Frontiers in Bioengineering and Biotechnology

Mini Review

Accepted on 20 Jul 2026

Improved Healing and Tissue Regeneration for Prevention and Treatment of Pelvic Floor Disorders: From Reactive Treatment to Proactive Prevention

in Cell and Gene Therapy

Basak Akin
Sarah A Sinclair
Jan Paul Roovers
Zeliha Guler

Frontiers in Bioengineering and Biotechnology

Original Research

Published on 20 Jul 2026

Directed evolution of chlorotoxin enhances MMP-2 recognition and improves CAR-T-cell activity in glioblastoma models in vitro

in Cell and Gene Therapy

Anna Hajdara
Árpád Szöőr
József Murányi
Attila Brunyánszki
Gábor Z. Rácz
Daniel Cioca
Ambrus Gordos
Natali Bata
Noémi Nagy
Imre Fedorcsák

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1866928

543 views

Mini Review

Published on 15 Jul 2026

Macrophage-driven inflammation in inflammatory bowel disease: mechanisms and therapeutic opportunities

in Cell and Gene Therapy

Marta Rossi
Alessandra Spanò
Apolline Fortun
Nikita Camilleri
Marta Magatti
Andrea Papait
Antonietta Silini
Ornella Parolini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1856903

470 views

Perspective

Published on 08 Jul 2026

Engineering the future of advanced therapy medicinal products: a bioengineering call to action

in Cell and Gene Therapy

Giulia Nieri
Anna Spiller
Stella Federico
Alessandro Aiuti
Lorenzo Piemonti

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1868007

838 views

Mini Review

Published on 06 Jul 2026

What’s next for osteoarthritis gene therapy?

in Cell and Gene Therapy

Christopher H. Evans
Steven C. Ghivizzani
Annahita Keravala
Thomas W. Chalberg
Paul D. Robbins

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1871809

739 views

Editorial

Published on 06 Jul 2026

Editorial: Design strategies and equipment requirements for efficient process development and robust manufacturing of cell therapies

in Cell and Gene Therapy

Christoph Herwig
Volker Huppert
Ralf Pörtner

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1875958

946 views

Original Research

Published on 03 Jul 2026

AAV capsid sites breakdown: large protein insertions impact on vector dynamics

in Cell and Gene Therapy

Mariana V. Ferreira
Marina Curto
André Nascimento
Micael C. Freitas
Pedro M. F. Sousa
Filipe Freire
Tiago M. Bandeiras
Cristina Peixoto
Ana Sofia Coroadinha

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1862682

974 views

Original Research

Published on 03 Jul 2026

Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk

in Cell and Gene Therapy

Yuliya Nikitina
Alina Kazakova
Anastasia Leonteva
David Sergeevichev
Maria Bogachek
Sergey Vladimirov
Natalia Vasileva
Vladimir Richter
Anna Nushtaeva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1852454

1,722 views

Original Research

Accepted on 25 Jun 2026

Dendrobium officinale Nanovesicles: Transcriptomic Landscape and Anti-Inflammatory Roles

in Cell and Gene Therapy

Biren Wang
Yang Yang
Shuya Zhang
Jiazhen Wu
Yuyan Wei
Songzhu Xu
Yun Li
Qinhua Chen
Guangyi Yang

Frontiers in Bioengineering and Biotechnology

288 views

Original Research

Published on 19 Jun 2026

Collagen nanofiber reinforced alginate hydrogel tube microbioreactors for cell culture

in Cell and Gene Therapy

Xinran Wu
Yakun Yang
Ying Pan
Yong Wang
Xiaojun Lian
Cheng Dong
Shue Wang
Aijun Wang
Wuqiang Zhu
Wansheng Liu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1730541

986 views

Original Research

Published on 10 Jun 2026

Development of a gene-activated matrix for enhanced AAV gene delivery in vitro

in Cell and Gene Therapy

Ahmed Musoski
Florent Poulhès
Cedric Sapet
Neelam Iqbal
Payal Ganguly
Maximilian Kampick
Bastian Hoechst
Mario Marotta
Katja Dumler
Animesh Jha

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1832901

1,241 views

Review

Published on 08 Jun 2026

Characteristics of dermal fibroblasts and their biotherapeutic value in musculoskeletal system diseases

in Cell and Gene Therapy

Li Zhou
Qin Zhang
Hao Yang
Guicheng Zhang
Ming Fan
Rongguang Jin
Shen’ao Zhou

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1821137

1,219 views

Review

Published on 02 Jun 2026

A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999–2025)

in Cell and Gene Therapy

Varvara M. Derzhavina
Igor A. Khalymbadzha
Arseniy E. Yuzhalin

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1843047

1,515 views

Original Research

Published on 28 May 2026

Liposomes as delivery vectors for nucleic acid mimics into Escherichia coli: effect of composition and functionalization

in Cell and Gene Therapy

João P. Santos
Eva Pinho
Rita S. Santos
Joana A. Loureiro
Maria C. Pereira
Rui M. Ferreira
Céu Figueiredo
Emílio Gomes
Joana Castro
Daniela Araújo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1850483

1,334 views

Review

Published on 26 May 2026

Antibody display technologies from phages to cells: translational bottlenecks and AI-enabled opportunities

in Cell and Gene Therapy

Amrita Sahu
Punyatoya Das
Rohit Das
Indrajit Bhattacharya
Teeshyo Bhattacharya
Utpal Mohan
Remya Sreedhar
Somasundaram Arumugam

