Frontiers in Cardiovascular Medicine

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Journal notices

New Review: The Heart-Brain Axis and Its Clinical Impact

From gut bacteria to brain inflammation, new evidence reveals surprising ways the heart and brain damage each other. Michael Y. Henein, Specialty Chief Editor for Heart Failure and Transplantation, coauthors this comprehensive review.

Rheumatic Heart Disease: global trends and emerging mechanisms

A preventable disease still claiming young lives. This ISACB-led collection explores RHD’s global epidemiology and the biology behind rheumatic valve injury—autoimmunity, fibrosis, sex-specific responses, omics, and vaccines. Submit by 30 September 2026.

Reimagining cardiac rehabilitation: lessons from history for a post‑MI future

Explore how cardiac rehabilitation evolved from strict bed rest to modern post‑MI care. Julie Redfern (University of Sydney) and Tom Briffa (University of Western Australia) trace its history and outline how programs must modernize for today’s patients

Featured Article: Update on Sex-Specific Risk Factors in Cardiovascular Disease

Pregnancy, menopause, PMOS: Dr. Garima Sharma, Director of Inova's Women's Heart Program and a leading voice in women's cardiovascular health, reveals how reproductive history reshapes heart disease risk. Revisit the review driving today’s conversation.

Sea buckthorn: an ancient berry with modern cardiovascular potential

Rich in flavonoids, omega fatty acids and polyphenols, sea buckthorn shows measurable effects on inflammation, lipid metabolism, oxidative stress and platelet activity — positioning it as a promising natural strategy for cardiovascular disease.

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Frontiers in Cardiovascular Medicine

Submit your research

Author guidelines

Editor guidelines

Peer review

Publishing fees

Journal notices

New Review: The Heart-Brain Axis and Its Clinical Impact

Rheumatic Heart Disease: global trends and emerging mechanisms

Reimagining cardiac rehabilitation: lessons from history for a post‑MI future

Featured Article: Update on Sex-Specific Risk Factors in Cardiovascular Disease

Sea buckthorn: an ancient berry with modern cardiovascular potential

Editors

masanori aikawa

hendrik tevaearai stahel

jun-ichi abe

elena aikawa

Articles

Dose Reduction and Discontinuation of Sacubitril/Valsartan Over Time in Patients Undergoing Maintenance Hemodialysis

A scale for Measuring Cardiac Rehabilitation Motivation in Coronary Heart Disease Patients: A development and validation Study

A Second-Hit Conceptual Framework for Pulmonary Arterial Hypertension in Adult Congenital Heart Disease: Genetics, Hemodynamics, and Treat-and-Repair

Potential Association Between Chronic Alpha-1 Adrenergic Blockade and Early Epinephrine-Related Resuscitation Profiles During Cardiac Arrest: A Retrospective Exploratory Cohort Study

Atherosclerosis and Vascular Medicine

Decoding the Crosstalk: Interplay Between Macrophage Programmed Cell Death Networks and Cholesterol Efflux

Pathological mechanisms of inflammatory responses in atherosclerosis and the multi-target regulatory effects of traditional Chinese medicine

Macrophage-Associated Noncoding RNAs in Atherosclerosis and Chronic Kidney Disease

Gut microbiota-derived metabolites in cardiovascular disease: mechanisms, disease-specific roles, and translational opportunities

Angiotensin II–driven coronary vasculopathy and pressure-overload myocardial remodeling represent distinct vascular phenotypes

Higher remnant cholesterol to lymphocyte ratio is associated with vulnerable plaque features in acute coronary syndrome

PCSK9 inhibitors for lipid-lowering treatment in patients with atherosclerotic cardiovascular disease: A health technology assessment

Correction: The dual role of metabolic reprogramming in macrophage polarization in rheumatoid arthritis and coronary heart disease and the intervention strategy of traditional Chinese medicine

Association of the Triglyceride-Glucose Index and Phlegm-Dampness Constitution with Subclinical Carotid Atherosclerosis in Overweight and Obese Individuals

High Density Lipoproteins and Extracellular Vesicles – Distinct but Overlapping Circulating Particles and Their Role in Atherosclerosis

Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population

Protein lactylation in myocardial ischemia-reperfusion injury: mechanisms and therapeutic potential

Carotid Bifurcation Reconstruction as a Novel CEA Modification to Address Complex Carotid Lesions

