Frontiers in Bioengineering and Biotechnology

Original Research

Published on 06 Jun 2025

An engineered adipose formulation decreases hepatic inflammation and fibrosis in a rodent model of metabolic dysfunction-associated steatotic liver disease

in Cell and Gene Therapy

Youngshim Choi
Yinyan Ma
Samson Tom
Alla Danilkovitch
Liqing Yu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1579062

220 views

Review

Accepted on 02 Jun 2025

Mesenchymal stem cells derived extracellular vesicles for chronic kidney disease: pleiotropic mechanisms of actions of a versatile therapy

in Cell and Gene Therapy

Ceccotti Elena
MARCO QUAGLIA
Giovanni Camussi
Stefania Bruno

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1612193

169 views

Review

Published on 30 May 2025

Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing

in Cell and Gene Therapy

Dong Han
Weiwei Liu
Jinpeng Gong
Yupeng Ma
Zhengwen Sun

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1568914

669 views

Perspective

Published on 29 May 2025

Challenges in lentiviral vector production: retro-transduction of producer cell lines

in Cell and Gene Therapy

Maximilian Klimpel
Christin Obert
Monica Terrao
Parameswari Singh
Haiyan Wei
Chao-Guang Chen
Andreas Gille
Silke Wissing
Holger Laux

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1569298

621 views

Review

Accepted on 27 May 2025

Chondroitinase ABC in Spinal Cord Injury: Advances in Delivery Strategies and Therapeutic Synergies

in Cell and Gene Therapy

Rachel Santana Cunha
Erik Aranha Rossi
Thaís Alves de Santana
Zaquer Suzana Munhoz Costa-Ferro
Bruno Solano De Freitas Souza

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1604502

378 views

Original Research

Published on 27 May 2025

Sustained capillary enlargement induced by angiogenic gene therapy does not support post-ischemic muscle recovery of hyperlipidemic mice

in Cell and Gene Therapy

Galina Wirth
Greta Juusola
Hanne Laakso
Nihay Laham-Karam
Seppo Ylä-Herttuala
Petra Korpisalo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1512962

609 views

Original Research

Accepted on 26 May 2025

Closed-system manufacturing of therapeutic NK cells using automated cell enrichment and concentration processes enables scalable, robust and costeffective solutions

in Cell and Gene Therapy

Nina Kok
Zoë Dekkers
Anica Loos
Thomas Bos
Puck van den Broek
Inge Post
Bertine Niessen
Jan Spanholtz
Volker Huppert
Monica Raimo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1586912

335 views

Review

Published on 20 May 2025

Bottom-up Biomaterial strategies for creating tailored stem cells in regenerative medicine

in Cell and Gene Therapy

Brenda Cruz-Gonzalez
Ellie Johandes
Dominique Gramm
Donny Hanjaya-Putra

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1581292

1,377 views

Review

Published on 14 May 2025

Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment

in Cell and Gene Therapy

Tiangang Chen
Dan Chen
Wanting Su
Jianlan Liang
Xiangning Liu
Mingxiang Cai

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1600227

1,067 views

Review

Published on 08 May 2025

Harnessing CRISPR potential for intervertebral disc regeneration strategies

in Cell and Gene Therapy

Catarina Milheiro
Maria L. Moura
Mario Amendola
Mário A. Barbosa
Joana Caldeira

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1562412

1,765 views

Correction

Published on 06 May 2025

Corrigendum: Screening for MicroRNA combination with engineered exosomes as a new tool against osteosarcoma in elderly patients

in Cell and Gene Therapy

Jiyu Han
Zitong Zhao
Yanhong Wang
Tao Yu
Daqian Wan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1615190

903 views

Original Research

Published on 06 May 2025

Involvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation

in Cell and Gene Therapy

Justin Caron
Marjan Ghanbariabdolmaleki
Madison Marino
Chong Qiu
Bo Wang
Michael Mak
Shue Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1570518

1,336 views

Review

Published on 24 Apr 2025

Mesenchymal stem cells and their extracellular vesicles: new therapies for cartilage repair

in Cell and Gene Therapy

Hongwei Yang
Haochen Yang
Qin Wang
Hanzhen Ji
Tianmei Qian
Yusen Qiao
Junfeng Shi
Meng Cong

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1591400

1,612 views

Original Research

Published on 04 Apr 2025

Autofluorescence lifetime imaging classifies human B and NK cell activation state

in Cell and Gene Therapy

Rebecca L. Schmitz
Jeremiah M. Riendeau
Kelsey E. Tweed
Peter Rehani
Kayvan Samimi
Dan L. Pham
Isabel Jones
Elizabeth M. Maly
Emmanuel Contreras Guzman
Matthew H. Forsberg

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1557021

1,419 views

Review

Published on 03 Apr 2025

Extracellular vesicles: innovative cell-free solutions for wound repair

in Cell and Gene Therapy

Hanne Eerdekens
Elke Pirlet
Sarah Willems
Annelies Bronckaers
Paula M. Pincela Lins

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1571461

1,526 views

Original Research

Published on 21 Mar 2025

Lymphoblastoid and Jurkat cell lines are useful surrogate in developing a CRISPR-Cas9 method to correct leukocyte adhesion deficiency genomic defect

in Cell and Gene Therapy

Ahmad R. Ramadan
Noureddine Ben Khalaf
Khaled Trabelsi
Halla Bakheit
Imen Ben-Mustapha
Mohamed-Ridha Barbouche
M-Dahmani Fathallah

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1548227

1,116 views