have been associated with the development of gastric perforation (9, 18).
Anatomical anomalies leading to gastric outlet obstruction may predispose to NGP both in term and preterm neonates. One of our patients who developed NGP had associated duodenal web. He was also preterm (34 weeks gestation) and it is not possible to define without uncertainty whether the prematurity was the major pathogenetic element or if the interplay between gastric outlet obstruction and prematurity contributed to the perforation. However, the gastric outlet obstruction may have played a role in the development of NGP through an abnormal increase of intragastric pressure. In 2008, Esposito and colleagues reported a case of antenatal gastric perforation associated with Bochdaleck diaphragmatic hernia, presenting at birth as pneumothorax and perforative peritonitis (10). Other extremely rare condition, such as Carmi Syndrome can be associated with NGP. The presence of congenital pyloric atresia associated with epidermolysis bullosa, may predispose to high intragastric pressure, representing a risk factor for NGP (11).
Clinical presentation of NGP is usually characterized by acute abdominal distention often associated with sepsis and respiratory failure. Although up to 70% mortality rate has been reported in NGP, the advance of the technology for respiratory and hemodynamic support improved the survival rate of patients with NGP during past years (27). In our study, sepsis was the only variable significantly associated with mortality. Therefore, in a neonate with suspected NGP, signs of hypovolemic or septic shock must be actively checked, as timely treatment of this complication appears to be the single most important factor influencing survival. Although conservative management of neonatal pneumoperitoneum with a peritoneal drain has been proposed, especially in critically unstable patients, when the patient is stabilized, surgery is the ideal treatment in this uncommon disorder, also to contribute to the management of septic shock (5, 28, 29). Surgical treatment may be limited to necrotic tissue excision and gastrorrhaphy, if the abdominal cavity has only limited or no flogistic changes. In case of important inflammation, an associated gastrostomy should be considered. Rarely partial gastrectomy was performed in case of massive gastric disruption. In addition, the underlying anatomical cause must be recognized and treated, if present.
This study has some limitations. First, the rarity of the condition itself. To try to overcome this limitation and to increase the study population, we have performed a systematic review of the literature. We have empirically limited to 2005, the date of the review to include only the series/cases treated more recently, to avoid potential biases related to treatment changes on mortality rate. The inclusion of all types of studies, including case reports and editorials provided they described patients, without preclusions related to the country of origin, may be a source of heterogeneity, and introduce some biases related to treatment availabilities. However, the fact that prematurity or low BW was not associated with the outcome in terms of mortality suggests that studies were not that heterogeneous in terms of treatment availabilities.
Conclusion
In conclusion, gastric perforation is an uncommon, but life-threatening condition of the neonates. In present series and systematic review of the literature, the only factor affecting survival was the development of sepsis, probably related to prompt diagnosis and surgical treatment and high quality of pre- and post-operative care. In the past 10 years, the overall survival rate has drastically improved, from less than 25% to over 50%, probably thanks to the progress in neonatal intensive care procedures.
Ethics Statement
This study was approved by the Institutional Review Board from our institution (201502P003480).
