@ARTICLE{10.3389/fpsyt.2021.659616, AUTHOR={Murayama, Keitaro and Tomiyama, Hirofumi and Tsuruta, Sae and Ohono, Aikana and Kang, Mingi and Hasuzawa, Suguru and Mizobe, Taro and Kato, Kenta and Togao, Osamu and Hiwatashi, Akio and Nakao, Tomohiro}, TITLE={Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder}, JOURNAL={Frontiers in Psychiatry}, VOLUME={12}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fpsyt.2021.659616}, DOI={10.3389/fpsyt.2021.659616}, ISSN={1664-0640}, ABSTRACT={Background: Although abnormality of cerebellar-cerebral functional connectivity at rest in obsessive-compulsive disorder (OCD) has been hypothesized, only a few studies have investigated the neural mechanism. To verify the findings of previous studies, a large sample of patients with OCD was studied because OCD shows possible heterogeneity.Methods: Forty-seven medication-free patients with OCD and 62 healthy controls (HCs) underwent resting-state functional magnetic imaging scans. Seed-based connectivity was examined to investigate differences in cerebellar-cerebral functional connectivity in OCD patients compared with HCs. Correlations between functional connectivity and the severity of obsessive-compulsive symptoms were analyzed.Results: In OCD, we found significantly increased functional connectivity between the right lobule VI and the left precuneus, which is a component of the default mode network (DMN), compared to HCs. However, there was no correlation between the connectivity of the right lobule VI-left precuneus and obsessive-compulsive severity.Conclusions: These findings suggest that altered functional connectivity between the cerebellum and DMN might cause changes in intrinsic large-scale brain networks related to the traits of OCD.} }