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1789373

1,983 views

Editorial

Published on 14 May 2026

Editorial: Advances in stem cell engineering: paving the way for regenerative medicine

in Cell and Gene Therapy

Katiucia Batista Silva Paiva
Shue Wang
Sukhbir Kaur

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1867976

1,384 views

Review

Published on 13 May 2026

Engineering the poly(A) tail for therapeutic mRNA: from expression control to manufacturing robustness

in Cell and Gene Therapy

Yang-Yang Zhang
Jian-Ping Zhang
Xiao-Bing Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1838589

2,885 views

Review

Published on 08 May 2026

Mammalian, plant, and gut microbiota-derived extracellular vesicles as emerging therapeutics for bone diseases

in Cell and Gene Therapy

Guanchen Yin
Hao Wang
Yi Liu
Zhenyan Wang
Xu Lin
Qisheng Cheng
Hang Gao

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1825617

1,488 views
1 citation

Review

Published on 24 Apr 2026

Genetic medicines for epilepsy: unlocking new avenues for seizure control

in Cell and Gene Therapy

Ing Chee Wee
Magdalena Przybyla
Jamelle Touma
Lars Matthias Ittner
Janet van Eersel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1768550

2,698 views

Review

Published on 23 Apr 2026

Inhalable extracellular vesicles as cell-free therapeutics for chronic respiratory disease

in Cell and Gene Therapy

Pinjie Zhang
Tingting Luo
Zhu Song
Hongxiang He
Yili Yang
Junfeng Jiang
Li Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1811444

2,676 views

Review

Published on 17 Apr 2026

Genetic manipulation technologies for precise cellular control: a comparative review of five approaches

in Cell and Gene Therapy

Qin Xiao
Panpan Sun
Jing Liu
Jia Li
Xueqin Xu
Ying Cao
Yanqiong Wu
Changbin Ke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1818170

1,875 views

Original Research

Published on 17 Apr 2026

Functional characterization of urine-derived stem cells from acute-on-chronic liver failure patients in an immune-mediated acute liver injury model

in Cell and Gene Therapy

Jiateng Zhang
Pengfei Yu
Jiaqi Li
Xiao Lin
Rui Zhao
Huaibin Zou
Yu Chen
Yuanyuan Zhang
Zhongping Duan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1759241

1,590 views

Opinion

Published on 15 Apr 2026

Revisiting MSC heterogeneity: significance of the CD73+CD39+CD146+ perivascular subset in bone marrow

in Cell and Gene Therapy

Ramya Lakshmi Rajendran
Atharva A. Mahajan
Byeong-Cheol Ahn
Prakash Gangadaran

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1810362

1,331 views

Original Research

Published on 14 Apr 2026

A fluffy nanofiber scaffold-based microenvironment enables a simplified, biology-centric scale-up strategy for mesenchymal stem/stromal cell culture

in Cell and Gene Therapy

Masashi Iwakami
Gabrielle Erwin Gemeniano Awitan
Riku Yamamoto
Masahiro Kino-oka

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2026.1808384

1,834 views

359 articles

articles

Improved Healing and Tissue Regeneration for Prevention and Treatment of Pelvic Floor Disorders: From Reactive Treatment to Proactive Prevention

Directed evolution of chlorotoxin enhances MMP-2 recognition and improves CAR-T-cell activity in glioblastoma models in vitro

Macrophage-driven inflammation in inflammatory bowel disease: mechanisms and therapeutic opportunities

Engineering the future of advanced therapy medicinal products: a bioengineering call to action

What’s next for osteoarthritis gene therapy?

Editorial: Design strategies and equipment requirements for efficient process development and robust manufacturing of cell therapies

AAV capsid sites breakdown: large protein insertions impact on vector dynamics

Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk

Dendrobium officinale Nanovesicles: Transcriptomic Landscape and Anti-Inflammatory Roles

Collagen nanofiber reinforced alginate hydrogel tube microbioreactors for cell culture

Development of a gene-activated matrix for enhanced AAV gene delivery in vitro

Characteristics of dermal fibroblasts and their biotherapeutic value in musculoskeletal system diseases

A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999–2025)

Liposomes as delivery vectors for nucleic acid mimics into Escherichia coli: effect of composition and functionalization

Antibody display technologies from phages to cells: translational bottlenecks and AI-enabled opportunities

Editorial: Advances in stem cell engineering: paving the way for regenerative medicine

Engineering the poly(A) tail for therapeutic mRNA: from expression control to manufacturing robustness

Mammalian, plant, and gut microbiota-derived extracellular vesicles as emerging therapeutics for bone diseases

Genetic medicines for epilepsy: unlocking new avenues for seizure control

Inhalable extracellular vesicles as cell-free therapeutics for chronic respiratory disease

Genetic manipulation technologies for precise cellular control: a comparative review of five approaches

Functional characterization of urine-derived stem cells from acute-on-chronic liver failure patients in an immune-mediated acute liver injury model

Revisiting MSC heterogeneity: significance of the CD73+CD39+CD146+ perivascular subset in bone marrow

A fluffy nanofiber scaffold-based microenvironment enables a simplified, biology-centric scale-up strategy for mesenchymal stem/stromal cell culture