Introduction
“I think the next Frontier in precision genomic medicine is figuring out how to circumvent resistance,” said Laurie H. Glimcher, M.D., president and CEO of Dana-Farber Cancer Institute, at a lecture at the National Institutes of Health on 7 November 2016 (National Cancer Institute, Why Do Cancer Treatments Stop Working? Overcoming Treatment Resistance, 2016). Drug resistance and tumor metastasis remain formidable obstacles in the effective treatment of cancer, contributing to treatment failure and poor patient outcomes (Chaffer and Weinberg, 2011; Gao et al., 2014; Gottesman et al., 2016; Steeg, 2016; Lambert et al., 2017; Fares et al., 2020; Yang et al., 2020; Nussinov et al., 2021; Labrie et al., 2022). Understanding the underlying mechanisms driving drug resistance and metastatic spread is crucial for devising novel therapeutic strategies to combat these challenges. This Research Topic seeks to compile recent advancements in elucidating drug resistance mechanisms associated with metastasis and cancer progression, while also exploring innovative approaches to develop new anti-cancer agents capable of overcoming these obstacles. Contributions are welcomed on Research Topic ranging from novel anti-cancer strategies and mechanisms of drug resistance and metastasis to innovative approaches aimed at enhancing therapeutic efficacy against metastatic cancers.
Unraveling drug resistance in metastatic colorectal cancer: key pathways
Currently, colorectal cancer ranks as the third most common and deadliest cancer globally, with 20% of patients presenting with metastatic CRC (mCRC) at diagnosis and another 25% developing metastases later (Biller and Schrag, 2021). Despite advances in treatment modalities such as chemotherapy and targeted therapies, the prognosis of patients with mCRC remains poor with a 5-year survival rate of only 14%, largely due to therapeutic resistance. Albadari et al. highlights the major resistance mechanisms in mCRC, particularly focusing on drug transporters, EGFR mutations, and the HGF/c-MET signaling pathway, which promote tumor invasion and metastasis, and discusses emerging strategies to overcome these challenges.
Advances and challenges in ovarian cancer treatment: A decade of research on drug resistance and poly ADP-Ribose polymerase inhibitors
Liu et al. analyzes the trends in ovarian cancer and chemotherapy resistance research from 2013 to 2022 using bibliometric software such as CiteSpace and VosViewer, examining data from the Web of Science Core Research Topic. There is an increasing focus on understanding the mechanisms underlying drug resistance and the clinical efficacy of poly ADP-ribose polymerase inhibitors (PARPis) and the antiangiogenic agent bevacizumab, with significant contributions from Chinese researchers and institutions. The findings highlight ongoing challenges in overcoming drug resistance, suggesting a need for innovative treatment strategies and further exploration of resistance mechanisms.
Furthermore, Dong et al. discusses the increasing incidence of ovarian cancer in China and the clinical use of PARPis that target DNA repair enzymes to treat tumors with homologous recombination dysfunction, particularly in advanced ovarian epithelial cancer. This review highlights the growing challenge of intrinsic or acquired PARPi resistance and summarizes current advances in combination strategies to enhance PARPi efficacy.
Advancements in small molecule therapies targeting estrogen receptors in breast cancer
The estrogen receptor (ER) is integral to multiple signaling pathways. Its targeting therapies, including selective estrogen receptor modulators (SERMs) such as tamoxifen, play pivotal roles in inhibiting breast cancer cell proliferation, among other benefits. However, challenges such as drug resistance and side effects on tissues expressing high levels of ER such as the endometrium complicate their clinical use. Yao et al. discusses recent developments in novel ER-targeted drugs, specifically selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs), focusing on their optimization and potential in treating breast cancer and other ER-related conditions.
Identification of new benzylquinazoline compounds as inhibitors of p97/VCP
In a study by Zhang et al., novel DBeQ analogs were synthesized and evaluated as potential inhibitors of the ATPase valosin-containing protein (VCP/p97). Compounds 6 and 7 in this report exhibited higher potency than known inhibitors, inducing cell cycle arrest and modulating key signaling pathways. Moreover, compound 6 demonstrated promising antitumor effects and reduced toxicity in vivo, suggesting its potential as a selective and effective p97 inhibitor with improved clinical prospects.
