Editorial: Optimising Antibiotic Use: Social and Contextual Issues
Carolyn Tarrant
Eva Maria Krockow
Emily Kate Rousham
Björn Rönnerstrand- 1Department of Health Sciences, University of Leicester, Leicester, United Kingdom
- 2Department of Neuroscience, Psychology and Behavior, University of Leicester, Leicester, United Kingdom
- 3School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom
- 4The SOM Institute, University of Gothenburg, Gothenburg, Sweden
Editorial on the Research Topic
Optimising Antibiotic Use: Social and Contextual Issues
Modern medicine is founded on the availability of effective antimicrobials, but antibiotic resistance is an inevitable consequence of widespread use of antibiotics. The rise in multidrug resistant organisms, and the increasing numbers of pan-resistant infections being identified, mean that antimicrobial resistance (AMR) is now a pressing global concern (Jee et al., 2018).
The factors contributing to the growth and spread of AMR are multiple and intertwined, including antibiotic use in human and animal health and agriculture, hygiene and sanitation, and international travel. Overuse of antibiotics in healthcare is a contributing factor, with evidence suggesting that around 30% of antibiotics in hospitals are prescribed or taken inappropriately (Fridkin et al., 2014). The global COVID-19 pandemic has led to increased antibiotic prescribing and made it more difficult to maintain efforts to optimize antibiotic use (Getahun et al., 2020).
Given the global nature of the threat of AMR, efforts are underway to tackle the problem using approaches such as policy, regulation, and international coordination. Alongside these macro-level approaches, an extensive body of research and interventions focuses on understanding and changing the behaviors of individuals—health professionals and patients—to reduce antibiotic use (Charani et al., 2011). In contrast, meso-level issues, including the social and organizational context in which antibiotic use takes place, have received less attention. Prescribing behavior is socially and contextually embedded—influenced by identities, attitudes, social norms, hierarchy, local culture and systems (Charani et al., 2013; Broom et al., 2016). Antibiotic use involves a range of stakeholders and institutions (Broom et al., 2019). The articles in this Research Topic provide insights into the complex and embedded nature of antibiotic use.
Five of the articles in this Research Topic consider antibiotic prescribing and antimicrobial stewardship (programmes to optimize antibiotic use) in healthcare. The first article in the collection, by Rzewuska et al., sets the scene by reviewing the literature on antimicrobial stewardship interventions in hospitals in high income countries. The authors identify that efforts to change physician prescribing behavior are frustrated by contextual factors—inadequate information systems and unavailability of key personnel and funding—as well as facing competition from other initiatives seen as having a higher priority.
Rynkiewich's article goes further by challenging a common assumption of antibiotic stewardship approaches—that the problem lies in individual physician behaviors and habits. Based on vivid ethnographic case studies in two American hospitals, the author argues that decision-making about antibiotics is instead a collective practice, which happens between institutions, physicians, pharmacists, nurses, and other staff. The implications are that, rather than targeting “bad” physician practice, stewardship efforts should recognize the collective nature of antibiotic use.
Tarrant et al. look in detail at the notion of “inappropriate” antibiotic prescribing in their interview study, involving hospital prescribers in the UK, South Africa and Sri Lanka. They identify that prescriber definitions of inappropriate antibiotic use are not purely objective. Inappropriate antibiotic use can't be pinned down by precise technical definitions. Instead, prescribers' judgements about the appropriateness of prescribing decisions reflect their moral position and the context in which they work.
Shifting the focus to China, Chen et al.'s qualitative study provides another example of the complexities of antibiotic decision-making, this time in rural primary care. They find that physicians work to balance their understanding of rational use of antibiotics against the need to maintain good relationships and protect the safety of their patients. The idea of “suzhi” (human quality)—respecting and protecting their patients—is drawn on by prescribers to explain their liberal prescribing of antibiotics.
