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Front. Psychiatry | doi: 10.3389/fpsyt.2019.00615

Psychological Resilience Enhances the Orbitofrontal Network in the Elderly with Mild Cognitive Impairment

 Sang Joon Son1,  Bumhee Park2, 3, Jin Wook Choi4, Hyun Woong Roh3,  Narae Kim1,  Jae Eun Sin2, Heana Kim1,  Hyun Kook Lim5* and Chang Hyung Hong1*
  • 1Department of Psychiatry, School of Medicine, Ajou University, South Korea
  • 2Department of Biomedical Sciences, Graduate School, Ajou University, South Korea
  • 3School of Medicine, Ajou University, South Korea
  • 4Department of Radiology, School of Medicine, Ajou University, South Korea
  • 5Yeouido St. Mary’s Hospital, Catholic University of Korea, South Korea

Background: It has been suggested that maintaining the efficient organization of the brain’s functional connectivity (FC) supports neuroflexibility under neurogenerative stress. This study examined psychological resilience related FC in one hundred twelve older adults with mild cognitive impairment.
Methods: Using a resting-state functional magnetic resonance imaging (fMRI) approach, we investigated reorganization of the orbitofrontal gyrus (OFG)/ amygdala (AMG)/ hippocampus (HP)/ parahippocampal gyrus (PHG) FC according to the different level of resilience scale.
Results: Compared with the low resilient group, the high resilient group had greater connectivity strengths between the left inferior OFG and right superior OFG (P<0.05, Bonferroni corrected), between the right inferior OFG and left PHG (P<0.05, Bonferroni corrected), and between the right middle OFG and left PHG (False Discovery Rate<0.05).
Conclusion: Psychological resilience may be associated with enhancement of the orbitofrontal network in the elderly with MCI.

Keywords: Resilience (psychological), functional connectivity (FC), fMRI — functional magnetic resonance imaging, Elderly, Orbito frontal cortex

Received: 05 Mar 2019; Accepted: 01 Aug 2019.

Copyright: © 2019 Son, Park, Choi, Roh, Kim, Sin, Kim, Lim and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD, PhD. Hyun Kook Lim, Yeouido St. Mary’s Hospital, Catholic University of Korea, Soeul, South Korea,
MD, PhD. Chang Hyung Hong, Department of Psychiatry, School of Medicine, Ajou University, Suwon, South Korea,