SAF-189s potently inhibits lorlatinib-resistant NSCLC with ALK mutations L1196M and D1203N
Li et al. present a clinical case of metastatic ALK-rearranged NSCLC developing rare, acquired compound ALK mutations (L1196M and D1203N) conferring resistance to lorlatinib. The patient showed stable and controlled disease progression with SAF-189s treatment for 3 months, followed by a partial response to chemotherapy (pemetrexed-carboplatin) with bevacizumab, maintained for 7 months. This study offered valuable insights, suggesting that combination of SAF-189s and chemotherapy may be potential therapeutic options for NSCLC patients with ALK L1196M/D1203N compound mutations.
Olverembatinib monotherapy: a chemo-free option for elderly patients with relapsed Ph-positive ALL
The introduction of BCR/ABL1 tyrosine kinase inhibitors (TKIs) has significantly improved outcomes for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ -ALL) patients, but relapse remains common due to acquired drug resistance. Third generation TKIs such as olverembatinib are promising solutions. In this case report by Ding and Li, a 79-year-old female patient with relapsed Ph+ -B-ALL, despite frailty, achieved a second complete molecular remission (2nd CMR) with olverembatinib monotherapy, suggesting its potential as a safe and effective chemo-free option for elderly Ph+-ALL patients experiencing relapse after prior therapy.
Perspectives
In summary, this Research Topic aimed to advance our understanding of drug resistance mechanisms, to showcase the development of novel anti-cancer agents, and clinical examples of combination therapy and new generation of targeted therapy to combat metastases. With the collaborative effort contributed to this Research Topic, we strive to make meaningful progress in overcoming drug resistance, alleviating the burden of metastatic cancers and improving patient outcomes.
We extend our sincere appreciation to the authors for their valuable contributions, and we express our gratitude to the reviewers for their expert evaluations and generous dedication of time and efforts.
Statements
Author contributions
EW: Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing–original draft, Writing–review and editing. ZW: Writing–review and editing. C-YY: Writing–review and editing. DQ: Writing–review and editing. XH: Writing–review and editing. WL: Funding acquisition, Resources, Supervision, Validation, Writing–review and editing, Conceptualization, Project administration.
Funding
The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work is supported by the Corbett Estate Fund for Cancer Research (no. 62285-531021-41800, 62285-531021-51800, 62285-531021-61800 and 62285-531021-71800; recipient EW), the William and Ella Owens Medical Research Foundation (no. 43502512000; recipient EW), the University of Tennessee College of Pharmacy Drug Discovery Center Funds (WL), and the National Natural Science Foundation of China (No. 31970692) (XH), the Natural Science Foundation of Hunan Province (No.2023JJ30124) (XH), the Guangdong Basic and Applied Basic Research Foundation (No. 2024A1515012771) (XH), the Natural Science Foundation of Fujian Province (No. 2023J01247) (XH), the Natural Science Foundation of Chongqing (No. CSTB2022NSCQ-MSX1551) (XH).
Acknowledgments
We thank the editorial office for their invaluable assistance throughout the publication process.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Summary
Keywords
drug resistance, metastasis, cancer treatment, anti-cancer agents, resistance mechanisms, therapeutic strategies
Citation
Wu E, Wu Z, Yang C-Y, Qi D, Hu X and Li W (2024) Editorial: Managing cancer metastasis by tackling anticancer drug resistance. Front. Pharmacol. 15:1432248. doi: 10.3389/fphar.2024.1432248
Received
13 May 2024
Accepted
23 May 2024
Published
10 June 2024
Volume
15 - 2024
Edited and reviewed by
Olivier Feron, Université catholique de Louvain, Belgium
Updates
Copyright
© 2024 Wu, Wu, Yang, Qi, Hu and Li.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Erxi Wu, Erxi.wu@bswhealth.org; Wei Li, wli@uthsc.edu
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.