There was an error in Figure 2 and Figure 6 as published. Figure 6A,C were disorganized because the GAPDH control for the same sample (PPI-treated MKN-45 cells) were unnecessarily shown twice. In addition, Figure 2E was already included in Figure 4A since both figures were derived from the same experiment. The original Figure 2E has been removed and accordingly replaced with the original Figure 2F, while Figures 6A,C have been combined into a single Figure 6A panel.
FIGURE 2
FIGURE 6
A correction has been made to the Results section, subsection PPI inhibits the growth of gastric cancer cells in vitro and induces their ferroptosis: “In addition, using a specific fluorescent probe, FerroOrange, we revealed that PPI increased the levels of ferrous ions in both AGS and MKN-45 cells (Figure 2E,F)” is corrected to “In addition, using a flow cytometer, we revealed that PPI increased the levels of ferrous ions in both AGS and MKN-45 cells (Figure 2E).”
A correction has been made to the Results section, subsection PPI downregulates NRF2 and FTH1 in the gastric cancer cells: “Using Western blot assays to detect ferroptosis-related proteins in the cancer cells after PPI treatment in vitro, we found that PPI downregulated the expression of both NRF2 (Figures 6A,B) and FTH1 (Figures 6C,D) in both AGS and MKN-45 cancer cells, indicating that PPI-induced ferroptosis in the gastric cancer cells is associated with its regulation of NRF2/FTH1 pathway.” is corrected to “Using Western blot assays to detect ferroptosis-related proteins in the cancer cells after PPI treatment in vitro, we found that PPI downregulated the expression of both NRF2 and FTH1 (Figure 6A) in both AGS and MKN-45 cancer cells, whereas Liproxstain-1 largely reversed this effect of PPI (Figure 6B), indicating that PPI-induced ferroptosis in the gastric cancer cells is associated with its regulation of NRF2/FTH1 pathway.”.
The corrected Figure 2 and Figure 6, and their captions appear below. The authors apologize for the errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
ferroptosis, gastric cancer, NRF2, polyphyllin I, anticancer drug
Citation
Zheng F, Wang Y, Zhang Q, Chen Q, Liang C, Liu H, Qiu F, Chen Y, Huang H, Lu W and Dai Z (2023) Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis. Front. Pharmacol. 14:1201715. doi: 10.3389/fphar.2023.1201715
Received
07 April 2023
Accepted
19 April 2023
Published
03 May 2023
Volume
14 - 2023
Edited and reviewed by
Zhijie Xu, Central South University, China
Updates
Copyright
© 2023 Zheng, Wang, Zhang, Chen, Liang, Liu, Qiu, Chen, Huang, Lu and Dai.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Weihui Lu, weihui.lu@gzucm.edu.cn; Zhenhua Dai, zdai2009@outlook.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.