Author Contributions
FM, FF, and CI conceived and coordinated the study. CI and AB collected data. CI and FM analyzed data and wrote the paper. FM and PB reviewed the results and approved the final version of the manuscript.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1. Aydin M, Deveci U, Taskin E, Bakal U, Kilic M. Percutaneous peritoneal drainage in isolated neonatal gastric perforation. World J Gastroenterol (2015) 21:12987–8. doi:10.3748/wjg.v21.i45.12987
2. Lin CM, Lee HC, Kao HA, Hung HY, Hsu CH, Yeung CY, et al. Neonatal gastric perforation: report of 15 cases and review of the literature. Pediatr Neonatol (2008) 49:65–70. doi:10.1016/S1875-9572(08)60015-7
3. Terui K, Iwai J, Yamada S, Takenouchi A, Nakata M, Komatsu S, et al. Etiology of neonatal gastric perforation: a review of 20 years’ experience. Pediatr Surg Int (2012) 28:9–14. doi:10.1007/s00383-011-3003-4
4. Morini F, Bagolan P. Gap measurement in patients with esophageal atresia: not a trivial matter. J Pediatr Surg (2015) 50:218. doi:10.1016/j.jpedsurg.2014.09.082
5. Yang CY, Lien R, Fu RH, Chu SM, Hsu JF, Lai JY, et al. Prognostic factors and concomitant anomalies in neonatal gastric perforation. J Pediatr Surg (2015) 50:1278–82. doi:10.1016/j.jpedsurg.2015.04.007
6. Kawase Y, Ishii T, Arai H, Uga N. Gastrointestinal perforation in very low-birthweight infants. Pediatr Int (2006) 48:599–603. doi:10.1111/j.1442-200X.2006.02282.x
7. Gluer S, Schmidt AI, Jesch NK, Ure BM. Laparoscopic repair of neonatal gastric perforation. J Pediatr Surg (2006) 41:e57–8. doi:10.1016/j.jpedsurg.2005.10.061
8. Ebenezer K, Bose A, Carl S. Neonatal gastric perforation following inadvertent connection of oxygen to the nasogastric feeding tube. Arch Dis Child Fetal Neonatal Ed (2007) 92(5):F407. doi:10.1136/adc.2006.112367
9. Korhonen P, Helminen M, Iber T, Abram A, Tammela O. An unexpected cause of gastric perforation in a term-born neonate. Diagnosis: neonatal gastric perforation due to fungal infection. Acta Paediatr (2007) 96:600–1. doi:10.1111/j.1651-2227.2006.00227.x
10. Esposito C, Settimi A, Centonze A, Savanelli A, Ascione G, De Marco M, et al. Bochdaleck diaphragmatic hernia, complicated by an antenatal gastric perforation, presenting as a pneumothorax and a perforative peritonitis. Pediatr Surg Int (2008) 24:365–9. doi:10.1007/s00383-007-2000-0
11. Joshi M, Krishnan L, Kuruvila S. Large gastric perforation in carmi syndrome: a morbid complication in a rare association. J Neonatal Surg (2012) 1:57.
12. Khan YA, Akhtar J. Pneumoscrotum: a rare presentation of gastric perforation in a neonate. APSP J Case Rep (2010) 1:15.
13. Khan YA, Zamir N. Missed congenital pyloric atresia with gastric perforation in a neonate. J Neonatal Surg (2012) 1:32.
14. Ghribi A, Krichene I, Fekih Hassen A, Mekki M, Belghith M, Nouri A. Gastric perforation in the newborn. Tunis Med (2013) 91:464–7.
15. Jactel SN, Abramowsky CR, Schniederjan M, Durham MM, Ricketts RR, Clifton MS, et al. Noniatrogenic neonatal gastric perforation: the role of interstitial cells of Cajal. Fetal Pediatr Pathol (2013) 32:422–8. doi:10.3109/15513815.2013.799248
16. Jiang Y, Sun BP, Shi LP. Gastric perforation associated with congenital diaphragmatic hernia in a neonate. Iran J Pediatr (2013) 23:712–4.
17. Bos ME, Wijnen RM, de Blaauw I. Gastric pneumatosis and rupture caused by lactobezoar. Pediatr Int (2013) 55:757–60. doi:10.1111/ped.12164
18. Mathur NB, Gupta A. Neonatal zygomycosis with gastric perforation. Indian Pediatr (2013) 50:699–701. doi:10.1007/s13312-013-0176-z
19. Mahgoub L, Lilic N, Evans M, Joynt C. Stomach infarction in an ex-premature infant. BMJ Case Rep (2014). doi:10.1136/bcr-2013-202814
20. Hassan RAA, Ridzuan AS, Guan TP, Sayed A. Postoperative spontaneous gastric perforation in a ruptured exomphalos: a case report. J Neonatal Surg (2016) 5(2):19.
