Frontiers in Bioengineering and Biotechnology

Original Research

Accepted on 14 May 2025

Sustained capillary enlargement induced by angiogenic gene therapy does not support post-ischemic muscle recovery of hyperlipidemic mice

in Cell and Gene Therapy

Galina Wirth
Greta Juusola
Hanne Laakso
Seppo Ylä-Herttuala
Petra Korpisalo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1512962

Review

Published on 14 May 2025

Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment

in Cell and Gene Therapy

Tiangang Chen
Dan Chen
Wanting Su
Jianlan Liang
Xiangning Liu
Mingxiang Cai

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1600227

323 views

Review

Accepted on 08 May 2025

Challenges and Future Perspectives in using Mesenchymal Stem Cells for Efficient Bone Fracture Healing

in Cell and Gene Therapy

Dong Han
Weiwei Liu
Jinpeng Gong
Yupeng Ma
Zhengwen Sun

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1568914

Review

Published on 08 May 2025

Harnessing CRISPR potential for intervertebral disc regeneration strategies

in Cell and Gene Therapy

Catarina Milheiro
Maria L. Moura
Mario Amendola
Mário A. Barbosa
Joana Caldeira

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1562412

837 views

Correction

Published on 06 May 2025

Corrigendum: Screening for MicroRNA combination with engineered exosomes as a new tool against osteosarcoma in elderly patients

in Cell and Gene Therapy

Jiyu Han
Zitong Zhao
Yanhong Wang
Tao Yu
Daqian Wan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1615190

420 views

Original Research

Published on 06 May 2025

Involvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation

in Cell and Gene Therapy

Justin Caron
Marjan Ghanbariabdolmaleki
Madison Marino
Chong Qiu
Bo Wang
Michael Mak
Shue Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1570518

670 views

Perspective

Accepted on 05 May 2025

Challenges in lentiviral vector production: retro-transduction of producer cell lines

in Cell and Gene Therapy

Maximilian Klimpel
Christin Obert
Monica Terrao
Parameswari Singh
Haiyan Wei
Chao-Guang Chen
Andreas Gille
Silke Wissing
Holger Laux

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1569298

Review

Published on 24 Apr 2025

Mesenchymal stem cells and their extracellular vesicles: new therapies for cartilage repair

in Cell and Gene Therapy

Hongwei Yang
Haochen Yang
Qin Wang
Hanzhen Ji
Tianmei Qian
Yusen Qiao
Junfeng Shi
Meng Cong

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1591400

1,139 views

Review

Accepted on 16 Apr 2025

Bottom-Up Biomaterial Strategies for Creating Tailored Stem Cells in Regenerative Medicine

in Cell and Gene Therapy

Donny Hanjaya-Putra
Brenda Cruz-Gonzalez
Ellie Johandes
Dominique Gramm

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1581292

354 views

Original Research

Published on 04 Apr 2025

Autofluorescence lifetime imaging classifies human B and NK cell activation state

in Cell and Gene Therapy

Rebecca L. Schmitz
Jeremiah M. Riendeau
Kelsey E. Tweed
Peter Rehani
Kayvan Samimi
Dan L. Pham
Isabel Jones
Elizabeth M. Maly
Emmanuel Contreras Guzman
Matthew H. Forsberg

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1557021

1,219 views

Review

Published on 03 Apr 2025

Extracellular vesicles: innovative cell-free solutions for wound repair

in Cell and Gene Therapy

Hanne Eerdekens
Elke Pirlet
Sarah Willems
Annelies Bronckaers
Paula M. Pincela Lins

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1571461

1,177 views

Original Research

Published on 21 Mar 2025

Lymphoblastoid and Jurkat cell lines are useful surrogate in developing a CRISPR-Cas9 method to correct leukocyte adhesion deficiency genomic defect

in Cell and Gene Therapy

Ahmad R. Ramadan
Noureddine Ben Khalaf
Khaled Trabelsi
Halla Bakheit
Imen Ben-Mustapha
Mohamed-Ridha Barbouche
M-Dahmani Fathallah

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1548227

917 views

Original Research

Published on 20 Mar 2025

Towards propagation of epidermal cells for wound repair: glass, as cell culture substrate, enhances proliferation and migration of human keratinocytes

in Cell and Gene Therapy

Hady Shahin
Ingrid Steinvall
Folke Sjöberg
Moustafa Elmasry
Ahmed El-Serafi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1547044

702 views

Opinion

Published on 19 Mar 2025

CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality

in Cell and Gene Therapy

Aleksander Szarzynski
Oliver Spadiut
Matthias Reisbeck
Gerhard Jobst
Rachel L. Paterson
Anna Kamenskaya
Emilie Gateau
Hanna P. Lesch
Luc Henry
Bence Kozma

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1563878

1,828 views

Original Research

Published on 05 Feb 2025

The landscape of cell regulatory and communication networks in the human dental follicle

in Cell and Gene Therapy

Jia-Ning Liu
Jiong-Yi Tian
Lu Liu
Yuan Cao
Xiao Lei
Xiao-Hui Zhang
Zi-Qi Zhang
Jun-Xi He
Chen-Xi Zheng
Chao Ma

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1535245

1,158 views

Review

Published on 29 Jan 2025

Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges

in Cell and Gene Therapy

Ling He
Qianrong Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1518398

1,720 views