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Front. Psychiatry | doi: 10.3389/fpsyt.2018.00715

Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric disorders?

 Jens Stepan1, Elmira Anderzhanova2 and  Nils C. Gassen2*
  • 1Max-Planck-Institut für Psychiatrie, Germany
  • 2Klinik und Poliklinik für Psychiatrie und Psychotherapie Universitätsklinikum Bonn, Germany

Discovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration. Upon diverse extracellular and intracellular stimuli, Hippo signaling regulates stemness, cell proliferation and apoptosis by a well conserved signalling cascade, and disruption of these systems has been implicated in cancer as well as metabolic and neurodegenerative diseases. The central role of Hippo signaling in cell biology also results in prominent links to stress-regulated pathways. Genetic variations, epigenetically provoked upregulation of Hippo pathway members and dysregulation cellular processes implicated in learning and memory, are linked to an increased risk of stress-related psychiatric disorders (SRPDs). In this review, we summarize recent findings, supporting the role of Hippo signaling in SRPDs by canonical and non-canonical Hippo pathway interactions.

Keywords: Hippo pathway, KIBRA, Psychophysiological stress, synaptic plasticity, Glucocorticoids, GPCR (G-protein-coupled receptors)

Received: 14 Oct 2018; Accepted: 06 Dec 2018.

Edited by:

Naguib Mechawar, McGill University, Canada

Reviewed by:

Antoine Besnard, Massachusetts General Hospital, Harvard Medical School, United States
Emmanuel MOYSE, Université de Tours, France  

Copyright: © 2018 Stepan, Anderzhanova and Gassen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Nils C. Gassen, Klinik und Poliklinik für Psychiatrie und Psychotherapie Universitätsklinikum Bonn, Bonn, 53105, North Rhine-Westphalia, Germany, ncgassen@psych.mpg.de