21. Woo J, Eusterbrock T, Kim S. Intrauterine gastric perforation. Pediatr Surg Int (2006) 22:829–31. doi:10.1007/s00383-006-1713-9
22. Gupta G, Kumar S, Gupta S, Golhar KB, Deshpande S. Neonatal gastric perforations: are they really spontaneous? Indian J Surg (2014) 76:319–20. doi:10.1007/s12262-013-0980-7
23. Byun J, Kim HY, Noh SY, Kim SH, Jung SE, Lee SC, et al. Neonatal gastric perforation: a single center experience. World J Gastrointest Surg (2014) 6:151–5. doi:10.4240/wjgs.v6.i8.151
24. Lee DK, Shim SY, Cho SJ, Park EA, Lee SW. Comparison of gastric and other bowel perforations in preterm infants: a review of 20 years’ experience in a single institution. Korean J Pediatr (2015) 58:288–93. doi:10.3345/kjp.2015.58.8.288
25. Kshirsagar AY, Vasisth GO, Ahire MD, Kanojiya RK, Sulhyan SR. Acute spontaneous gastric perforation in neonates: a report of three cases. Afr J Paediatr Surg (2011) 8:79–81. doi:10.4103/0189-6725.78935
26. Duran R, Inan M, Vatansever U, Aladağ N, Acunaş B. Etiology of neonatal gastric perforations: review of 10 years’ experience. Pediatr Int (2007) 49:626–30. doi:10.1111/j.1442-200X.2007.02427.x
27. Durham MM, Ricketts RR. Neonatal gastric perforation and necrosis with Hunt-Lawrence pouch reconstruction. J Pediatr Surg (1999) 34:649–51. doi:10.1016/S0022-3468(99)90097-0
28. Kara CS, Ilçe Z, Celayir S, Sarimurat N, Erdogan E, Yeker D. Neonatal gastric perforation: review of 23 years’ experience. Surg Today (2004) 34:243–5. doi:10.1007/s00595-003-2675-3
29. Chung MT, Kuo CY, Wang JW, Hsieh WS, Huang CB, Lin JN. Gastric perforation in the neonate: clinical analysis of 12 cases. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi (1994) 35:460–5.
30. Babayigit A, Ozaydın S, Cetinkaya M, Sander S. Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. Pediatr Surg Int (2018) 34(1):79–84. doi:10.1007/s00383-017-4205-1
31. Morsi AH, Omar HR, Osama A, Khodary A. Clinical spectrum of neonates presenting with pneumoperitoneum: a retrospective study. Afr J Paediatr Surg (2016) 13:120–4. doi:10.4103/0189-6725.187804
32. Tang PMY, Hung JWS, Liu CSW, Leung MWY. An uncommon cause of neonatal gastric perforation: a case report. H K J Paediatr (2016) 21:109–12.
33. Mai C, Breysem L, De Hertogh G, Van Raemdonck D, Smet M-H. An unusual presentation of congenital esophageal stenosis due to tracheobronchial remnants in a newborn prenatally diagnosed with duodenal atresia. J Belg Soc Rad (2015) 99:43–6. doi:10.5334/jbr-btr.881
34. Rathod KK, Bawa M, Mahajan JK, Samujh R, Rao KLN. Management of esophageal atresia with a tracheoesophageal fistula complicated by gastric perforation. Surg Today (2011) 41:1391–4. doi:10.1007/s00595-010-4460-4
35. Gasparella M, Schiavon G, Bordignon L, Buffo M, Benetton C, Zanatta C, et al. Iatrogenic traumas by nasogastric tube in very premature infants: our cases and literature review. Pediatr Med Chir (2011) 33:85–8.
36. Asabe K, Oka Y, Kai H, Shirakusa T. Neonatal gastrointestinal perforation. Turk J Pediatr (2009) 51:264–70.
37. Anatol TI, Vilcov NS. Gastrointestinal perforation caused by obstruction in trinidadian neonates. Int Surg (2009) 94:111–4.
38. Im SA, Lim GY, Hahn ST. Spontaneous gastric perforation in a neonate presenting with massive hydroperitoneum. Pediatr Radiol (2005) 35:1212–4. doi:10.1007/s00247-005-1543-2
39. Abadir J, Emil S, Nguyen N. Abdominal foregut perforations in children: a 10-year experience. J Pediatr Surg (2005) 40:1903–7. doi:10.1016/j.jpedsurg.2005.08.048
40. Hall NJ, Ward HC. Lactobezoar with perforation in a premature infant. Biol Neonate (2005) 88:328–30. doi:10.1159/000087631
41. Rijhwano A, Sunil I. Intra thoracic gastric volvulus and perforation in congenital diaphragmatic hernia – a case report. Perinatology (2005) 7:156–7.
