Frontiers in Aging Neuroscience

Original Research

Published on 25 Jul 2025

Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment

in Parkinson’s Disease and Aging-related Movement Disorders

Guo Hong
Fengju Mao
Mingming Zhang
Fei Zhang
Xiangcheng Wang
Kang Ren
Zhonglue Chen
Xiaoguang Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590224

2,967 views
2 citations

Review

Published on 24 Jul 2025

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Keyi Zhang
Ming Wen
Xinyue Nan
Shuaizhu Zhao
Hao Li
Yanping Ai
Houze Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604378

6,007 views
4 citations

Original Research

Published on 24 Jul 2025

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

in Alzheimer's Disease and Related Dementias

Xiao Zhang
Sanoji Wijenayake
Shakhawat Hossain
Qian Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617611

2,846 views

Mini Review

Published on 24 Jul 2025

GLP-1R as a potential link between diabetes and Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Jingshan Shi
Yong Luo
Juan Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601602

4,152 views
1 citation

Review

Published on 23 Jul 2025

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

in Alzheimer's Disease and Related Dementias

Julia C. Colwell
Marina E. Emborg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598245

2,645 views
3 citations

Original Research

Published on 23 Jul 2025

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

in Cellular and Molecular Mechanisms of Brain-aging

Waqas Ahmad
Kyonghwan Choe
Riaz Ahmad
Tae Ju Park
Myeong Ok Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607289

5,228 views
4 citations

Original Research

Published on 23 Jul 2025

Vulnerability of long-range inputome of basal forebrain in normal aging mice

in Cellular and Molecular Mechanisms of Brain-aging

Tingting Sun
Jiale Chen
Bimin Liu
Anan Li
Hui Gong
Xiangning Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1573906

2,096 views

Original Research

Published on 23 Jul 2025

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

in Cellular and Molecular Mechanisms of Brain-aging

Laila S. Almassri
Kristen M. Crane
Sean R. Hergenrother
Gurveer Singh
Gillian L. Barach
Melina C. Iafrate
Joshua C. Harris
Nick Tokar
Andrew P. Ohl
Jesse W. Young

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1626021

2,151 views
2 citations

Original Research

Published on 23 Jul 2025

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Liangdong Zhou
Tracy A. Butler
Xiuyuan H. Wang
Samantha A. Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z. Lussier
Pedro Rosa-Neto
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

2,541 views

Original Research

Published on 23 Jul 2025

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

in Alzheimer's Disease and Related Dementias

Xuerui Pang
Yi Ji
Chenyang Hu
Yulong Dai
Panpan Hu
Xingqi Wu
Kai Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617191

2,622 views
2 citations

Review

Published on 23 Jul 2025

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

in Alzheimer's Disease and Related Dementias

Madison Cardillo
Keyura Katam
Prashanth Suravajhala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591796

6,417 views
8 citations

Original Research

Published on 23 Jul 2025

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications

in Neurocognitive Aging and Behavior

David Toloza-Ramirez
Rodrigo Santibañez
Leonardo Arraño-Carrasco
Romina Zunino-Pesce
Teresa Julio-Ramos
David A. Copland
Camilo Quezada
Carolina Mendez-Orellana

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547162

2,571 views

Original Research

Published on 22 Jul 2025

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso

in Neurocognitive Aging and Behavior

Shiang Hu
Xue Xiang
Xiaolong Huang
Yan Lu
Xulai Zhang
Dezhong Yao
Pedro A. Valdes-Sosa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1559067

3,186 views
2 citations

Original Research

Published on 22 Jul 2025

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

in Alzheimer's Disease and Related Dementias

Sang-Won Han
Young Ho Park
Jung-Min Pyun
Paula J. Bice
SangYun Kim
Andrew J. Saykin
Kwangsik Nho

