Frontiers in Bioengineering and Biotechnology

Brief Research Report

Accepted on 18 Sep 2025

Advancing Cell Therapy Manufacturing: An Image-Based Solution for Accurate Confluency Estimation

in Cell and Gene Therapy

John Christopher Mason
Martin Kraft
Jakob Hueckels
Hao Wei
Konstantinos Spetsieris

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1651144

226 views

Review

Published on 09 Sep 2025

Biomimetic erythrocyte-based drug delivery systems for organ-targeted therapy

in Cell and Gene Therapy

Kehui Zhu
Yike Huang
Keying Li
Ke Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1663092

904 views

Original Research

Published on 05 Sep 2025

Enhancing lentiviral production for WAS gene therapy: a comparative analysis of stable producer cell lines evaluating flatware system and adherent bioreactors in perfusion mode

in Cell and Gene Therapy

Parameswari Singh
Nikki Indresh Lal
Monica Terrao
Sarah Schwingal
Martina Biserni
Florian Aeschimann
Andrea Strauch
Herbert Dersch
Angel Jaramillo
Andreas Gille

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1648028

1,865 views

Review

Published on 04 Sep 2025

Exosomes: the future of acellular nanotherapeutics in regenerative vascularization

in Cell and Gene Therapy

Jazzmyn S. Dawes
Maryam Abdelaal
Mary E. Landmesser
Mohammad Hossein Asgardoon
Olivia P. Waldron
Ji Ho Park
Neekita Jikaria
Dino J. Ravnic

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1607605

1,391 views

Original Research

Accepted on 02 Sep 2025

OSR1 and SIX2 Drive Divergent Transcrip7onal Programs in Human Kidney Cells: Implica7ons for Regenera7on and Tumorigenesis

in Cell and Gene Therapy

Naomi Pode-Shakked
Osnat Cohen-Zontag
Dorit Omer
Einav Vax
Orit Harari-Steinberg
Oren Pleniceanu
Benjamin Dekel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1645499

914 views

Mini Review

Accepted on 01 Sep 2025

The Potential of Microfluidic Cell Analysis in CAR T Cell Therapy Manufacturing

in Cell and Gene Therapy

Aleksandra Nikoniuk
Koki Lilova
Michael Thomas
Nicolas Szita

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1613836

620 views

Original Research

Accepted on 28 Aug 2025

A novel Frizzled 7 antibody that disrupts the Wnt pathway and inhibits Wilms tumor growth

in Cell and Gene Therapy

Einav Vax
Revital Caspi
Rachel Shukrun
Naomi Pode-Shakked
Oren Pleniceanu
Hana Golan
Michael Namestnikov
Michal Mark-Danieli
Ela Markovsky
Dekel D Bar-Lev

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1641137

494 views

Original Research

Published on 22 Aug 2025

Alternating 2D and 3D culture reduces cell size and extends the lifespan of placenta-derived mesenchymal stem cells

in Cell and Gene Therapy

Ying Pan
Li Han
Yakun Yang
Xinran Wu
Aijun Wang
Liangqi Xie
Wuqiang Zhu
Shue Wang
Yuguo Lei

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1632810

1,582 views

Systematic Review

Published on 13 Aug 2025

Meta-analysis of mesenchymal stem cell therapy for intrauterine adhesions: a comprehensive consideration of efficacy and safety

in Cell and Gene Therapy

Jiawei Gao
Xinyue Zhou
Nan Jiang
Yongjuan Zhang
Jianpeng Han
Tianyu Jia
Yanbiao Jiang
Xiaoling Ma
Haofei Shen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1619778

1,613 views

Original Research

Published on 06 Aug 2025

Macula densa cell angiogenic mechanisms and their therapeutic potential in kidney disease

in Cell and Gene Therapy

Georgina Gyarmati
Dorinne Desposito
Anne Riquier-Brison
Alejandra Becerra Calderon
Greta Trogen
Audrey Izuhara
Michifumi Yamashita
János Peti-Peterdi

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1606230

1,647 views

Original Research

Published on 05 Aug 2025

Poly-ether-ether-ketone wear particles induce a pro-inflammatory phenotype in a human monocytic cell line

in Cell and Gene Therapy

Shannon Jamieson
Philip Hyde
Patrick Card
David Deehan
John Kirby
Alison Tyson-Capper

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1507248

1,303 views

Original Research

Published on 25 Jul 2025

Regulation of RHBDD1 in the invasion of esophageal cancer cells via ELK3/Wnt/β-catenin signaling pathway

in Cell and Gene Therapy

Bing Xu
Hui Chen
Xinchen Sun
Hongyan Cheng
Kavimbi Chipusu
Wei Hua
Tingting Chen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1604859

1,467 views

Original Research

Published on 23 Jul 2025

Comprehensive analysis of pyroptosis-related genes in psoriasis and targeted gene editing of CASP1 and CASP5 using lipid nanoparticles to alleviate skin inflammation

in Cell and Gene Therapy

Gexiao Xu
Guanyi Ma
Jiachen Sun
Xiaoyan Yu
Jie Sun
Bing Gao

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1639869

2,264 views

Original Research

Published on 14 Jul 2025

A pilot study of healing critical-sized calvarial defects by LL-37-generated monoosteophils

in Cell and Gene Therapy

Keith Le
Huinan Liu
Chaoxing Zhang
Zhuo Li
Tove Olafsen
Yuman Fong
John E. Shively
Zhifang Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1583496

1,538 views

Original Research

Published on 04 Jul 2025

Cell retention in scalable, perfusion-based mesenchymal stem cell expansion processes: a proof of concept

in Cell and Gene Therapy

Samuel Lukas Schneider
Abiram Gopalakrishnan
Misha Alexander Teale
Regine Eibl

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1611703

1,765 views

Correction

Published on 26 Jun 2025

Correction: An engineered adipose formulation decreases hepatic inflammation and fibrosis in a rodent model of metabolic dysfunction-associated steatotic liver disease

in Cell and Gene Therapy

Youngshim Choi
Yinyan Ma
Samson Tom
Alla Danilkovitch
Liqing Yu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1642526

825 views