42. Antabak K, Bogović M, Vuković J, Grizel RJ, Babić VB, Papeš D, et al. Postoperative gastric perforation in a newborn with duodenal atresia. J Neonatal Surg (2016) 5:62. doi:10.21699/jns.v5i4.469
43. Piplani R, Acharya SK, Bagga D. Congenital duodenal obstruction, situs inversus totalis, and gastric perforation in a neonate. J Neonatal Surg (2017) 6:35. doi:10.21699/jns.v5i4.463
44. Reyna-Sepulveda F. Neonatal sleeve gastrectomy for multiple gastric perforations: a case report. J Neonat Surg (2017) 6:10. doi:10.21699/jns.v5i3.355
45. Sato M, Hamada Y, Kohno M, Ise K, Uchida K, Ogata H, et al. Neonatal gastrointestinal perforation in Japan: a nationwide survey. Pediatr Surg Int (2017) 33:33–41. doi:10.1007/s00383-016-3985-z
46. Uettwillera F, Roullet-Renoleaub N, Letouzec A, Lardyc H, Salibab E, Labarthe F. Gastric perforation in neonate: a rare complication of birth trauma. J Ped Surg Case Rep (2014) 2:212–4. doi:10.1016/j.epsc.2014.03.006
47. Ksia A, Zitouni H, Zrig A, Laamiri R, Chioukh F, Ayari E. Pyloric atresia: a report of ten patients. Afr J Paediatr Surg (2013) 10(2):192–4. doi:10.4103/0189-6725.115054
48. Lawther S, Patel R, Lall A. Neonatal gastric perforation with tension pneumo-peritoneum. J Pediatr Surg Case Rep (2013) 1:14–6. doi:10.1016/j.epsc.2013.02.004
49. Arpit M, Lurstep W, Susil L, Dhruv G. Bananas and neonatal gastric perforation. J Indian Assoc Pediatr Surg (2012) 17(2):88–9. doi:10.4103/0971-9261.93979
50. Kella N, Suhario AR, Soomro BA, Rathi PK, Qureshi MA. Gastric perforation in newborns: analysis of 14 cases. JLUMHS (2011) 10:163–7.
51. Erdogan D. Unusual presentation of gastric perforation in a neonate: subcutaneous emphysema and scrotal pneumatocele. J Coll Physicians Surg Pak (2013) 23:303–4. doi:04.2013/JCPSP.303304
52. Lee JJ, Ryu BY, Jang JS, Hwang SM. Two complications of tracheal intubation in a neonate: gastric perforation and lung collapse. Anesthesiology (2011) 115:858. doi:10.1097/ALN.0b013e31821b1971
53. Ohshiro K, Yamataka A, Kobayashi H, Hirai S, Miyahara K, Sueyoshi N, et al. Idiopathic gastric perforation in neonates and abnormal distribution of intestinal pacemaker cells. J Pediatr Surg (2000) 35:673–6. doi:10.1053/jpsu.2000.5940
54. Moher D, Liberati A, Tetzlaff J, Altman DG; The PRISMA Group. Preferred reporting/terms for systematic reviews and meta-analyses: the PRISMA Statement. PLoS Med (2009) 6(7): e1000097. doi:10.1371/joumal.pmed1000097
55. Okechukwu EH, Jideoffor U, Modekwe V, Osuigwe AN. Gastrointestinal perforation in neonates: aetiology and risk factors. J Neonatal Surg. (2013) 2(3): 30.
56. Abdullahi LB, Mohammad AM, Anyanwu LJC, Farinyaro AU. Two cases of neonatal gastric perforation. J Neonatal Surg (2015) 4(3):34.
57. He TZ, Xu C, Ji Y, Sun XY, Liu M. Idiopathic neonatal pneumoperitoneum with favorable outcome: a case report and review. World J Gastroenterol (2015) 21(20):6417–21. doi:10.3748/wjg.v21.i20.6417
58. Lyn TE, Kaftan GR. Neonatal gastric perforation. Am J Surg (1965) 110:956–7. doi:10.1016/0002-9610(65)90185-6
59. Houck WS, Griffin JA. Spontaneous linear tears of the stomach in the newborn infant. Ann Surg (1981) 193:763–8. doi:10.1097/00000658-198106000-00012
60. Inouye WY, Evans G. Neonatal gastric perforation. Arch Surg (1964) 88:471–85. doi:10.1001/archsurg.1964.01310210145024
Keywords: neonate, gastric perforation, prematurity, gastrointestinal emergency, pneumoperitoneum
Citation: Iacusso C, Boscarelli A, Fusaro F, Bagolan P and Morini F (2018) Pathogenetic and Prognostic Factors for Neonatal Gastric Perforation: Personal Experience and Systematic Review of the Literature. Front. Pediatr. 6:61. doi: 10.3389/fped.2018.00061
Received: 28 October 2017; Accepted: 02 March 2018;
Published: 04 April 2018
Edited by:
Eugene S. Kim, University of Southern California, United StatesReviewed by:
Richard Keijzer, University of Manitoba, CanadaAndrew John Anderson Holland, University of Sydney, Australia
Copyright: © 2018 Iacusso, Boscarelli, Fusaro, Bagolan and Morini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Chiara Iacusso, chiara.iacusso@gmail.com