Formononetin Relieves Chronic Stress-related Neointimal Hyperplasia in Mice by Regulating HDAC6

Magnetocardiography in diagnosis of MINOCA: a case series

Single-cell RNA sequencing pseudobulk analysis and machine learning identify candidate biomarkers for ischemic cardiomyopathy

Heart Valve Disease

Thoracic aortic disease in young patients: from genetics to management

Efficacy and safety of different antithrombotic treatment regimens in patients undergoing transcatheter mitral valve repair and atrial fibrillation; A meta-analysis and systematic review

Early predictive value of prediction models for mortality after transcatheter aortic valve replacement: a systematic review and meta-analysis

Community-informed trial design and implementation to optimize recruitment and retention in low-income settings: lessons from rheumatic heart disease trials in Uganda

Artificial intelligence technology in aortic valve disease: a decade of scientometric and narrative review

Long non-coding RNAs as molecular hubs integrating inflammatory and osteogenic pathways in calcific aortic valve disease

Unimodal to multimodal: a systematic review of predictive machine learning models for valvular heart diseases

Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation

Surgical vs. trans-catheter aortic valve replacement in patients With bicuspid aortic valve stenosis

Implementation of a National Rheumatic Fever and Rheumatic Heart Disease prevention and control Program in Egypt: Rationale and Objectives

Commentary: Mechanisms of mitral valve development and disease

Correction: Factors associated with recurrence of mitral regurgitation 14 days after rheumatic mitral valve repair

Acute aortic regurgitation due to aortic valve leaflet injury during percutaneous coronary intervention: a case report

Clinical characteristics and predictors of adverse outcomes in children with acute rheumatic fever from a high-endemic region of Brazil

The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential

Patient perspectives of prosthetic heart valve choice and anticoagulation in patients with rheumatic heart disease: a semi-quantitative study

Cardiovascular Surgery

Preoperative identification and multidisciplinary management of von Willebrand disease in atrial septal defect closure: a case report

Traumatic brain injury in patients with mechanical heart valves on lifelong anticoagulation: incidence, management, and outcomes of intracranial hemorrhage

The molecular signature of degeneration in explanted decellularized allogeneic heart valves

Real-World Data on Aortic Endografts: Gore Together Aortic Post-Market Registry Protocol

Type B intramural aortic hematoma: conservative management or early intervention? A case of rapid progression to aortic dissection

Relationship between stress hyperglycemia ratio and gastrointestinal bleeding and mortality after coronary artery bypass grafting: a multicenter cohort study

Aortic manipulation proxy score predicts early stroke after isolated coronary artery bypass grafting: an international multicenter cohort study

Minimally invasive management of Stanford B aortic dissection involving the left subclavian artery

Aortoileal fistula following endovascular repair of an abdominal aortic aneurysm: a case report

Mitochondrial-Inflammatory Coupling in HFpEF: An Emerging Mechanistic Framework for Understanding the Cardioprotective Effects of SGLT2 Inhibitors

Does sternal-sparing outweigh prolonged bypass? inflammatory resolution in MICS versus median sternotomy: a SIRI-based analysis

Multidisciplinary surgery for intravenous leiomyomatosis with inferior vena cava and/or intracardiac extension: a case series

Determinants of Graft Patency After Coronary Artery Bypass Grafting

Rhythm vs. rate control for treatment of postoperative atrial fibrillation after cardiac surgery: a systematic review and meta-analysis of randomized controlled trials

Surgery improves survival rate in patients with Takayasu arteritis: a retrospective observational study

Case Report: 26-Year Follow-Up After Total Cavopulmonary Connection in Crisscross Heart—Longitudinal Assessment of Anastomotic Patency, Biomarkers, and Arrhythmia Progression

Thrombosis and Haemostasis

The Use of Direct Oral Anticoagulants in Children with Congenital and Acquired Heart Disease

Interpretable machine learning and mendelian randomization identify risk factors for lower extremity arterial embolism and thrombosis

Deep Learning Algorithm Enables Lower Limb Venous Thrombosis Detection with CT Venography

Efficacy and Safety of Low-Dose Thrombolysis in Intermediate-Risk Pulmonary Embolism: A Meta-Analysis

Intestinal Necrosis in a Patient with Behçet's Disease and Infective Endocarditis: A Case Report

Correlation between red blood cell distribution width and deep vein thrombosis in patients with lower limb fractures