How patients and professionals perceive suspected infection is consequential for antibiotic use. Saukko and Rousham's article focuses on patients' and health professionals' affective experiences related to diagnosis and management of urinary tract infections. Using the conceptual framing of illness narratives, they describe narratives of chaos and control, and point to the need for stewardship programmes to consider the affective dimension of decision-making about antibiotic use.
The majority of efforts to tackle AMR to date have focused on the preservation of existing antibiotics through stewardship, and investment in development of new antibiotics. The final article in this Topic, by Jamie and Sharples, offers a refreshingly different perspective. The authors describe how natural materials such as clay may offer alternatives to antibiotic treatment. They provide some theoretical lenses through which sociologists could study how their materiality (i.e., what they are made from, what they look like, how they are produced) might influence the use of these materials in healthcare.
Taken together, the articles illuminate the ways in which the use of antibiotics (and materials with antibacterial properties) are shaped by social and organizational infrastructures, individual meaning-making, as well as the materiality of the substances themselves. Addressing AMR will require us to think differently about the nature of the problem and about our possible futures (Chandler, 2019). This Research Topic offers some new perspectives to stimulate further research.
Author Contributions
The authors confirm being the only contributors of this work and approved it for publication. All authors contributed to the article and approved the submitted version.
Funding
CT & EMK were funded through Global Challenges Research Fund-Grant No. ES/P004784/1 awarded by the Economic and Social Research Council (ESRC) on behalf of the Research Councils United Kingdom (RCUK).
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Broom, A., Broom, J., Kirby, E., and Adams, J. (2016). The social dynamics of antibiotic use in an Australian hospital. J. Sociol. 52, 824–839. doi: 10.1177/1440783315594486
Broom, J., Broom, A., and Kirby, E. (2019). The drivers of antimicrobial use across institutions, stakeholders and economic settings: a paradigm shift is required for effective optimization. J. Antimicrob. Chemother. 74, 2803–2809. doi: 10.1093/jac/dkz233
Chandler, C. I. (2019). Current accounts of antimicrobial resistance: stabilisation, individualisation and antibiotics as infrastructure. Palgrave Commun. 5, 1–3. doi: 10.1057/s41599-019-0263-4
Charani, E., Castro-Sanchez, E., Sevdalis, N., Kyratsis, Y., Drumright, L., Shah, N., et al. (2013). Understanding the determinants of antimicrobial prescribing within hospitals: the role of “prescribing etiquette”. Clin. Infect. Dis. 57, 188–196. doi: 10.1093/cid/cit212
Charani, E., Edwards, R., Sevdalis, N., Alexandrou, B., Sibley, E., Mullett, D., et al. (2011). Behavior change strategies to influence antimicrobial prescribing in acute care: a systematic review. Clin. Infect. Dis. 53, 651–662. doi: 10.1093/cid/cir445
Fridkin, S. K., Baggs, J., Fagan, R., Magill, S., Pollack, L. A., Malpiedi, P., et al. (2014). Vital signs: improving antibiotic use among hospitalized patients. MMWR Morb. Mortal Wkly. Rep. 63, 194–200. Available online at: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6309a4.htm?s_cid=mm6309a4_w
Getahun, H., Smith, I., Trivedi, K., Paulin, S., and Balkhy, H. H. (2020). Tackling antimicrobial resistance in the COVID-19 pandemic. Bull. World Health Org. 98:442. doi: 10.2471/BLT.20.268573
Keywords: antibiotic prescribing, social theory, behavior, context, antimicrobial resistance
Citation: Tarrant C, Krockow EM, Rousham EK and Rönnerstrand B (2021) Editorial: Optimising Antibiotic Use: Social and Contextual Issues. Front. Sociol. 5:620048. doi: 10.3389/fsoc.2020.620048
Received: 21 October 2020; Accepted: 11 December 2020;
Published: 12 January 2021.
Edited and reviewed by: Nicola Kay Gale, University of Birmingham, United Kingdom
Copyright © 2021 Tarrant, Krockow, Rousham and Rönnerstrand. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Carolyn Tarrant, ccp3@le.ac.uk