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637368

2,633 views
1 citation

Mini Review

Published on 22 Jul 2025

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

in Cellular and Molecular Mechanisms of Brain-aging

Samantha G. Coleborn
Zoë M. Gilson
Yunyong Guo
Marie-Ève Tremblay

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1642043

2,986 views
2 citations

Original Research

Published on 22 Jul 2025

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

in Neurocognitive Aging and Behavior

Juanjuan Jiang
Tao Kang
Ronghua Ling
Yingqian Liu
Jiuai Sun
Yiming Li
Xiaoou Li
Hui Yang
Bingcang Huang
the Alzheimer’s Disease Neuroimaging Initiative

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1589018

2,543 views

Review

Published on 21 Jul 2025

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

in Alzheimer's Disease and Related Dementias

Bingyuan Zhou
Jing Li
Anqi Wu
Xuewei Wang
Le Cheng
Gaoshang Yang
Dahong Gao
Caifeng Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587986

4,307 views
5 citations

Original Research

Published on 21 Jul 2025

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

in Neurocognitive Aging and Behavior

Gen Miura
Tomoyo Morita
Jihoon Park
Eiichi Naito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1501011

2,347 views

Review

Published on 18 Jul 2025

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

in Parkinson’s Disease and Aging-related Movement Disorders

Ni Yang
Jing Liu
Dan Sun
Jiajun Ding
Lingzhi Sun
Xianghua Qi
Wei Yan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602426

5,589 views
1 citation

Original Research

Published on 17 Jul 2025

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

in Neurocognitive Aging and Behavior

Mark H. Sundman
Yilin Liu
Nan-kuei Chen
Ying-hui Chou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1597311

4,345 views
3 citations

Systematic Review

Published on 17 Jul 2025

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hui Wang
Chi Zhang
Dongxun Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612960

2,276 views

Original Research

Published on 16 Jul 2025

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

in Parkinson’s Disease and Aging-related Movement Disorders

Chang-hyun Park
Uicheul Yoon
Phil Hyu Lee
Jinna Kim
Seung-Koo Lee
Na-Young Shin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579326

2,060 views

Original Research

Published on 16 Jul 2025

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

in Neurocognitive Aging and Behavior

Yushu Huang
Xifan Yang
Qi Wang
Adila Abula
Yue Dong
Wenyuan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1532884

4,264 views
1 citation

Original Research

Published on 16 Jul 2025

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly

in Neurocognitive Aging and Behavior

Vivian Schultz
Benita Schmitz-Koep
Aurore Menegaux
Melissa Thalhammer
Severin Schramm
Su Hwan Kim
Claus Zimmer
Christian Sorg
Panteleimon Giannakopoulos
Marie-Louise Montandon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1542857

2,199 views

7,808 articles

articles

Modeling and validation of wearable sensor-based gait parameters in Parkinson’s disease patients with cognitive impairment

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

GLP-1R as a potential link between diabetes and Alzheimer’s disease

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Ambroxol confers neuroprotection against scopolamine-induced Alzheimer’s-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3β signaling pathways

Vulnerability of long-range inputome of basal forebrain in normal aging mice

Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease

Altered dynamic functional network connectivity patterns in Alzheimer’s disease: insights into neural dysfunction

Advancements in multi-omics research to address challenges in Alzheimer’s disease: a systems biology approach utilizing molecular biomarkers and innovative strategies

Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications

Lifespan brain age prediction based on multiple EEG oscillatory features and sparse group lasso

miR-423-5p and miR-92a-3p in Alzheimer’s disease: relationship with pathology and cognition

Sex differences in the outcomes of modifiable lifestyle factors for cognitive aging: neuroinflammation and microglia as key underlying mechanisms

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

Insights into targeted ferroptosis in mechanisms, biology, and role of Alzheimer's disease: an update

Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain

Motor symptoms of Parkinson’s disease: critical markers for early AI-assisted diagnosis

The glymphatic system as a therapeutic target: TMS-induced modulation in older adults

Orthostatic hypotension in Parkinson’s disease: effects on clinical features and disease severity-a systematic review and meta-analysis

Brain structural MRI marker for predicting conversion to Parkinson’s disease in individuals with prodromal symptoms

Development and validation of deep learning- and ensemble learning-based biological ages in the NHANES study

Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly