Corrigendum: Blinatumomab for treating pediatric B-lineage acute lymphoblastic leukemia: A retrospective real-world study
Ying Wu1,† 
Yanming Li2,† Jia Fan1 Peijing Qi1 Wei Lin1 
Jie Yang1 Huiqing Liu1 
Xiaoling Wang2 Huyong Zheng1 
Tianyou Wang1* 
Ruidong Zhang1*
- 1Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
- 2Department of Pharmacy, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
A Corrigendum on
By Wu Y, Li Y, Fan J, Qi P, Lin W, Yang J, Liu H, Wang X, Zheng H, Wang T, Zhang R (2022). Front. Pediatr. 10:1034373. doi: 10.3389/fped.2022.1034373
There were errors in the published article. A correction has been made to Results, subsection Characteristics of the study population, paragraph two. “Eight subjects had high-risk genetic abnormalities, including 1 MLL arrangement, 4 IKZF1 deletion, and 3 Philadelphia chromosome-like cases” has been changed to “Ten subjects had high-risk genetic abnormalities, including 1 MLL rearrangement, 5 IKZF1 deletion, 3 Philadelphia chromosome-like and 1 TCF3-ZNF384 cases.”
A correction has been made to Results, subsection Characteristics of the study population, paragraph three. “Three of all patients received 2 blinatumomab cycles, and 22 underwent one cycle with one stopping blinatumomab therapy on the second day because of serious seizure” has been changed to “Four of all patients received 2 blinatumomab cycles, and 19 underwent one cycle with one stopping blinatumomab therapy on the second day because of serious seizure.”
A correction has been made to Results, subsection Clinical efficacy, paragraph one. “Totally 20 patients with chemotherapy-associated toxicity recovered and bridged to maintenance therapy in the CCLG-2018-preB-ALL” has been changed to “15 patients with chemotherapy-associated toxicity recovered and bridged to maintenance therapy in the CCLG-2018-preB-ALL.”
A correction has been made to Results, subsection Safety, paragraph one. “A total of 106 AEs were reported, including 58.5% of grade 1–2 and 41.5% of grade 3–4” has been changed to “A total of 108 AEs were reported, including 58.3% of grade 1–2 and 41.6% of grade 3–4.”
A correction has been made to Results, subsection Safety, paragraph one. “The rates of grade 3–4 adverse events included febrile neutropenia (29%), white blood cell decrease (30%), seizure (2%), hepatotoxicity (2%) and fever (2%)” has been changed to “The rates of grade 3–4 adverse events included febrile neutropenia (57%), white blood cell decrease (48%), thrombocytopenia (4%), seizure (4%), hepatotoxicity (4%) and fever (13%).”
A correction has been made to Results, subsection Lymphocyte and cytokine levels. “The median count of CD3+ T cells was 1.148 × 109 /l at baseline vs. 1.7 × 109 /l at the end of blinatumomab treatment (Supplementary Table S1)” has been changed to “The median count of CD3+ T cells was 0.725 × 109 /L at baseline vs. 1.32 × 109 /L at the end of blinatumomab treatment (Supplementary Table S1)”.
A correction has been made to Results, subsection Lymphocyte and cytokine levels. “The absolute counts of Tregs slightly increased from a median of 9.46 at baseline to 11.31 on Day 27 (p = 0.47)” has been changed to “The absolute counts of Tregs slightly increased from a median of 7.59 at baseline to 10.06 on Day 27 (p = 0.128).”
A correction has been made to Results, subsection Safety, paragraph two. “CRS was observed in 3 patients (10.5%)” has been changed to “CRS was observed in 3 patients (13.0%).”
A correction has been made to Results, subsection Lymphocyte and cytokine levels, paragraph one. “High levels of cytokines were observed in 3 patients (Figures 3, 4)” has been changed to “High levels of cytokines were observed in 4 patients (Figure 4).”
A correction has been made to Discussion. “we evaluated the safety, efficacy, B and T cell responses, and cytokine release of blinatumomab for 20 children with B-ALL based on a large sample size” has been changed to “we evaluated the safety, efficacy, B and T cell responses, and cytokine release of blinatumomab for 23 children with B-ALL based on a large sample size.”
Error in the Ethics statement
Furthermore, a change was made to the Ethics statement: “The studies involving human participants were reviewed and approved by This study was approved by the Institutional Review Boards of Beijing Children's Hospital ([2022]-E-090-R)” has been changed to “The study involving human participants was reviewed and approved by the Institutional Review Boards of Beijing Children's Hospital ([2022]-E-090-R).”
Error in Tables
In the published article, there was an error in Table 2. The number of patients proceeding to maintenance therapy should have been written as 18 instead of 16. The corrected Table 2 and its caption appear in the following.
Finally, in Table 3, the number and percentage of Grades 1–2 cytokine release syndrome in all patients, Grades 1–2 cytokine release syndrome in the Chemo-ineligible group, and PICC-venous thrombosis in the MRD-positive group were incorrect and the number and percentage of Rash maculopapular in the MRD-positive Group were missed. The corrected Table 3 and its caption appear in the following.
The authors apologize for these errors and state that these do not change the scientific conclusions of the article in any way. The original article has been updated.
Table 2. Efficacy outcomes of 23 patients with B-ALL.
Table 3. Adverse events according to CTCAE v 5.0.
Keywords: b-cell acute lymphoblastic leukemia, blinatumomab, pediatric, minimal residual disease, real world
Citation: Wu Y, Li Y, Fan J, Qi P, Lin W, Yang J, Liu H, Wang X, Zheng H, Wang T and Zhang R (2022) Corrigendum: Blinatumomab for treating pediatric B-lineage acute lymphoblastic leukemia: A retrospective real-world study. Front. Pediatr. 10:1083730. doi: 10.3389/fped.2022.1083730
Received: 29 October 2022; Accepted: 11 November 2022;
Published: 12 December 2022.
Edited and Reviewed by: Yang Su, Xuzhou Medical University, China
© 2022 Wu, Li, Fan, Qi, Lin, Yang, Liu, Wang, Zheng, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Tianyou Wang wangtianyou@bch.com.cn Ruidong Zhang zhangruidong@vip.sina.com
†These authors share first authorship
Specialty Section: This article was submitted to Pediatric Hematology and Hematological Malignancies, a section of the journal Frontiers in Pediatrics